Tissue dynamics of CD8 lymphocytes that suppress viral replication in cats infected neonatally with feline immunodeficiency virus

Journal of Infectious Diseases

Volumn 184, Issue 6, 2001, Pages 671-681

  Crawford, P Cynthia ^a   Papadi, George P ^a   Levy, Julie K ^b   Benson, Neal A ^a   Mergia, Ayalew ^a   Johnson, Calvin M ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b University of Florida College of Veterinary Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CAT; CONTROLLED STUDY; FELINE IMMUNODEFICIENCY VIRUS; LYMPH NODE; LYMPHOCYTE COUNT; LYMPHOCYTE CULTURE; LYMPHOCYTOSIS; LYMPHOID TISSUE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; THYMUS; TISSUE DISTRIBUTION; VIRUS INHIBITION; VIRUS LOAD; VIRUS REPLICATION;

ANIMALS; ANIMALS, NEWBORN; CATS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FELINE ACQUIRED IMMUNODEFICIENCY SYNDROME; FLOW CYTOMETRY; IMMUNODEFICIENCY VIRUS, FELINE; LYMPH NODES; REGRESSION ANALYSIS; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TIME FACTORS; VIREMIA; VIRUS REPLICATION;

EID: 0035884267     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/323076     Document Type: Article

References (82)

