Sorting of internalized neurotrophins into an endocytic transcytosis pathway via the Golgi system: Ultrastructural analysis in retinal ganglion cells

Journal of Neuroscience

Volumn 21, Issue 22, 2001, Pages 8915-8930

  Butowt, Rafal ^a   Von Bartheld, Christopher S ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Anterograde transport; BDNF; Degradation; Golgi; Internalization; K252a; Lysosome; Neurotrophic factor; NGF; NT 3; p75 neurotrophin receptor; Retina; Sorting; trkB; trkC; Visual system

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; PROTEIN TYROSINE KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CELL MEMBRANE; CELL SELECTION; CELL ULTRASTRUCTURE; CHICKEN; CONTROLLED STUDY; EMBRYO; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVITY; GOLGI COMPLEX; INTERNALIZATION; LYSOSOME; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; RETINA GANGLION CELL; TRANSCYTOSIS;

EID: 0035890076     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-22-08915.2001     Document Type: Article

References (107)

1. Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and Schwann cells in vitro
2. The nerve growth factor receptor: A multicomponent system that mediates the actions of the neurotrophin family of proteins
3. 125I-beta NGF
4. Electron microscopic radioautographic localization of iodinated nerve growth factor bound to and internalized by PC12 cells
5. 125I] nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors
6. Characterization of nerve growth factor (NGF) release from hippocampal neurons: Evidence for a constitutive and an unconventional sodium-dependent regulated pathway
7. TGN38 is maintained in the trans-Golgi network by a tyrosine-containing motif in the cytoplasmic domain
8. Functional interactions of neurotrophins and neurotrophin receptors
9. Sorting of internalized neurotrophins by trk kinase activity: Ultrastructural analysis in retinal ganglion cells
10. Purification of chick retinal ganglion cells for molecular analysis: Combining retrograde labeling and immunopanning yields 100% purity
11. Brainderived neurotrophic factor is an anterograde survival factor in the rat visual system
12. High resolution autoradiography. I. Methods
13. Retrieval of TGN proteins from the cell surface requires endosomal acidification
14. The time of origin and the pattern of survival of neurons in the isthmo-optic nucleus of the chick
15. 125I-nerve growth factor in cultured rat sympathetic neurons
16. Anterograde transport of neurotrophin proteins in the CNS: A reassessment of the neurotrophic hypothesis
17. Differential role of the low-affinity neurotrophin receptor (p75) in retrograde axonal transport of the neurotrophins
18. Immunohistochemical analysis of the neurotrophins BDNF and NT-3 and their receptors trkB, trkC, and p75 in the developing chick retina
19. The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons
20. Activity- and Ca(2+)-dependent modulation of surface expression of brain-derived neurotrophic factor receptors in hippocampal neurons
21. Regional specialization of the chick retina as revealed by the size and density of neurons in the ganglion cell layer
22. Characterization of neurotrophin receptors by affinity cross-linking
23. Internalization and cycling of nerve growth factor in PC12 cells: Interconversion of type II (fast) and type I (slow) nerve growth factor receptors
24. Nerve growth factor nonresponsive pheochromocytoma cells: Altered internalization results in signaling dysfunction
25. Neurotrophin-3 sorts to the constitutive secretory pathway of hippocampal neurons and is diverted to the regulated secretory pathway by coexpression with brain-derived neurotrophic factor
26. Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: Direct NT-3 activation of TrkB neurons in vivo
27. Detection of brain-derived neurotrophic factor in a vesicular fraction of brain synaptosomes
28. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
29. Basic fibroblast growth factor: Receptor-mediated internalization, metabolism, and anterograde transport in retinal ganglion cells
30. Partial characterization of chicken Thy-1 glycoprotein by monoclonal antibodies
31. Localized sources of neurotrophins initiate axon collateral sprouting
32. Modulation of nerve growth factor internalization by direct interaction between p75 and TrkA receptors
33. Expression of trkB receptor isoforms in the developing avian visual system
34. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons
35. Low density lipoprotein receptor and cation-independent mannose 6-phosphate receptor are transported from the cell surface to the Golgi apparatus at equal rates in PC12 cells
36. Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity
37. Endocytosis of activated TrkA: Evidence that nerve growth factor induces formation of signaling endosomes
38. Expression of neurotrophins and trk receptors in the avian retina
39. A series of normal stages in the development of the chick embryo
40. Evidence that all newly synthesized proteins destined for axonal transport pass through the Golgi apparatus
41. Dendroaxonal transcytosis of transferrin in cultured hippocampal and sympathetic neurons
42. Contributions of the optic tectum and the retina as sources of brain-derived neurotrophic factor for retinal ganglion cells in the chick embryo
43. Structure and developmental expression of the chicken NGF receptor
44. The regulated secretion and vectorial targeting of neurotrophins in neuroendocrine and epithelial cells
45. Endocytosis of nerve growth factor by PC12 cells studied by quantitative ultrastructural autoradiography
