Hairpin ribozymes with four-way helical junctions mediate intracellular RNA ligation

Journal of Molecular Biology

Volumn 309, Issue 4, 2001, Pages 893-902

  Yadava, Ramesh S ^a   Choi, Anthony J ^a   Lebruska, Lori L ^a   Fedor, Martha J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Hairpin ribozyme; Intracellular kinetics; RNA catalysis; RNA folding; RNA ligation

Indexed keywords

RIBOZYME; RNA;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME KINETICS; ENZYME MECHANISM; NONHUMAN; PRIORITY JOURNAL; RNA ANALYSIS; RNA CONFORMATION;

EID: 0035875909     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.4713     Document Type: Article

References (35)

1. RNA secondary structure repression of a muscle-specific exon in HeLa cell nuclear extracts
2. RNA structural patterns and splicing: Molecular basis for an RNA-based enhancer
3. Control of translation by mRNA secondary structure: The importance of the kinetics of structure formation
4. Mutations affecting primer RNA interaction with the replication repressor RNA I in plasmid ColE1: Potential RNA folding pathway mutants
5. RNA folding kinetics regulates translation of phage MS2 maturation gene
6. Mechanical devices of the spliceosome: Motors, clocks, springs, and things
7. Molecular movement inside the translational engine
8. The role of metal ions in RNA biochemistry
9. Protein-facilitated RNA folding
10. RNA chaperones and the RNA folding problem
11. Self-splicing of the Tetrahymena pre-rRNA is decreased by misfolding during transcription
12. Folding of a large ribozyme during transcription and the effect of the elongation factor nusA
13. A ribosomal function is necessary for efficient splicing of the T4 phage thymidylate synthase intron in vivo
14. Kinetics of hairpin ribozyme cleavage in yeast
15. The kinetic mechanism of the hairpin ribozyme in vivo: Influence of RNA helix stability on intracellular cleavage kinetics
16. Structure and function of the hairpin ribozyme
17. Stability of hairpin ribozyme tertiary structure is governed by the interdomain junction
18. The folding of the hairpin ribozyme: Dependence on the loops and the junction
19. Tertiary structure stabilization promotes hairpin ribozyme ligation
20. Kinetics and thermodynamics of intermolecular catalysis by hairpin ribozymes
21. The internal equilibrium of the hairpin ribozyme: Temperature, ion and pH effects
22. Regulation of cell magnesium
23. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure
24. An unusual pH-independent and metal-ion-independent mechanism for hairpin ribozyme catalysis
25. Laser temperature-jump, spectroscopic, and thermodynamic study of salt effects on duplex formation by dGCATGC
26. A replication cycle for viroids and other small infectious RNA's
27. Evidence for spontaneous circle formation in the replication of the satellite RNA of tobacco ringspot virus
28. Use of ribozymes to inhibit gene expression
29. Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-lives
30. RNA repair: A novel approach to gene therapy
31. Trans-splicing ribozymes for targeted gene delivery
32. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
33. Synthesis of small RNAs using T7 RNA polymerase
34. Measurement of mRNA decay rates in Saccharomyces cerevisiae