1. HIV-1 and the thymus
2. HIV-1: The infective process in vivo
3. Human immunodeficiency virus infection of human thymus and disruption of the thymic microenvironment in the SCID-hu mouse
4. Thymocyte and thymic microenvironment alterations during a systemic HIV infection in a severe combined immunodeficient mouse model
5. +) cell depletion in human immunodeficiency virus type 1-infected SCID-hu mice suggest direct viral killing of thymocytes in vivo
6. Human immunodeficiency virus type 1 pathogenesis in SCID-hu mice correlates with syncytium-inducing phenotype and viral replication
7. The human thymus: A chimeric organ comprised of central and peripheral lymphoid components
8. CD8 cell noncytotoxic antiviral activity in human immunodeficiency virus-infected and -uninfected children
9. - T-cell-mediated suppression of HIV replication in the first year of life: Association with lower viral load and favorable early survival
10. Deficient human immunodeficiency virus type 1-specific cytotoxic T cell responses in vertically infected children
11. Detection of HIV-specific cell-mediated cytotoxicity in the peripheral blood from infected children
12. + T cells in peripheral blood leukocytes of asymptomatic HIV carriers in vitro
13. + T cell suppressor activities: Dichotomy between infected and uninfected individuals, evolution with progression of disease, and sensitivity to gamma irradiation
14. + T cells correlates with CD4 counts and clinical stage of disease
15. Virological and immunological features of long-term human immunodeficiency virus-infected individuals who have remained asymptomatic compared with those who have progressed to acquired immunodeficiency syndrome
16. +) T-cell decrease
17. - T cells: Implications for the development of therapeutic strategies
18. +) cell noncytotoxic anti-HIV response
19. CD8 T-cell-mediated inhibition of HIV replication in HIV infected adults and children
20. Selective thymocyte depletion and immunoglobulin coating in the thymus of cats infected with feline immunodeficiency virus
21. Primary stage of FIV infection: Viral dissemination and cellular targets
22. Immunopathologic changes in the thymus during the acute stage of experimentally induced feline immunodeficiency virus infection in juvenile cats
23. + antiviral activity in cats infected with feline immunodeficiency virus
24. + antiviral response that correlates with reduction of cell-associated virus
25. + cell phenotype mediating antiviral activity in feline immunodeficiency virus-infected cats is characterized by reduced surface expression of the CD8β chain
26. +) T lymphocytes suppresses FIV replication
27. + T lymphocytes
28. Progressive expansion of an L-selectin-negative CD8 cell with anti-feline immunodeficiency virus (FIV) suppressor function in the circulation of FIV-infected cats
29. - T cell non-cytolytic anti-feline immunodeficiency virus activity mediated by a soluble factor(s)
30. - thymic lymphocytes express reduced levels of CD8-beta and increased interferon-γ in cats perinatally infected with the JSY3 molecular clone of feline immunodeficiency virus
31. 1 JSY3 induces immunodeficiency in specific-pathogen-free cats
32. In vivo lymphocyte tropism of feline immunodeficiency virus
33. Interleukin-2 suppression in cats naturally infected with feline leukemia virus
34. Characterization of monoclonal antibodies to feline T lymphocytes and their use in the analysis of lymphocyte tissue distribution in the cat
35. Characterization of anti-feline CD8 monoclonal antibodies
36. Biphasic thymus response by kittens inoculated with feline immunodeficiency virus during fetal development
37. + lymphocyte depletion following feline immunodeficiency virus infection
38. + cell anti-HIV activity; nonlytic suppression of virus replication
39. - cells in cats infected with feline immunodeficiency virus
40. T cells overexpressing interferon-γ and interleukin-10 are found in both the thymus and secondary lymphoid tissues of feline immunodeficiency virus-infected cats
41. Phenotypic and functional characterization of lymphocytes derived from normal and HIV-1-infected human lymph nodes
42. T-cell homeostasis in HIV-1 infection
43. + T cell subsets during acute Epstein-Barr and human immunodeficiency virus infections in humans
44. Viro-immunological studies in acute HIV-1 infection
45. Characteristics of the CD8+ lymphocytosis during primary simian immunodeficiency virus infections
46. + T cells with a predominant V beta usage during the primary immune response to HIV
47. Primary HIV infection: Host responses and intervention strategies
48. +CD28-cell population in the blood and lung of HIV-positive patients
49. + T cells: Evidence for a soluble inhibitor
50. + T cells and this effect overrides its ability to stimulate virus expression
51. A semiquantitative assay for CD8- T-cell-mediated suppression of human immunodeficiency virus type 1 infection
52. + cells from asymptomatic human immunodeficiency virus-infected individuals suppress superinfection of their peripheral blood mononuclear cells
53. + cell antiviral factor
54. + anti-human immunodeficiency virus suppressor activity (CASA) in response to antiretroviral therapy: Loss of CASA is associated with loss of viremia
55. + lymphocytes from HIV-2-infected baboons
56. + cells from HIV-2-infected baboons control HIV replication
57. + lymphocyte appears in lymph nodes of rhesus monkeys early after infection with simian immunodeficiency virus
58. + ratio in cats experimentally infected with feline immunodeficiency virus
59. + lymphocyte subset
60. - pre-T cell subset
61. Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain
62. + T cells in the thymus
63. +) pre-T cells during human intrathymic development
64. + T cells with thymic peptides
65. The importance of lymphocyte trafficking in regulating blood lymphocyte levels during HIV and SIV infections
66. The effect of cytokines and chemotactic agonists on the migration of T lymphocytes into skin
67. ICAM-1-independent lymphocyte transmigration across high endothelium: Differential up-regulation by interferon-γ, tumor necrosis factor-α and interleukin i-β
68. Interferon induces peripheral lymphadenopathy in mice
69. Lymphocyte homing and homeostasis
70. Orchestrated information transfer underlying leukocyte endothelial interactions
71. IFN-γ influences the migration of thoracic duct B and T lymphocyte subsets in vivo: Random increase in disappearance from the blood and differential decrease in reappearance in the lymph
72. Immunological and virological changes associated with decline in CD4/CD8 ratios in lymphoid organs of SIV-infected macaques
73. Virus-induced cytokines regulate circulating lymphocyte levels during primary SIV infections
74. Cytokine response in multiple lymphoid tissues during the primary phase of feline immunodeficiency virus infection
75. Exclusion of circulating T cells from the thymus does not apply in the neonatal period
76. Expression of different CD8 isoforms on distinct human lymphocyte subpopulations
77. + lymphoid dendritic cells
78. Novel CD8 molecule on macrophages and mast cells: Expression, function and signaling
79. +NKT cells
80. An early expansion of CD8αβ T cells, but depletion of resident CD8αα cells, occurs in the intestinal epithelium during primary simian immunodeficiency virus infection
81. Decreased CD8 cell-mediated viral suppression and other immunologic characteristics of women who transmit human immunodeficiency virus to their infants