Impact of the basic amine on the biological activity and intracellular distribution of an aza-anthrapyrazole: BBR 3422

Biochemical Pharmacology

Volumn 62, Issue 10, 2001, Pages 1337-1343

  Chou, Kai Ming ^a   Paul Krapcho, A ^a   Hacker, Miles P ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Aza anthrapyrazole; DNA intercalation; Intracellular distribution; Multidrug resistance; P glycoprotein; Photoaffinity labeling

Indexed keywords

2 (2 AMINOETHYL) 5 (2 METHYLAMINOETHYL)INDAZOLO[4,3 G,H]ISOQUINOLIN 6(2H) ONE; ANTINEOPLASTIC AGENT; AZIDOPINE; BBR 3422; DOXORUBICIN; GLYCOPROTEIN P; HETEROCYCLIC COMPOUND; PYRAZOLE DERIVATIVE; SALICYLIC ACID DERIVATIVE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL;

ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DRUG CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; INTERCALATION COMPLEX; MULTIDRUG RESISTANCE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; AZIDES; BINDING, COMPETITIVE; CELL DIVISION; DIHYDROPYRIDINES; DNA; DRUG INTERACTIONS; DRUG RESISTANCE, MULTIPLE; ELECTROPHORESIS, AGAR GEL; HUMANS; INDAZOLES; ISOQUINOLINES; P-GLYCOPROTEIN; PHOTOAFFINITY LABELS; SUBCELLULAR FRACTIONS; TRITIUM; TUMOR CELLS, CULTURED;

EID: 0035892357     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00797-3     Document Type: Article

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