Idiotypic protein-pulsed adherent peripheral blood mononuclear cell- derived dendritic cells prime immune system in multiple myeloma

Clinical Cancer Research

Volumn 4, Issue 4, 1998, Pages 957-962

  Wen, Yue Jin ^a   Ling, Min ^a   Bailey Wood, Roy ^a   Lim, Seah H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; B7 ANTIGEN; BETA 2 MICROGLOBULIN; CD1 ANTIGEN; CD14 ANTIGEN; CD3 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN P 15095; HLA DR ANTIGEN; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN IDIOTYPE; IMMUNOGLOBULIN M ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN; MELPHALAN; PARAPROTEIN; PROTEIN; RECOMBINANT INTERLEUKIN 2;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; DENDRITIC CELL; DOSE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IMMUNOPHENOTYPING; MALE; MONONUCLEAR CELL; MULTIPLE MYELOMA; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINATION;

ADULT; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, NEOPLASM; ANTINEOPLASTIC AGENTS, ALKYLATING; DENDRITIC CELLS; HUMANS; IMMUNOTHERAPY; LEUKOCYTES, MONONUCLEAR; MALE; MELPHALAN; MULTIPLE MYELOMA; VACCINATION;

EID: 0031917994     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Mellstedt, H., Holm, G., and Bjorkholm, M. Multiple myeloma, Waldenstrom's macroglobulinaemia and benign monoclonal gammopathy. Characteristics of the B-cell clone, immunoregulatory cell populations and clinical implications. Adv. Cancer Res., 41: 257-289, 1984.
2. Bergui, L., Schena, M., Gaidano, G., Riva, M., and Galigaris-Cappio, E. Interleukin-3 and interleukin-6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma. J. Exp. Med., 170: 613-618, 1989.
3. Larsen, C. P., Ritchie, S. C., Hendrix, R., Linsley, P. S., Hathcock, K. S., Hodes, R. J., Lowry, R. P., and Pearson, T. C. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J. Immunol., 152: 5208-5219, 1994.
4. Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P., and Hodes, R. J. Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function. J. Exp. Med., 180: 631-640, 1994.
5. Flamand, V., Sornasse, T., Thielemans, K., Demanet, G., Bakkus, M., Bazin, H., Tielemans, F., Leo, O., Urbain, J., and Muser, M. Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo. Eur. J. Immunol., 24: 605-610, 1994.
6. Hsu, F. J., Benike, C., Fagnoni, F., Liles, T. M., Czerwinski, D., Taidi, B., Engelman, E. G., and Levy, R. Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells. Nat. Med., 2: 52-58, 1996.
7. Caux, C., Dezutter-Dambuyant, C., Schmitt, D., and Banchereau, J. GM-CSF and TNF-a cooperate in the generation of dendritic Langerhans cells. Nature (Lond.), 360: 258-260, 1992.
8. Egner, W., and Hart, D. N. J. The phenotype of freshly isolated and cultured human bone marrow allostimulatory cells: possible heterogeneity in bone marrow dendritic cell populations. Immunology, 85: 611-620, 1995.
9. Reid, C. D. L., Stackpoole, A., Meager, A., and Tikerpae, J. Interactions of tumor necrosis factor with granulocyte-macrophage colonystimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J. Immunol., 149: 2681-2688, 1992.
10. Sallusto, F., and Lanzavecchia, A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α. J. Exp. Med., 179: 1109-1118, 1994.
11. Romani, N., Gruner, S., Brang, D., Kampgen, E., Lenz, A., Trockenbacher, B., Konwalinka, G., Fritsch, P. O., Steinman, R. M., and Schuler, G. Proliferating dendritic cell progenitors in human blood. J. Exp. Med., 180: 83-93, 1994.
12. Campbell, M. J., Esserman, L., Byars, N. E., Allison, A. C., and Levy, R. Idiotype vaccination against murine B cell lymphoma. Humoral and cellular requirements for the full expression of antitumor immunity. J. Immunol., 145: 1029-1036, 1990.
13. Tao, M. H., and Levy, R. Idiotype/granulocyte-macrophage colonystimulating factor fusion protein as a vaccine for B-cell lymphoma. Nature (Lond.), 362: 755-758, 1993.
14. Chen, T. T., Tao, M. H., and Levy, R. Idiotype-cytokine fusion proteins as a cancer vaccines. Relative efficacy of IL-2, IL-4, and granulocyte-macrophage colony-stimulating factor. J. Immunol., 153: 4775-4787, 1994.
15. George, A. J., Folkard, S. G., Hamblin, T. J., and Stevenson, F. K. Idiotypic vaccination as a treatment for a B-cell lymphoma. J. Immunol., 141: 2168-2174, 1988.
16. Campbell, M. J., Esserman, L., and Levy, R. Immunotherapy of established murine B-cell lymphoma: combination of idiotype immunisation and cyclophosphamide. J. Immunol., 141: 3227-3233, 1988.
17. Kwak, L. W., Campbell, M. J., Czerwinski, D. K., Hart, S., Miller, R. A., and Levy, R. Induction of immune responses in patients with B-cell lymphoma against the surface-immunoglobulin idiotype expressed by their tumors. N. Engl. J. Med., 327: 1209-1215, 1992.
18. Wen, Y. J., and Lim, S. H. T cells recognize the VH complementarity-determining region 3 of the idiotypic protein of B-cell non-Hodgkin's lymphoma. Eur. J. Immunol., 27: 1043-1047, 1997.
19. Osterborg, A., Yi, Q., Bergenbrant, S., Holm, G., Lefvert, A., and Mellstedt, H. Idiotypic-specific T cells in multiple myeloma stage I: an evaluation by four different functional tests. Br. J. Haematol., 89: 110-116, 1995.
20. Kwak, L. W., Taub, D. D., Duffey, P. L., Bensinger, W. I., Bryant, E. M., Reynolds, C. W., and Longo, D. L. Transfer of myeloma idiotypic-specific immunity from an actively immunised marrow donor. Lancet, 345: 1016-1020, 1995.
21. Wen, Y. J., Ling, M., and Lim, S. H. Immunogenicity and crossreactivity with idiotypic IgA of VH CDR3 peptide in multiple myeloma. Br. J. Haematol., in press, 1998.
22. Kwak, L. W., Young, H. A., Pennington, R. W., and Weeks, S. D. Vaccination with syngeneic lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice to a protective T-cell response. Proc. Natl. Acad. Sci. USA, 93: 10972-10978, 1996.