Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis

Free Radical Biology and Medicine

Volumn 31, Issue 10, 2001, Pages 1254-1262

  Hazell, Linda J ^a   Baernthaler, Georg ^a   Stocker, Roland ^a  

^a HEART RESEARCH INSTITUTE   (Australia)

Author keywords

Apolipoprotein B 100; Atherogenesis; Free radicals; Hypochlorite; LDL; Myeloperoxidase

Indexed keywords

APOLIPOPROTEIN B100; HYPOCHLORITE; LOW DENSITY LIPOPROTEIN; MYELOPEROXIDASE;

ADULT; ADVENTITIA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BLOOD VESSEL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; ILIAC ARTERY; IMMUNOHISTOCHEMISTRY; INTIMA; MALE; OXIDATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN MODIFICATION; TUNICA MEDIA;

ADULT; APOLIPOPROTEIN B-100; APOLIPOPROTEINS B; ARTERIOSCLEROSIS; DISEASE PROGRESSION; FEMALE; HUMANS; HYPOCHLOROUS ACID; ILIAC ARTERY; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; OXIDATION-REDUCTION; PEROXIDASE; TUNICA INTIMA; TUNICA MEDIA;

EID: 0035890124     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00717-1     Document Type: Article

References (51)

1. Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity
2. Antioxidants and atherosclerotic heart disease
3. Extensive nitration of protein tyrosine in human atherosclerosis detected by immunohistochemistry
4. Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima
5. Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions
6. Involvement of 15-lipoxygenase in early stages of atherogenesis
7. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice
8. Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque
9. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions
10. 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima
11. p-Hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modifies phospholipid amino groups of low density lipoprotein in human atherosclerotic intima
12. Presence of hypochlorite-modified proteins in human atherosclerotic lesions
13. Oxidation of low-density lipoprotein with hypochlorite causes transformation of the lipoprotein into a high-uptake form for macrophages
14. Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidation
15. Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro
16. Hypochlorite-modified low density lipoprotein inhibits nitric oxide synthesis in endothelial cells via an intracellular dislocalization of endothelial nitric-oxide synthase
17. Enhancement of immunogenic properties of ovalbumin as a result of its chlorination
18. Chemotactic factor inactivation by the myeloperoxidease-hydrogen peroxide-halide system
19. Activation of the fifth component of human complement by oxygen-derived free radicals, and by methionine oxidizing agents: A comparison
20. Immune mechanisms in atherosclerosis
21. Immunohistochemical localization of the terminal C5b-9 complement complex in human aortic fibrous plaque
22. Potential roles of hypochlorous acid and N-chloroamines in collagen breakdown by phagocytic cells in synovitis
23. Oxidative damage to fibronectin. I. The effects of the neutrophil myeloperoxidase system and HOCl
24. Activation of latent human neutrophil collagenase by reactive oxygen species and serine proteases
25. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques
26. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases
27. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes
28. The oxidative inactivation of tissue inhibitor of metalloproteinase-1 (TIMP-1) by hypochlorous acid (HOCl) is suppressed by anti-rheumatic drugs
29. Mechanism of hypochlorite-mediated inactivation of proteinase inhibition by α2-macroglobulin
30. Macrophages, macrophage foam cells, and eccentric intimal thickening in the coronary arteries of young children
31. Immunologic detection and measurement of hypochlorite-modified LDL with specific monoclonal antibodies
32. A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
33. Oxidation and antioxidation of human low-density lipoprotein and plasma exposed to 3-morpholinosydnonimine and reagent peroxynitrite
34. 2/halide system in human atherosclerotic lesions: Colocalization of myeloperoxidase and hypochlorite-modified proteins
35. Apo B concentration in the normal human aorta
36. Atherosclerosis and degenerative diseases of blood vessels
37. Inside the neutrophil phagosome: Oxidants, myeloperoxidase, and bacterial killing
38. Quantification of alterations in structure and function of elastin in the arterial media
39. Arterial elastin as seen with scanning electron microscopy: A review
40. Human atherosclerosis. III. Immunocytochemical analysis of the cell composition of lesions of young adults
41. Inflammatory infiltrates in human coronary atherosclerosis
42. Mass spectrometric quantification of amino acid oxidation products in proteins: Insights into pathways that promote LDL oxidation in the human artery wall
43. Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino- acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions
44. Increased atherosclerosis in myeloperoxidase-deficient mice
45. The molecular action of α-tocopherol in lipoprotein lipid peroxidation: Pro- and antioxidant activity of vitamin E in complex heterogeneous lipid emulsions
46. Tocopherol-mediated peroxidation (TMP) of lipoproteins: Implications for vitamin E as a potential antiatherogenic supplement
47. α-Tocopherol does not inhibit hypochlorite-induced oxidation of apolipoprotein B-100 of low-density lipoprotein
48. Vitamin E supplementation and cardiovascular events in high-risk patients
49. Dietary and pharmacological antioxidants in atherosclerosis
50. A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the committee on vascular lesions of the council on arteriosclerosis, American Heart Association