Linear Relationships between the Ligand Binding Energy and the Activation Energy of Time-dependent Inhibition of Steroid 5α-Reductase by Δ1-4-Azasteroids

Journal of Biological Chemistry

Volumn 276, Issue 24, 2001, Pages 21359-21364

  Tian, Gaochao ^a,b   Haffner, Curt D ^a  

^a GLAXOSMITHKLINE   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; CORRELATION METHODS; ENZYME INHIBITION; RATE CONSTANTS;

ENERGY BARRIER;

ENZYMES;

17BETA N 1 (3,4 METHYLENEDIOXYPHENYL)CYCLOHEXYLCARBAMOYL 4 AZA 5ALPHA ANDROST 1 EN 3 ONE; 17BETA N 1 (4 CHLOROPHENYL)CYCLOPENTYLCARBAMOYL 4 AZA 5ALPHA ANDROST 1 EN 3 ONE; 17BETA N 1 (4 METHOXYPHENYL)CYCLOHEXYLCARBAMOYL 4 AZA 5ALPHA ANDROST 1 EN 3 ONE; 17BETA N 1 (4 TERT BUTYLPHENYL)CYCLOHEXYLCARBAMOYL 4 AZA 5ALPHA ANDROST 1 EN 3 ONE; AZASTEROID; DUTASTERIDE; FINASTERIDE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG; ENZYME INHIBITOR; LIGAND; PROGESTERONE; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; DRUG SYNTHESIS; ENERGY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; INHIBITION KINETICS; LIGAND BINDING; PRIORITY JOURNAL; TIME; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME ACTIVATION; HUMAN; KINETICS; METABOLISM; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

BRYOPHYTA;

AZASTEROIDS; ENZYME ACTIVATION; ENZYME INHIBITORS; FINASTERIDE; HUMANS; KINETICS; LIGANDS; MOLECULAR STRUCTURE; PROGESTERONE; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE 5-ALPHA-REDUCTASE; THERMODYNAMICS; TIME FACTORS;

EID: 0035877727     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100793200     Document Type: Article

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