Progesterone regulated expression of flavin-containing monooxygenase 5 by the B-isoform of progesterone receptors: Implications for tamoxifen carcinogenicity

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 9, 1997, Pages 2956-2961

  Miller, Marilyn M ^a,b,d   James, R Andrew ^a,c   Richer, Jennifer K ^a   Gordon, David F ^a   Wood, William M ^a   Horwitz, Kathryn B ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROGESTERONE; PROGESTERONE RECEPTOR; PROMEGESTONE; TAMOXIFEN; UNSPECIFIC MONOOXYGENASE;

ARTICLE; CANCER CELL CULTURE; DRUG CARCINOGENICITY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

EID: 0030929265     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.82.9.4239     Document Type: Article

References (34)

1. Lydon JF, DeMayo FJ, Funk CR, et al. 1995 Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 9:2266-2278.
2. Clarke I, Sutherland, R. 1990 Progestin regulation of cellular proliferation. Endocr Rev. 11:266-287.
3. Horwitz KB. 1992 The molecular biology of RU486. Is there a role for anti-progestins in the treatment of breast cancer? Endocr Rev. 13:146-163.
4. Hagley RD, Moore MR. 1985 A progestin effect on lactate dehydrogenase in the human breast cancer cell line T-47D. Biochem Biophys Res Commun. 128:520-524.
5. Di Lorenzo D, Albertini A, Zava D. 1991 Progestin regulation of alkaline phosphatase in the human breast cancer cell line T47 D. Cancer Res. 51:4470-4475.
6. Chambon M, Rochefort H, Vial HH, Chalbos D. 1989 Progestins and androgens stimulate lipid accumulation in T47D breast cancer cells via their own receptors. J Steroid Biochem. 33:915-922.
7. Horwitz KB, Alexander PS. 1983 In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation. Endocrinology. 113:2195-2201.
8. Tora L, Gronemeyer H, Turcotte B, Gaub MP, Chambon P. 1988 The N-terminal of the chicken progesterone receptor specifies target gene activation. Nature. 333:185-188.
9. Mohammed MK, Tung L, Takimoto GS, Horwitz KB. 1994 The leucine zippers of c-fos and c-jun for progesterone receptor dimerization: A-dominance in the A/B heterodimer. J Steroid Biochem Mol Biol. 51:241-250.
10. Tung L, Mohamed KM, Hoeffler JP, Takimoto GS, Horwitz KB. 1993 Antagonist-pccupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol. 7:1256-1265.
11. Vegeto E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP. 1993 Human progesterone A form is a cell and promoter specific repressor of human progesterone B function. Mol Endocrinol. 7:1244-1255.
12. Graham JD, Yeates C, Balleine RL, et al. 1995 Characterization of progesterone receptor A and B expression in human breast cancer. Cancer Res. 55:5063-5068.
13. Wiehle RD, Mangal R, Poindexter AN, Weigel NL. 1995 Human progesterone receptor A and B expression during the menstrual cycle. Proceedings of the 77th Annual Meeting of The Endocrine Society, Washington, DC, 1995, p 224 (Abstract).
14. Sartorius CA, Groshong SD, Miller LA, et al. 1994 New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cyclic AMP. Cancer Res. 54:3868-3877.
15. Liang P, Pardee AB. 1992 Differential display of eukaryotic messenger RNA by means of polymerase chain reaction. Science. 257:967-970.
16. Mani C, Kupfer D. 1991 Cytochrome P-450-mediated activation and irreversible binding of the anti-estrogen tamoxifen to proteins in rat and human liver: possible involvement ot flavin-containing monooxygenases in tamoxifen activation. Cancer Res. 51:6052-6058.
17. Overby LH, Buckpitt AR, Lawton MP, Atta-Asafo-Adjei E, Schulze J, Philpot RM. 1995 Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. Arch Biochem Biophys. 317:275-284.
18. Hemminki K, Rajaniemi H, Lindahl B, Moberger B. 1996 Tamoxifen induced DNA adducts in endometrial samples from breast cancer patients. Cancer Res. 56:4374-4377.
19. Wei LL, Krett NL, Francis MD, et al. 1988 Multiple human progesterone receptor messenger ribonucleic acids and their autoregulation by progestin agonists and antagonists in breast cancer cells. Mol Endocrinol. 2:62-72.
20. Southern EM. 1975 Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol. 98:503-517.
21. Smith CL, Conneely OM, O'Malley BW. 1993 Modulation of the ligand independent activation of the human estrogen receptor by hormone and antihormone. Proc Natl Acad Sci USA. 90:6120-6124.
22. Horwitz KB, McGuire WL, Pearson OH, Segaloff A. 1975 Predicting response to endocrine therapy in human breast cancer: a hypothesis. Science. 189:726-727.
23. Pierkarz RL, Cohen D, Horwitz SB. 1993 Progesterone regulates murine multidrug resistance mdr1b gene. J Biol Chem. 268:7613-7616.
24. Sager R, Anisowicz A, Neveu M, Liang P, Sotripoulus G. 1993 Identification by differential display of alpha 6 integrin as a candidate tumor suppressor gene. FASEB J. 7:964-970.
25. Williams DE, Hale SE, Muerhoff AS, Masters BSS. 1985 Rabbit lung flavin-containing monooxygenases: purification, characterization, and induction during pregnancy. Mol Pharm. 28:381-390.
26. Osmitz TG, Kulkarni AP. 1982 Oxidative metabolism of xenobiotics during pregnancy: significance of microsomal flavin-containing monooxygenase. Biochem Biophys Res Commun. 109:1164-1171.
27. Lee MY, Clark JE, Williams DE. 1993 Induction of flavin-containing monooxygenase (FMOB) in rabbit lung and kidney by sex steroids and glucocorticoids. Arch Biochem Biophys. 302:332-336.
28. Lee M-L, Smiley S, Kadkhodayan S, Hines RN, Williams DE. 1995 Developmental regulation of flavin-containing monooxygenase (FMO) isoforms 1 and 2 in pregnant rabbit. Chem Biol Interact. 96:75-95.
29. Ziegler DM, Poulsen LL. 1977 Protein disulfide bond synthesis: a possible intracellular mechanism. Trends Biochem Sci. 2:79-81.
30. Sausen PJ, Elfarra AA. 1990 Cystein conjugated S-oxidase. J Biol Chem. 265:6139-6145.
31. Nelson SE, Kamataki T, Waxman DJ, et al. 1993 The P450 superfamily: update on new consequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol. 12:1-51.
32. Jordan VC. 1988 The development of tamoxifen for breast cancer therapy: a tribute to the late Arthur Walpole. Breast Cancer Res Treat. 11:197-209.
33. Rutqvist LE, Johansson H, Signomklao T, Johansson U, Fornander T, Wilking N. 1995 Adjuvant tamoxifen therapy for early stage breast cancer and second primary malignancies. J Natl Cancer Inst. 87:645-651.
34. Curtis RE, Bioce, Jr, JD, Shriner DA, Hankey BF, Fraumeni, Jr, F. 1996 Second cancers after adjuvant tamoxifen therapy for breast cancer. J Natl Cancer Inst 88:832-834.