High specificity of human orexin receptors for orexins over neuropeptide Y and other neuropeptides

Neuroscience Letters

Volumn 305, Issue 3, 2001, Pages 177-180

  Holmqvist, Tomas ^a   Åkerman, Karl E O ^a   Kukkonen, Jyrki P ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Calcium; Chinese hamster ovary cells; Feeding; Fura 2; Neuropeptide Y; Orexin

Indexed keywords

ALPHA MELANOCORTIN; MELANOCORTIN; NEUROPEPTIDE Y; OREXIN A; OREXIN B; OREXIN OX1 RECEPTOR; OREXIN OX2 RECEPTOR; PANCREAS POLYPEPTIDE; PITUITARY ADENYLYL CYCLASE ACTIVATING PEPTIDE 38; PROTEIN; RECEPTOR; SECRETIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RECEPTOR UPREGULATION;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; CHO CELLS; CRICETINAE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDE Y; NEUROPEPTIDES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SUBSTRATE SPECIFICITY;

EID: 0035876959     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01839-0     Document Type: Article

References (16)

1. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
2. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats
3. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
4. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats
5. Hypothalamic orexin-A binding sites are downregulated by chronic nicotine treatment in the rat
6. Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin
7. The orexin OX1 receptor activates a novel Ca2 + influx pathway necessary for coupling to phospholipase C
8. The role of the N-terminal tetrapeptide in the histamine releasing action of substance P
9. Activation of rat peritoneal mast cells by substance P and mastoparan
10. Structural requirements for neuropeptide Y in mast cell and G protein activation
11. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour
12. Structure and function of human prepro-orexin gene
13. Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR
14. Hypothalamic hypocretin (orexin): Robust innervation of the spinal cord
15. Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin
16. Orexin-induced food intake involves neuropeptide Y pathway