In situ expression of interleukin-4 (IL-4) receptors in human brain tumors and cytotoxicity of a recombinant IL-4 cytotoxin in primary glioblastoma cell cultures

Cancer Research

Volumn 61, Issue 22, 2001, Pages 8058-8061

  Joshi, Bharat H ^a   Leland, Pamela ^a   Asher, Anthony ^c   Prayson, Richard A ^d   Varricchio, Frederick ^b   Puri, Raj K ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^c Carolina Neurosurgery and Spine   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN; INTERLEUKIN 4 RECEPTOR; RECOMBINANT INTERLEUKIN 4;

ARTICLE; BRAIN TUMOR; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; DRUG MECHANISM; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RECEPTOR BINDING;

BRAIN NEOPLASMS; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOTOXINS; INTERLEUKIN-4; RECEPTORS, INTERLEUKIN-4; RECOMBINANT PROTEINS;

EID: 0035890415     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Human neurological cancer cells express interleukin-4 (IL-4) receptors which are targets for the toxic effects of IL4-Pseudomonas exotoxin chimeric protein
2. Receptors for interleukin (IL)-4 do not associate with the common γ chain, and IL-4 induces the phosphorylation of JAK2 tyrosine kinase in human colon carcinoma cells
3. Structure of and signal transduction through interleukin-4 and interleukin-13 receptors
4. Development of a recombinant interleukin-4-Pseudomonas exotoxin for therapy of glioblastoma
5. Interleukin-13 receptor α′ but not α chain: A functional component of interleukin-4 receptors
6. Interleukin-13 receptor α chain: A novel tumor-associated transmembrane protein in primary explants of human malignant gliomas
7. A circularly permutated recombinant interleukin 4 toxin with increased activity
8. An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of γ c chain in RCC cells does not improve sensitivity
9. Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma
10. Complete regression of established human glioblastoma tumor xenograft by interleukin-4 toxin therapy
11. Interleukin-4 receptordirected cytotoxin therapy of AIDS-associated Kaposi's sarcoma tumors in xenograft model
12. Human breast carcinoma cells express type II IL-4 receptors and are sensitive to antitumor activity of a chimeric IL-4-Pseudomonas exotoxin fusion protein in vitro and in vivo
13. Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma
14. In vivo expression of the interleukin 4 receptor α by astrocytes in epilepsy cerebral cortex
15. T cell adoptive immunotherapy of newly diagnosed gliomas
16. Immunostaining of interleukin-4 receptor on human renal cell carcinoma
17. Interleukin-4 receptor expression on AIDS-associated Kaposi's sarcoma cells and their targeting by a chimeric protein comprised of circularly permutated interleukin-4 and Pseudomonas exotoxin
18. Expression of high-affinity interleukin 4 receptors on murine sarcoma cells and receptor-mediated cytotoxicity of tumor cells to chimeric protein between interleukin 4 and Pseudomonas exotoxin
19. Interleukin-4 receptor expression on human lung tumors and normal lung
20. Structure, function, and targeting of interleukin 4 receptors on human head and neck cancer cells