Asymmetry: Molecular, biologic, embryopathic, and clinical perspectives

American Journal of Medical Genetics

Volumn 101, Issue 4, 2001, Pages 292-314

  Cohen Jr , M Michael ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Asymmetric cell division; Asymmetric embryopathies; Asymmetric signaling molecules; Asymmetric vascular syndromes; Behavioral asymmetry; Chiral molecules; Hemiatrophy; Hemihyperplasia; Hemihypoplasia; Laterality; Lefty1; Lefty2; Nodal; Node monocilia; Pitx2; Plagiocephaly; Situs ambiguus; Situs inversus; Somatic mosaicism

Indexed keywords

ACTIVIN RECEPTOR; ACTIVIN RECEPTOR IIA; FIBROBLAST GROWTH FACTOR 8; GENE PRODUCT; HOMEODOMAIN PROTEIN; MYELOPID; NERVE CELL ADHESION MOLECULE; PROTEIN CSNR; PROTEIN LEFTY 1; PROTEIN LEFTY 2; PROTEIN NODAL; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR PITX2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ACCESSORY SPLEEN; ALBRIGHT SYNDROME; ANGIOOSTEOHYPERTROPHY SYNDROME; ASPLENIA; BEHAVIOR TERATOLOGY; CELL DIVISION; CHIRALITY; CLEFT FACE; CONFERENCE PAPER; CRANIOFACIAL MALFORMATION; EMBRYOPATHY; FIBROUS DYSPLASIA; GENE MUTATION; HEMISPHERIC DOMINANCE; HETEROTAXY SYNDROME; HUMAN; MOSAICISM; MULTIPLE CANCER; NONHUMAN; PLAGIOCEPHALY; PRIORITY JOURNAL; SITUS INVERSUS; STURGE WEBER SYNDROME; SYNOSTOSIS; TERATOLOGY;

ABNORMALITIES; ANIMALS; BODY PATTERNING; CELL DIVISION; EYE ABNORMALITIES; GENE EXPRESSION REGULATION; HUMANS;

ANIMALIA;

EID: 0035879420     PISSN: 01487299     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajmg.1217     Document Type: Conference Paper

References (119)

1. Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer
2. The spleen
3. The right and the sinister
4. Cell proliferation in mammalian gastrulation: The ventral node and notochord are relatively quiescent
5. Proteus syndrome: Diagnostic criteria, differential diagnosis, and patient evaluation
6. Regulation of midline development by antagonism of lefty and nodal signaling
7. An accessory mouth
8. The development of handedness in left/right asymmetry
9. Frontal plagiocephaly: Synostotic, compensational, or deformational
10. Mechanisms of left-right determination in vertebrates
11. Two rights make a wrong: Human left-right malformations
12. Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis
13. Human dysmorphic syndromes with craniofacial abnormalities
14. The nose
15. Perspectives on craniofacial asymmetry. I. The biology of aymmetry
16. Perspectives on craniofacial asymmetry. II. Asymmetric embryopathies
17. Perspectives on craniofacial asymmetry. III. Common and/or well-known causes of asymmetry
18. Perspectives on craniofacial asymmetry. IV. Hemiasymmetries
19. Perspectives on craniofacial asymmetry. V. The craniosynostoses
20. Perspectives on craniofacial asymmetry. VI. The hamartoses
21. A comprehensive and critical assessment of overgrowth and overgrowth syndromes
22. Fibrous dysplasia is a neoplasm
23. Klippel-Trenaunay syndrome
24. Proteus syndrome: Clinical evidence for somatic mosaicism and selective review
25. Some neoplasms and some hamartomatous syndromes: Genetic considerations
26. Understanding Proteus syndrome, unmasking the Elephant Man, and stemming elephant fever
27. A newly recognized hamartomatous syndrome
28. Etiology of fibrous dysplasia and McCune-Albright syndrome
29. Cranial size and configuration in the Apert syndrome
30. Suture formation, premature sutural fusion, and suture default zones in Apert syndrome
31. Oculoauriculovertebral spectrum: An updated critique
32. Two-hit model for sporadic congenital anomalies in mice with the disorganization mutation
33. Disorganization is a completely dominant gain-of-function mouse mutation causing sporadic developmental defects
34. Premature closure of the frontozygomatic suture: Unusual frontoorbital dysplasia mimicking unilateral coronal synostosis
35. Heterotaxy with left atrial isomerism in a patient with deletion 18p
36. Disorganization: A model for "early amnion rupture"?
37. Developmental anomalies suggestive of the human homologue of the mouse mutant disorganization
38. New associations of primary ciliary dyskinesia syndrome
39. Asymmetric development of mitochondrial activity in rat embryos as a determinant of the defect patterns induced by exposure to hypoxia, hyperoxia, and redox cyders in vitro
40. Frontal plagiocephaly secondary to synostosis of the frontosphenoidal suture
41. Nitrous oxide alters body laterality in rats
42. Right-left asymmetries in the brain
43. Interhemispheric asymmetries of the modular structure in human temporal cortex
44. N-cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry
45. Increased crown-size asymmetry in trisomy G
46. The meaning of bilateral asymmetry in the permanent dentition
47. X-linked situs abnormalities result from mutations in ZIC3
48. Cerebral lateralization
49. Human brain: Left-right asymmetries in temporal speech region
50. Congenital hemihypertrophy
51. Normal asymmetry and unilateral hypertrophy
52. Frontal plagiocephaly. Diagnosis and treatment
53. The McCune-Albright syndrome: A lethal gene surviving by mosaicism
54. Lethal genes surviving by mosaicism: A possible explanation for sporadic birth defects involving the skin
55. Links in the left/right axial pathway
56. Another human homologue for the mouse mutant disorganization
57. Isolated hemihyperplasia (hemihypertrophy): Report of a prospective multicenter study of the incidence of neoplasia and review
58. The differential diagnosis of posterior plagiocephaly: True lambdoid synostosis versus positional molding
59. The inheritance and expression of disorganization, an unusual mutation in the mouse
60. Developmental anomalies in mice resulting from the action of the gene, disorganization, a semi-dominant lethal
61. The left-right coordinator: The role of Vg1 in organizing left-right axis formation
62. Control of vertebrate left-right asymmetry by a snail related zinc finger gene
63. Asymmetric cell division
64. Asymmetric adaptive modeling of central tarsal bones in racing greyhounds
65. Patterns of pyramidal decussation and their relationship to handedness
66. Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development
67. Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB
68. Role of inscuteable in orienting asymmetric cell divisions in Drosophila
69. Craniofacial characteristics of Proteus syndrome: Two modes of abnormal growth
70. The calvaria and cranial base in Apert and Crouzon syndromes - A three-dimensional CT analysis
71. Peripheral and cerebral asymmetries in the rat
72. Human brain: Morphologic differences in the hemispheres demonstrable by carotid arteriography
73. A molecular pathway determining left-right asymmetry in chick embryogenesis
74. Progressive hemifacial atrophy (Parry-Romberg syndrome report with review of genetics and nosology
75. Heterotaxy: Associated conditions and hospital-based prevalence in newborns
76. Plagiocephaly: Differential diagnosis based on endocranial morphology
77. Osseous anatomy of unilateral coronal synostosis
78. Holoprosencephaly and hypognathia with two proboscides: Report of a case and review of unusual proboscides
79. A case of cleft lip and palate with polypoid nasal tubercle
80. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
81. Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: Their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos
82. Left-right asymmetric expression of the TGF-β family member lefty in mouse embryos
83. Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal
84. Length of upper extremities in Homo sapiens from birth through adolescence
85. Differences in left-right axis pathways in mouse and chick: Functions of FGF8 and SHH
86. Multiple anomalies possibly caused by a human homologue to the mouse disorganization (Ds) gene
87. Hemimaxillofacial dysplasia: A newly recognized disorder of facial asymmetry, hypertrichosis of the facial skin, unilateral enlargement of the maxilla, and hypoplastic teeth in two patients
88. Hairline indicators of craniofacial clefts
89. Analysis of posterior plagiocephaly: Deformational vs. synostotic
90. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein
91. Editorial comment on the paper by de la Monte and Hutchins on familial polyasplenia
92. A concept of facial esthetics
93. Disorganization: A possible cause of apparent conjoint twinning
94. Molecular mechanisms of vertebrate left-right development
95. Disorganization in mice and humans and its relation to sporadic birth defects
96. Human malformations similar to those in the mouse mutation disorganization (Ds)
97. Pitx2 determines left-right asymmetry of internal organs in vertebrates
98. Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2
99. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
100. Nonrandom laterality of malformations in paired structures
101. Proportions, variability and asymmetries of the long bones of the limbs and the clavicles in man and apes
102. DNA fingerprinting: The utilization of minisatellite probes to detect a somatic mutation in the Proteus syndrome
103. Asymmetric limb malformations induced by drugs and mutant genes
104. Widow's peak scalp-hair anomaly and its relation to ocular hypertelorism
105. Morphogenesis of the murine rods and notechordal plate
106. Molecular motors: The driving force behind mammalian left-right development
107. Another case of the human homologue of the mouse mutant disorganization
108. Anatomical classification of facial, craniofacial and laterofacial clefts
109. ·/· mutant mice unveil a convergence of the Shh and retinoic acid pathways in the control of Lefty-1
110. A new spin on handed asymmetry
111. Developmental anomalies in monozygous twins resembling the human homologue of the mouse mutant disorganization
112. The Proteus syndrome: Partial gigantism of the hands and/or feet, nevi, hemihypertrophy, subcutaneous tumors, macrocephaly or other skull anomalies and possible accelerated growth and visceral affections
113. A possible human homologue for the mouse mutant disorganization
114. Left-right development from embryos to brains
115. Vertebrate left-right development
116. Diverse initiation in a conserved left-right pathway?