Dysregulated expression of pre-Tα reveals the opposite effects of pre-TCR at successive stages of T cell development

Journal of Immunology

Volumn 167, Issue 10, 2001, Pages 5689-5696

  Lacorazza, H D ^a   Porritt, H E ^a   Nikolich Zugich J ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0035889891     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.10.5689     Document Type: Article

References (34)

1. Tissue interactions in the development of the thymus lymphocytes
2. Early T lymphocytes: Differentiation in vivo of adult intrathymic precursor cells
3. Developmental status and reconstitution potential of subpopulations of murine thymocytes
4. Phenotypic and functional stages in thymocyte development
5. Control points in early T-cell development
6. Analysis and expression of a cloned pre-T cell receptor gene
7. Pleiotropic changes controlled by the pre-T-cell receptor
8. Pre-TCR signaling components trigger transcriptional activation of a rearranged TCRα gene locus and silencing of the pre-TCRα locus: Implications for intrathymic differentiation
9. Competitive displacement of pT-α by T cell receptor (TCR)-α during TCR assembly dictates the sequential surface expression of pre-TCR and αβ TCR during thymocyte development
10. Positive selection of thymocytes
11. Mutation in T-cell antigen receptor genes α and β block thymocyte development at different stages
12. Crucial role of the pre-T-cell receptor α gene in development of α-β but not γ-δ T cells
13. The α-β versus γ-δ T-cell lineage choice
14. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells
15. Precursor thymocyte proliferation and differentiation are controlled by signals unrelated to the pre-TCR
16. NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development
17. Functional dissection of lck proximal promoter
18. + cells following intrathymic injection
19. Normal sequence of phenotypic transitions in one cohort of 5-bromo-2′-deoxyuridine-pulse-labeled thymocytes
20. Accumulation of bromodeoxyuridine-labeled cells in central and peripheral lymphoid organs: Minimal estimates of production and turnover rates of mature lymphocytes
21. Turnover of naive- and memory-phenotype T cells
22. Early T cell receptor β gene expression is regulated by the pre-T cell receptor-CD3 complex
23. Productive T-cell receptor β-chain gene rearrangement: Coincident regulation of cell cycle and clonality during development in vivo
24. +) thymocytes in normal and genetically modified mice
25. -/- mice
26. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bel-2
27. Premature expression of T cell receptor (TCR) αβ suppresses TCR γδ gene rearrangement but permits development of γδ lineage T cells
28. Premature TCRαβ expression and signaling in early thymocytes impair thymocyte expansion and partially block their development
29. -/- mice by anti-CD3e antibody treatment or with transgenes encoding activated Lck or tailless pTα
30. Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains
31. Different initiation of pre-TCR and γδ TCR signalling
32. 2+ mobilization and activation of NF-κB and NFAT
33. lck with the pre-T cell receptor during thymocyte development