Primary hepatocytes from mice treated with IL-2/IL-12 produce T cell chemoattractant activity that is dependent on monokine induced by IFN-γ (Mig) and chemokine responsive to γ-2 (Crg-2)

Journal of Immunology

Volumn 166, Issue 6, 2001, Pages 3763-3770

  Park, J W ^a   Gruys, M E ^a   McCormick, K ^a   Lee, J K ^a   Subleski, J ^a   Wigginton, J M ^a   Fenton, R G ^a   Wang, J M ^a   Wiltrout, R H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 2; MONOKINE;

ANIMAL CELL; ANTIBODY SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION; GENE INDUCTION; HEPATOMA CELL; INFLAMMATION; LIVER CELL; MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; RECEPTOR UPREGULATION; T LYMPHOCYTE;

EID: 0035869588     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.6.3763     Document Type: Article

References (34)

1. Interleukin-12: A cytokine at the interface of inflammation and immunity
2. Interleukin-12 promotes the proliferation and cytolytic maturation of immune effectors: Implications for the immunotherapy of cancer
3. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
4. Antitumor and antimetastatic activity of interleukin 12 against murine tumors
5. Role of interferon-γ in mediating the antitumor efficacy of interleukin-12
6. Recombinant IL-2 administration induces tumor regression in association with IFN-γ production
7. Inhibition of angiogenesis in vivo by interleukin 12
8. A role for the interferon-inducible protein 10 in inhibition of angiogenesis by interleukin-12
9. Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein
10. Contribution of CXC chemokines IP-10 and Mig to the antitumor effects of IL-12
11. Chemokine receptor specific for IP 10 and Mig: Structure, function, and expression in activated T-lymphocytes
12. Mig and IP-10: CXC chemokines that target lymphocytes
13. Chemokines: Signal lamps for trafficking of T and B cells for development and effector function
14. Interferon-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases
15. Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo
16. The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse Renca tumor
17. Administration of interleukin 12 with pulse interleukin 2 and the rapid and complete eradication of routine renal carcinoma
18. Chemokine gene expression in the murine renal carcinoma, Renca, following treatment in vivo with interferon-α and interleukin-2
19. Prediction of Furan pharmacokinetics from hepatocyte studies: Comparison of bioactivation and hepatic dosimetry in rats, mice, and humans
20. NK cell infiltration into lung, liver, and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction
21. LGL a non-polymorphic antigen expressed on a major population of mouse natural killer cells
22. Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver
23. Immune events associated with the cure of established tumors and spontaneous metastasis by local and systemic interleukin 12
24. Tumor cell responses to IFNγ affect tumorigenicity and response to IL-12 therapy and antiangiogenesis
25. The gene for chemokines μMig and Crg-2 are induced in protozoan and viral infections in response to IFN-γ with patterns of tissue expression that suggest nonredundant roles in vivo
26. Recruitment of hepatic NK cells by IL-12 is dependent on IFN-γ and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas
27. Regulation and antimetastatic functions of liver-associated natural killer cells
28. Tissue specific expression of murine IP-10 mRNA following systemic treatment with interferon-γ
29. Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo
30. Macrophages and hepatic cells as chemokine producers in murine listeriosis
31. Cytokine expression in hepatocytes: Role of oxidant stress
32. The IFN-γ receptor: A paradigm for cytokine receptor signaling
33. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIPalpha;)-dependent pathways
34. Complete regression of established spontaneous mammary carcinoma, and the therapeutic prevention of genetically programmed neoplastic transition by IL-12/pulse IL-2: Induction of local T cell infiltration. Fas/Fas ligand gene expression and mammary epithelial apoptosis