Angiogenic gene therapy for heart disease: A review of animal studies and clinical trials

Cardiovascular Research

Volumn 49, Issue 3, 2001, Pages 561-567

  Hammond, H Kirk ^a   McKirnan, M Dan ^b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b Collateral Therapeutics ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 4; PLASMID DNA; PLASMID VECTOR; SCATTER FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN 121; VASCULOTROPIN 165; VIRUS VECTOR;

ADENOVIRUS; ANGIOGENESIS; CLINICAL TRIAL; DISEASE MODEL; DOG; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; GENE THERAPY; GENE TRANSFER; HEART MUSCLE ISCHEMIA; HEART MUSCLE REVASCULARIZATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SWINE; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALS; COLLATERAL CIRCULATION; CONTROLLED CLINICAL TRIALS; CORONARY CIRCULATION; CORONARY VESSELS; DISEASE MODELS, ANIMAL; DNA; ENDOTHELIAL GROWTH FACTORS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEART VENTRICLES; HUMANS; INJECTIONS; INJECTIONS, INTRA-ARTERIAL; LYMPHOKINES; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PHYSIOLOGIC; PERICARDIUM; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035895738     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(00)00257-1     Document Type: Review

References (19)

1. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart
2. Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart
3. Direct in vivo gene transfer into porcine myocardium using replication-deficient adenoviral vectors
4. Safety of direct myocardial administration of an adenovirus vector encoding vascular endothelial growth factor 121
5. Adenovirus-mediated acidic fibroblast growth factor gene transfer induces angiogenesis in the nonischemic rabbit heart
6. Electromagnetic guidance for catheter-based transendocardial injection: A platform for intramyocardial angiogenesis therapy
7. Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant coronary artery disease
8. Intramyocardial gene therapy with naked DNA encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium
9. Evaluation of the effects of intramyocardial injection of DNA expressing vascular endothelial growth factor (VEGF) in a myocardial infarction model in the rat - Angiogenesis and angioma formation
10. VEGF gene delivery to myocardium: Deleterious effects of unregulated expression
11. Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: Up-regulation of essential transcription factor for angiogenesis, ets
12. Complete reversal of ischemic wall motion abnormalities by combined use of gene therapy with transmyocardial laser revascularization
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14. Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease
15. 165 via a minithoracotomy
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17. Regional deficits of myocardial blood flow and function in left ventricular pacing-induced heart failure
18. Intracoronary gene transfer of fibroblast growth factor-4 increases regional contractile function and responsiveness to adrenergic stimulation in heart failure
19. Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury