The pharmacokinetics of glycyrrhizin and its restorative effect on hepatic function in patients with chronic hepatitis and in chronically carbon-tetrachloride-intoxicated rats

Biopharmaceutics and Drug Disposition

Volumn 18, Issue 8, 1997, Pages 717-725

  Yamamura, Yoshikazu ^a,e   Kotaki, Hajime ^a   Tanaka, Naomi ^b   Aikawa, Tatsuya ^c   Sawada, Yasufumi ^d   Iga, Tatsuji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c Aikawa Internal Hospital   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO HOSPITAL   (Japan)

Author keywords

Carbon tetrachloride intoxicated rats; Chronic hepatitis; Glycyrrhizin; Hepatic function; Pharmacokinetics; Restorative effect

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; GLYCYRRHIZIC ACID;

ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; HUMAN; INTOXICATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIVER FUNCTION; LIVER TOXICITY; MALE; NONHUMAN; PHARMACOKINETICS; RAT;

ALANINE TRANSAMINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; ASPARTATE AMINOTRANSFERASES; CARBON TETRACHLORIDE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCYRRHIZIC ACID; HEPATITIS, CHRONIC; HUMANS; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; LIVER; MALE; RATS; RATS, WISTAR;

EID: 0030691962     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-081X(199711)18:8<717::AID-BDD54>3.0.CO;2-U     Document Type: Article

References (13)

1. S. Sotomatsu, Y. Takaishi, J. Hiroi, A. Namikata and N. Okano, Glycyrrhizin and skin. Skin Urol., 21, 138-144 (1959).
2. Y. Kiso, M. Tohkin, H. Hikino, M. Hattori, T. Sakamoto and T. Namba, Mechanism of antihepatic activity of glycyrrhizin, I. effect on free generation and lipid peroxidation. Planta Med., 50, 298-302 (1985).
3. N. Abe, T. Ebina and N. Ishida, Interferon induction by glycyrrizin and glycyrrhetinic acid in mice. Microbiol. Immunol., 26, 535-539 (1982).
4. H. Suzuki, Y. Ohta, T. Takino, K. Fujisawa, C. Hirayama, N. Shimizu and Y. Abe, Evaluation of effect of stronger neo-minophagen C in the treatment of chronic hepatitis study of double blind test. Igaku no Ayumi, 102, 562-578 (1977).
5. K. Fujisawa, Therapy of stronger neo-minophagen C. J. Ther., 69, 1633-1638 (1987).
6. H. Suzuki, Y. Ohta, T. Takino, K. Fujisawa and C. Hirayama, Effect of glycyrrhizin on biochemical tests in patients with chronic hepatitis double blind trial. Asian Med. J., 26, 423-438 (1983).
7. Y. Sakiya, T. Ichikawa, S. Ishida and Y. Samizo, Effect of glycyrrhizin on glutathione S-transferase activity and glutathione in rats intoxicated with carbon tetrachloride. Wakan-Yaku, 8, 167-172 (1991).
8. N. Tanaka, Y. Yamamura, T. Santa, H. Kotaki, K. Uchino, Y. Sawada, T. Aikawa, T. Osuga and T. Iga, Pharmacokinetic profiles of glycyrrhizin in patients with chronic hepatitis. Biopharm. Drug. Disposit., 14, 609-614 (1993).
9. Y. Yamamura, N. Tanaka, T. Santa, H. Kotaki, T. Aikawa, K. Uchino, T. Osuga, Y. Sawada and T. Iga, The relationship between pharmacokinetic behaviour of glycyrrizin and hepatic function in patients with acute hepatitis and liver cirrhosis. Biopharm. Drug Disposit., 16, 13-21 (1995).
10. T. Iga, Y. Sugiyama, M. Yokota, Y. Tomono, S. Awazu and M. Hanano, Pharmacokinetic aspects of sulfobromophthalcin transport in chronically carbon tetrachloride-intoxicated rats. Biochem. Pharmacol., 26, 1867-1875 (1977).
11. Y. Yamamura, J. Kawakami, T. Santa, H. Kotaki, K. Uchino, Y. Sawada, N. Tanaka and T. Iga, Pharmacokinetic profiles of healthy volunteers. J. Pharm. Sci., 81, 1042-1046 (1992).
12. K. Yamaoka, Y. Tanigawara, T. Nakagawa and T. Uno, A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobio-Dyn., 4, 879-885 (1981).
13. S. Ishida, Y. Sakiya, T. Ichikawa, Z. Taira and S. Awazu, Prediction of glycyrrhizin disposition in rats and man with liver failure by a physiologically based pharmacokinetic model. J. Pharmacobio-Dyn., 13, 142-157 (1990).