A placebo-controlled, double-blind prospective study in healthy female volunteers of dextrin sulphate gel: A novel potential intravaginal virucide

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 14, Issue 3, 1997, Pages 213-218

  Stafford, Michael K ^a   Cain, Dionne ^a   Rosenstein, Isobel ^a   Fontaine, Eli A ^a   McClure, Myra ^a   Flanagan, Adrienne M ^b   Smith, J Richard ^a   Taylor Robinson, David ^a   Weber, Jonathon ^a   Kitchen, Valerie S ^a,b  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Dextrin sulphate; Intravaginal virucide

Indexed keywords

ANTIVIRUS AGENT; DEXTRIN; DEXTRIN SULPHATE; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; COLPOSCOPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; ERYTHEMA; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INFLAMMATION; INTRAVAGINAL DRUG ADMINISTRATION; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PRURITUS; SEXUALLY TRANSMITTED DISEASE; VAGINA DISCHARGE; VAGINA FLORA; VIRUS TRANSMISSION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 12644279857     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199703010-00003     Document Type: Article

References (21)

1. Quinn TC. The epidemiology of the acquired immunodeficiency syndrome in the 1990s. Emerg Med Clin North Am 1995;13:1-25.
2. Stein ZA. Vaginal microbicides and prevention of HIV infection. Lancet 1994;343:362-3.
3. Worth D. Sexual decision-making and AIDS: why condom promotion among vulnerable women is likely to fail. Stud Fam Plann 1989;20:297-307.
4. Rosenberg JR, Gollub EL. Methods women can use that may prevent sexually transmitted disease, including HIV. Am J Public Health 1992;82:1473-8.
5. Popul Rep H 1990;8:1-36.
6. Elias JE. Heise LL. Challenges for the development of female-controlled vaginal microbicides. AIDS 1994;8:1-9.
7. Rosenberg MJ, Holmes KK. Virucides in prevention of HIV infection. Sex Transm Dis 1993;20:41-4.
8. Greenblatt RM, Lukehart SA, Plummer FA, et al. Genital ulceration as a risk factor for human immunodeficiency virus infection. AIDS 1988;2:47-50.
9. Plummer FA, Simonsen JN, Cameron DW, et al. Cofactors in male to female sexual transmission of human immunodeficiency virus type 1. J Infect Dis 1991;63:233-9.
10. Grosskurth H, Mosha F, Todd J, et al. Impact of improved treatment of sexually transmitted diseases on HIV infection in rural Tanzania: randomised controlled trial. Lancet 1995;346:530-6.
11. Ongradi J, Ceccherini-Nelli L, Pistello M, et al. Acid sensitivity of cell-free and cell-associated HIV-1: clinical implications. AIDS Res Hum Retroviruses 1990;6:1433-6.
12. Klebanoff SJ, Coombs RW. Virucidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission. J Exp Med 1991;174:289-92.
13. McClure MO, Whitby D, Patience C, et al. Dextrin sulphate and fucoidan are potent inhibitors of HIV infection in vitro. Antichem Chemo 1991;2:149-56.
14. McClure MO, Moore JP, Blanc DF, et al. Investigations into the mechanism by which sulphated polysaccharides inhibit HIV infection in vitro. AIDS Res Hum Retroviruses 1992;8:19-22.
15. Beddows S, Bieniasz P, Shaunak S, Weber J. HIV replication in CD4-negative cell lines: effect of cloning, CD4 expression and inhibition by dextrin sulphate. Antichem Chemo 1993;4:173-7.
16. Shaunak S, Gooderham NJ, Edwards RJ, et al. Infection by HIV-1 blocked by binding of dextrin 2-sulphate to the cell surface of activated human peripheral blood mononuclear cells and cultured T-cells. Br J Pharmacol 1994;113:151-8.
17. Golberg DP, Millier VF. A scaled version of the general health questionnaire. Psychol Med 1979;9:139-45.
18. Sjoberg I, Cajander S, Rylander E. Morphometric characteristics of the vaginal epithelium during the menstrual cycle. Gynecol Obstet Invest 1988;26:136-44.
19. Niruthisard S, Roddy RE, Chutivongse S. The effects of frequent Nonoxynol-9 use on the vaginal and cervical mucosa. Sex Trans Dis 1991;18:176-9.
20. Roddy RE, Cordera M, Cordero C, Fortney JA. A dosing study of Nonoxynol-9 and genital irritation. Int. J. STD AIDS 1993;4:165-70.
21. Meylan PRA, Kornbluth RS, Zbinden I, Richman DD. Influence of host cell type and V3 loop of the surface glycoprotein on susceptibility of human immunodeficiency virus type 1 to polyanion compounds. Antimicrob Agents Chemother 1994;38:2910-6.