3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: Synthesis and biological activity of a novel group of potential antifungal drugs

Journal of Medicinal Chemistry

Volumn 44, Issue 17, 2001, Pages 2701-2706

  Pour, M ^a   Spulk M ^a   Buchta, V ^a   Kubanova P ^a   Voprsalova M ^a   Wsol V ^b   Fakova H ^a   Koudelka, P ^a   Pourova H ^a   Schiller, R ^a  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b Research Centre LN00B125   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

3 (3,4 DICHLOROPHENYL) 5 PIVALOYLOXYMETHYL 2H,5H FURAN 2 ONE; 3 PHENYL 5 ACYLOXYMETHYL 2H,5H FURAN 2 ONE DERIVATIVE; AMPHOTERICIN B; ANTIFUNGAL AGENT; FURAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; STRUCTURE ACTIVITY RELATION;

4-BUTYROLACTONE; AMPHOTERICIN B; ANTIFUNGAL AGENTS; FUNGI; FURANS; HUMANS; MICROBIAL SENSITIVITY TESTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035899172     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010155x     Document Type: Article

References (13)

1. Recent developments in pradimycin-benacomycin and triazole antibiotics
2. Recent advances in the medicinal chemistry of antifungal agents
3. Optically active antifungal azoles. VII. Synthesis and antifungal activity of stereoisomers of 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-l-methyl-3- (1H-1,2,4-triazol-1-yl)propyl]-4-[(2,2,3,3-tetrafluoropropoxy) phenyl]-3-(2H,4H)-1,2,4-triazolone (TAK 187)
4. Triazole antifungals. IV. Synthesis and antifungal activities of 3-acylamino-2-aryl-2-butanol derivatives
5. New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones
6. Voriconazole (UK-109496)
7. In vitro and in vivo activities of SCH-5692 (posaconazole), a new triazole antifungal agent, against Aspergillus and Candida
8. 3-Phenyl-5-methyl-2H,5H-furan-2-ones: Tuning antifungal activity by varying substituents on the phenyl ring
9. Incrustoporine, a new antibiotic from incrustoporia carneola (Bres.) Ryv. (Basidiomycetes)