46. Selective inhibition of transcytosis by brefeldin A in MDCK cells
47. Recycling of a secretory granule membrane protein after stimulated secretion
48. Lamina-specific connectivity in the brain: Regulation by N-cadherin, neurotrophins, and glycoconjugates
49. 125I] NGF
50. Endocytosis of cholera toxin into neuronal GERL
51. Nerve growth factor (NGF) receptor on rat glial cell lines. Evidence for NGF internalization via p75NGFR
52. p75 nerve growth factor receptor modulates p140trkA kinase activity, but not ligand internalization, in PC12 cells
53. Neurotrophin signal transduction in the nervous system
54. Nerve growth factor receptor TrkA is expressed by horizontal and amacrine cells during chicken retinal development
55. K-252 compounds: Modulators of neurotrophin signal transduction
56. Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo
57. Binding and degradation of nerve growth factor by PC12 pheochromocytoma cells
58. Inhibition of the NT-3 receptor TrkC, early in chick embryogenesis, results in severe reductions in multiple neuronal subpopulations in the dorsal root ganglia
59. Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic
60. Chimeric forms of furin and TGN38 are transported with the plasma membrane in the trans-Golgi network via distinct endosomal pathways
61. A tryptic digestion fragment of nerve growth factor with nerve growth promoting activity
62. Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons
63. Nerve growth factor treatment increases brainderived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord
64. Differential sorting of nerve growth factor and brain-derived neurotrophic factor in hippocampal neurons
65. Endocytosis
66. BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: Partial disagreement with mRNA levels
67. The endosomal-lysosomal system of neurons: New roles
68. Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain
69. Endocytic routes to the Golgi apparatus
70. Displaced ganglion-cells in the chick retina
71. Development of the retinotectal projection in the chicken
72. Intracellular receptor binding and nuclear transport of nerve growth factor in intact cells and a cell-free system
73. An NGF-TrkAmediated retrograde signal to transcription factor CREB in sympathetic neurons
74. Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor
75. Internalization of nerve growth factor by pheochromocytoma PC12 cells: Absence of transfer to the nucleus
76. Mouse astrocytes store and deliver brain-derived neurotrophic factor using the non-catalytic gp95trkB receptor
77. Resolution of electron microscope autoradiography. IV. Application to analysis of autoradiographs
78. Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin
79. Axonal and transneuronal transport in the transmission of neurological disease: Potential role in system degenerations, including Alzheimer's disease
80. A TrkAselective, fast internalizing nerve growth factor-antibody complex induces trophic but not neuritogenic signals
81. Selective trans-synaptic migration of tetanus toxin after retrograde axonal transport in peripheral sympathetic nerves: A comparison with nerve growth factor
82. Intracellular signaling pathways activated by neurotrophic factors
83. Effect of brefeldin A and lysosomotropic reagents on intracellular trafficking of epidermal growth factor and transferrin in Madin-Darby canine kidney epithelial cells
84. Uptake and transepithelial transport of nerve growth factor in suckling rat ileum
85. Cell death and the transport of neurotrophins in the rat visual system
86. TrkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
87. Endocytosis of nerve growth factor by "differentiated" PC12 cells studied by quantitative ultrastructural autoradiography
88. Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor
89. 125I-nerve growth factor in rat sympathetic neurons in compartmented cultures
90. Assaying binding of nerve growth factor to cell surface receptors
91. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1benzopyran-4-one (LY294002)
92. Identification of the receptors which bind the neurotrophins BDNF and NT-3 during retrograde and anterograde axonal transport
93. Neurotrophins in the developing and regenerating visual system. Invited review
94. Radio-iodination of neurotrophins and their delivery in vivo: Advantages of membrane filtration and the use of disposable syringes
95. Tracing with radiolabeled neurotrophins
96. Expression of neurotrophin-3 (NT-3) and anterograde axonal transport of endogenous NT-3 by retinal ganglion cells in chick embryos
97. Target-derived BDNF (brainderived neurotrophic factor) is essential for the survival of developing neurons in the isthmo-optic nucleus
98. Expression of nerve growth factor (NGF) receptors in the brain and retina of chick emi bryos: Comparison with cholinergic development
99. Anterograde transport and axo-dendritic transfer of neurotrophins in the developing visual system
100. NTR and trkB receptors
101. Anterograde transport, transcytosis, and recycling of neurotrophic factors: The concept of trophic currencies in neural networks. Invited review
102. Effects of NT-3 on the number, size and vesicle density of retinotectal synapses in chick embryos
103. Mechanisms of the release of anterogradely transported neurotrophin 3 from presynaptic axon terminals
104. Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors
105. Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the receptor TrkB
106. Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rapl
107. Cell surface Trk receptors mediate NGF-induced survival while internalized receptors regulate NGF-induced differentiation