Glycyrrhizin and some analogues induce growth of primary cultured adult rat hepatocytes via epidermal growth factor receptors

European Journal of Pharmacology

Volumn 431, Issue 2, 2001, Pages 151-161

  Kimura, Mitsutoshi ^a   Inoue, Hideo ^b   Hirabayashi, Kazuhiro ^b   Natsume, Hideshi ^a   Ogihara, Masahiko ^a  

^a JOSAI UNIVERSITY   (Japan)

^b Minophagen Pharmaceutical Co   (Japan)

Author keywords

Adult; DNA synthesis; Glycyrrhizin; Hepatocyte; Primary culture; Proliferation; Rat

Indexed keywords

18 ALPHA H GLYCYRRHETINIC ACID; 18 ALPHA H GLYCYRRHETINIC ACID 3 O BETA DEXTRO MONOGLUCURONIDE; 18 ALPHA H GLYCYRRHIZIN; 18 BETA H GLYCYRRHETINIC ACID; 18 BETA H GLYCYRRHETINIC ACID 3 O BETA DEXTRO MONOGLUCURONIDE; 18 BETA H GLYCYRRHIZIN; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; GENISTEIN; GLYCYRRHIZIC ACID; GLYCYRRHIZIC ACID DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; MONOCLONAL ANTIBODY; RAPAMYCIN; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG POTENCY; ENZYME INDUCTION; LIVER CELL CULTURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; ANTIBODIES, MONOCLONAL; CELL COUNT; CELL DIVISION; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCYRRHIZIC ACID; HEPATOCYTES; LIVER REGENERATION; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MOLECULAR STRUCTURE; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 0035900610     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01424-8     Document Type: Article

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