ShcA tyrosine phosphorylation sites can replace ShcA binding in signalling by middle T-antigen

EMBO Journal

Volumn 20, Issue 22, 2001, Pages 6337-6346

  Nicholson, Philippa R ^a   Empereur, Sylvie ^a   Glover, Hilary R ^a   Dilworth, Stephen M ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Polyoma virus MT; ShcA phosphorylation; Signal transduction; Transformation

Indexed keywords

BINDING PROTEIN; GENE PRODUCT; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN GAB1; PROTEIN SHCA; PROTEIN SOS1; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; VIRUS MIDDLE T ANTIGEN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CELL TRANSFORMATION; CONTROLLED STUDY; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL MEMBRANE; FIBROBLASTS; GRB2 ADAPTOR PROTEIN; MICE; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEINS; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; SOS1 PROTEIN; SRC HOMOLOGY DOMAINS; TYROSINE;

ANIMALIA; DNA VIRUSES; MURINAE; POLYOMAVIRUS;

EID: 0035890153     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.22.6337     Document Type: Article

References (48)

1. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the ras signaling pathway
2. Gab-coupling to the HGF/Met receptor multifunctional docking site requires binding of Grb2 and correlates with the transforming potential
3. Hierarchy of binding sites for Grb2 and Shc on the epidermal growth-factor receptor
4. A region in Shc distinct from the SH2 domain can bind tyrosinephosphorylated growth factor receptors
5. The role of the Shc phosphotyrosine interaction/ phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen -mediated cell transformation
6. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen
7. Emerging roles for SH2/PTB-containing Shc adaptor proteins in the developing mammalian brain
8. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation
9. Requirement of SHP2 binding to Grb2-associated binder-1 for mitogen-activated protein kinase activation in response to lysophosphatidic acid and epidermal growth factor
10. Polyoma virus middle T antigen: Meddler or mimic?
11. Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc
12. Polyomavirus middle T-antigen NPTY mutants
13. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins
14. A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3
15. Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/ mitogen-activated protein kinase activation
16. A general method of in vitro preparation and specific mutagenesis of DNA fragments: Study of protein and DNA interactions
17. A Grb2-associated docking protein in EGF- and insulin-receptor signalling
18. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor
19. Polyomavirus-derived middle-T antigen as a probe for T-cell antigen receptor-coupled signaling pathways
20. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
21. A Drosophila shc gene product is implicated in signaling by the DER receptor tyrosine kinase
22. Erythropoietin induces the tyrosine phosphorylation of GAB1 and its association with SHC, SHP2, SHIP and phosphatidylinositol 3-kinase
23. Transformation-defective mutants of polyömavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells
24. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases
25. Signal transduction. How receptors turn Ras on
26. Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism
27. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
28. Polyoma virus middle T-antigen: Growth factor receptor mimic
29. Interaction of Shc with adaptor protein adaptins
30. The ShcA and Grb2 adapter proteins mediate endothelial cell transformation and Gab1 tyrosine phosphorylation induced by polyomavirus middle T-antigen
31. Protein modules and signalling networks
32. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
33. Biochemical and genetic analysis of the Drk SH2/ SH3 adaptor protein of Drosophila
34. T antigens role in polyomavirus transformation: c-myc but not c-fos or c-jun expression is a target for middle T
35. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS
36. Determination of Gab1 (Grb2-associated binder-1) interaction with insulin receptor-signaling molecules
37. Phosphatidylinositol-3-OH kinase as a direct target of Ras
38. Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins
39. Coupling of Gab1 to c-Met, Grb2 and Shp2 mediates biological responses
40. How receptor tyrosine kinases activate Ras
41. Polyomavirus middlesized tumor antigen modulates c-jun phosphorylation and transcriptional activity
42. Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase
43. Activation and nuclear translocation of mitogen-activated protein kinases by polyomavirus middle-T or serum depend on phosphatidylinositol 3-kinase
44. The PTB domain: A new protein module implicated in signal transduction
45. A conserved aminoterminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides
46. The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein-protein interactions
47. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth