Epidermal-transformation leads to increased perlecan synthesis with heparin-binding-growth-factor affinity

Biochemical Journal

Volumn 355, Issue 2, 2001, Pages 517-527

  Tapanadechopone, P ^a   Tumova, S ^a   Jiang, X ^a   Couchman, J R ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

Fibroblast growth factors; Heparan sulphate; Proteoglycan; Sulphation

Indexed keywords

BIOLOGICAL MEMBRANES; BIOSYNTHESIS; PROTEINS; RNA; TUMORS;

EPIDERMAL-TRANSFORMATIONS;

BIOCHEMISTRY;

CHONDROITIN SULFATE; FIBROBLAST GROWTH FACTOR; HEPARAN SULFATE; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; PERLECAN;

ANIMAL CELL; ARTICLE; BASEMENT MEMBRANE; CARCINOGENESIS; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURE ANALYSIS;

ANIMALS; BASE SEQUENCE; CARBOHYDRATE CONFORMATION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; DNA PRIMERS; EPIDERMIS; FIBROBLAST GROWTH FACTOR 1; GLYCOSAMINOGLYCANS; HEPARAN SULFATE PROTEOGLYCANS; HEPARIN LYASE; MICE; POLYSACCHARIDE-LYASES; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0035870928     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3550517     Document Type: Article

References (43)

1. Tumor stroma as a regulator of neoplastic behavior. Agonistic and antagonistic elements embedded in the same connective tissue
2. Proteoglycans and neoplasia
3. Altered proteoglycan gene expression and the tumor stroma
4. Differential expression of proteoglycans on the surface of human melanoma cells characterized by altered experimental metastatic potential
5. Heparan sulfate undergoes specific structural changes during the progression from human colon adenoma to carcinoma in vitro
6. Glycosaminoglycans of pleural mesothelioma: A possible biochemical variant containing chondroitin sulfate
7. Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma. Hypomethylation of PG-40 gene correlates with increased PG-40 content and mRNA levels
8. Heparan sulfate proteoglycan expression in human primary liver tumors
9. Bio-specific sequences and domains in heparan sulfate and the regulation of growth and adhesion
10. Abnormal expression of perlecan proteoglycan in metastatic melanoma
11. Morphological aspects of altered basement membrane metabolism in invasive carcinomas of the breast and the larynx
12. Matrix proteoglycans: From molecular design to cellular function
13. Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo
14. Recombinant domain III of perlecan promotes cell attachment through its RGDS sequence
15. Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis and angiogenesis
16. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin and heparinases
17. A role for perlecan in suppression of growth and invasion in fibrosarcoma cells
18. Formation of heparan sulfate or chondroitin/dermatan sulfate on recombinant domain I of mouse perlecan expressed in Chinese hamster ovary cells
19. Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix
20. Identification of sites in domain I of perlecan that regulate heparan sulfate synthesis
21. Regulated diversity of heparan sulfate
22. Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate PG
23. Proteoglycan that activates fibroblast growth factors during early neuronal development is a perlecan variant
24. Structural comparison of fibroblast growth factor-specific heparan sulfates derived from a growing of differentiating neuroepithelial cell line
25. Synergistic inhibition of phorbol ester-induced transformation of JB6 cells by transforming growth factor-β and retinoic acid
26. C-Jun/AP-1 as possible mediators of tumor necrosis factor-alpha-induced apoptotic response in mouse JB6 tumor cells
27. Localization of glycosaminoglycan substitution sites on domain V of mouse perlecan
28. Characterization of dermatan sulfate proteoglycan synthesized by murine parietal yolk sac (PYS-2) cells
29. Structural characterization of the oligosaccharides formed by depolymerization of heparin with nitrous acid
30. A unique heparan sulfate in the nuclei of hepatocytes: Structural changes with the growth state of the cells
31. Analysis of DNA-protein interactions by affinity coelectrophoresis
32. Specificity in the interaction of extracellular matrix proteins with subpopulations of the glycosaminoglycan heparin
33. Coordinated modulation of the fibroblast growth factor dual receptor mechanism during transformation from human colon adenoma to carcinoma
34. Analysis of affinity and structural selectively in the binding of proteins to glycosaminoglycans: Development of a sensitive electrophoretic approach
35. Functions of cell surface heparan sulfate proteoglycan
36. The C-terminal domain V of perlecan promotes beta1 integrin-mediated cell adhesion, binds heparin, nidogen and fibulin-2 and can be modified by glycosaminoglycans
37. Perlecan is essential for cartilage and cephalic development
38. Perlecan maintains the integrity of cartilage and some basement membranes
39. Dermatan sulfate released after injury is a potent promoter of fibroblast growth factor-2 function
40. Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulfate
41. Expression and characterization of human perlecan domains I and II synthesized by baculovirus-infected insect cells
42. The FGF family of growth factors and oncogenes
43. Upregulation of fibroblast growth factors and their receptors during multi-stage epidermal carcinogenesis in K14-HPV16 transgenic mice