Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors

Carcinogenesis

Volumn 21, Issue 6, 2000, Pages 1263-1265

  Ide, Fumio ^a   Iida, Naoko ^a   Nakatsuru, Yoko ^a   Oda, Hideaki ^a   Tanaka, Kiyoji ^b   Ishikawa, Takatoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXCISION REPAIR; FEMALE; GENETIC DISORDER; LUNG ADENOMA; LUNG CARCINOGENESIS; LUNG CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0034123342     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.6.1263     Document Type: Article

References (29)

1. Hoeijmakers, J.H.J. and Bootsma, D. (1990) Molecular genetics of eukaryotic DNA excision repair. Cancer Cells, 2, 311-320.
2. Hoeijmakers, J.H.J. (1993) Nucleotide excision repair, II: from yeast to mammals. Trends Genet., 9, 211-217.
3. Lehmann, A.R. (1995) Nucleotide excision repair and the link with transcription. Trends Biochem. Sci., 20, 402-405.
4. Friedberg, E.C., Walker, G.C. and Siede, W. (1995) DNA Repair and Mutagenesis. American Society for Microbiology Press, Washington, DC.
5. Wood, R.D. (1996) DNA repair in eukaryotes. Annu. Rev. Biochem., 65, 135-167.
6. Cleaver, J.E. and Kraemer, K.H. (1995) Xeroderma pigmentosum and Cockayne syndrome. In Scriver, C.R., Beaudet, A.L., Sly, W.S. and Valle, D. (eds) The Metabolic and Molecular Basis of Inherited Disease. McGraw-Hill, New York, NY, Vol. III, pp. 4393-4419.
7. Kraemer, K.H., Lee, M.M. and Scotto, J. (1984) DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum. Carcinogenesis, 5, 511-514.
8. Takebe,H., Nishigori, C. and Satoh, Y. (1987) Genetics and skin cancer of xeroderma pigmentosum in Japan. Jpn. J. Cancer Res., 78, 1135-1143.
9. Satoh, Y. and Nishigori, C. (1988) Xeroderma pigmentosum: clinical aspects. Gann Monogr. Cancer Res., 35, 113-126.
10. Thielmann, H.W., Popanda, O., Edler, L. and Jung, E.G. (1991) Clinical symptoms and DNA repair characteristics of xeroderma pigmentosum patients from Germany. Cancer Res., 51, 3456-3470.
11. Kraemer, K.H. (1997) Sunlight and skin cancer: another link revealed. Proc. Natl Acad. Sci. USA, 94, 11-14.
12. Nakane, H., Takeuchi, S., Saijo, M., Nakatsu, Y., Murai, H., Nakatsuru, Y., Ishikawa, T., Hirota, S., Kitamura, Y., Kato, Y., Tsunoda, Y., Miyauchi, H., Horio, T., Tokunaga, T., Matsunaga, T., Nikaido, O., Nishimune, Y., Okada, Y. and Tanaka, K. (1995) High incidence of ultraviolet-B- or chemical-carcinogen-induced skin tumors in mice lacking the xeroderma pigmentosum group A gene. Nature, 377, 165-168.
13. De Vries, A., Van Oostrom, C.Th.M., Hofhuis, F.M.A., Dortant, P.M., Berg, R.J.W., De Gruiji, F.R., Wester, P.W., Van Kreijl, C.F., Capel, P.J.A., Van Steeg, H. and Verbeck, S. (1995) Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature, 377, 169-173.
14. Van Steeg, H., Klein, H., Beems, R.B. and Van Kreijl, C.F. (1998) Use of DNA-repair deficient XPA transgenic mice in short-term carcinogenicity testing. Toxicol. Pathol., 26, 742-749.
15. Foley, J.F., Anderson, M.W., Stoner, G.D., Gaul, B.W., Hardisty, J.F. and Maronpot, R.R. (1991) Proliferative lesions of the mouse lung: progression studies in strain A mice. Exp. Lung Res., 17, 157-168.
16. Sands, A., Abuln, A., Sanchez, A., Conti, J.C. and Bradley, A. (1995) High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC. Nature, 377, 162-165.
17. Phillips, D.H. (1983) Fifty years of benzo(a)pyrene. Nature, 303, 468-472.
18. Weinstein, I.B., Jeffrey, A.M., Jenette, K.W., Blobstein, S.H., Harvey, R.G., Harris, C., Autrup, H., Kasai, H. and Nakanishi, K. (1976) Benzo(a)pyrene diol epoxide as intermediates in nucleic acid binding in vitro and in vivo. Science, 193, 592-595.
19. Maher, V.M., Curren, R.D., Ouelette, L.M. and McCormick, J.J. (1976) Role of DNA repair in the cytotoxic and mutagenic action of physical and chemical carcinogens. In De Serres, F.J., Fouts, J.R., Bend, J.R. and Philpot, R.M. (eds) In Vitro Metabolic Activation in Mutagenesis Testing. Elsevier/North-Holland, Amsterdam, The Netherlands, pp. 313-336.
20. Chen, R.-H., Maher, V.M. and McCormick, J.J. (1991) Lack of a cell cycle-dependent strand bias for mutations induced in the HRPT gene by (±)-7β.8α-dihydroxy-9α,10α-epoxy-7,8,9,10- tetrahydrobenzo(a)pyrene in excision repair-deficient human cells. Cancer Res., 51, 2587-2592.
21. Naegeli, H. (1995) Mechanisms of DNA damage recognition in mammalian nucleotide excision repair. FASEB J., 9, 1043-1050.
22. De Vries, A., Van Oostrom, C.Th. M., Dortant, P.M., Beems, R.B., Van Kreijl, C.F., Capel, P.J.A. and Van Steeg, H. (1997) Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice. Mol. Carcinog., 19, 46-53.
23. De Vries, A., Dolle, M.E., Broekhof, J.L., Muller, J.J., Kroese, E.D., Van Kreijl, C.F., Capel, P.J., Vijg, J. and Van Steeg, H. (1997) Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumor development. Carcinogenesis, 18, 2327-2332.
24. Bol.S.A.M., Van Steeg, H., Jansen, J.G., Van Oostrom, C., De Vries, A., De Groot, A.J.L., Tates, Ad.D., Vrieling, H., Van Zeeland, A.A. and Mullenders, L.H.F. (1998) Elevated frequencies of benzo[a]pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice. Cancer Res., 58, 2850-2856.
25. Van Oostrom, C.T., Boeve, M., Van Den Berg, J., De Vries, A., Dolle, M.E., Beems, R.B., Van Kreijl, C.F., Vijg, J. and Van Steeg, H. (1999) Effects of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice. Environ. Mol. Mutagen., 34, 124-130.
26. -/- mice. Cancer Res., 59, 771-775.
27. Massey, T.E., Stewart, R.K., Daniels, J.M. and Liu, L. (1995) Biochemical and molecular aspects of mammalian susceptibility to aflatoxin B1 carcinogenicity. Proc. Soc. Exp. Biol. Med., 208, 213-227.
28. Satoh, M.S., Jones, C.J., Wood, R.D. and Lindahl, T. (1993) DNA excision-repair defect of xeroderma pigmentosum prevents removal of a class of oxygen free radical-induced base lesions. Proc. Natl Acad. Sci. USA, 90, 6335-6339.
29. Reardon, J.T., Bessho, T., Chuan Kung, H., Bolton, P.H. and Sancar, A. (1997) In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients. Proc. Natl Acad. Sci. USA, 94, 9463-9468.