Lipoprotein (a) up-regulates the expression of the plasminogen activator inhibitor 2 in human blood monocytes

Blood

Volumn 97, Issue 4, 2001, Pages 981-986

  Buechler, C ^a   Ullrich, H ^a   Ritter, M ^a   Porsch Oezcueruemez, M ^a   Lackner, K J ^a   Barlage, S ^a   Friedrich, S O ^a   Kostner, G M ^a   Schmitz, G ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; LIPOPROTEIN A; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 2;

ADULT; AGED; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; IN VITRO STUDY; ISCHEMIC HEART DISEASE; MALE; MONOCYTE; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DIFFERENCE;

EID: 0035865605     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V97.4.981     Document Type: Article

References (38)

1. Lipoprotein (a) concentrations as risk indicators for atherosclerosis
2. Lipoprotein(a) in health and disease
3. cDNA sequence of human apolipoprotein (a) is homologous to plasminogen
4. Lipoprotein (a): The link between impaired fibrinolysis and atherosclerosis
5. Effect of individual plasma lipoprotein(a) variations in vivo on its competition with plasminogen for fibrin and cell binding
6. Cellular receptors in the regulation of plasmin generation
7. Retinoic acid stimulates plasminogen activator inhibitor 2 production by blood mononuclear cells and inhibits urokinase-induced extracellular proteolysis
8. Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
9. The dual role of the urokinase receptor system in pericellular proteolysis and cell adhesion: Implications for cardiovascular function
10. uPA, uPAR, PAI-1: Key intersection of proteolytic, adhesive and chemotactic highways?
11. Lipoprotein (a) regulates plasminogen activator inhibitor-1 expression in endothelial cells: A potential mechanism in thrombogenesis
12. Expression of adhesion molecules by Ip(a): A potential novel mechanism for its atherogenicity
13. Effects of lipoprotein(a) on mesangial cell proliferation and viability
14. Altered mononuclear phagocyte differentiation associated with genetic defects of the lysosomal acid lipase
15. Enhanced upregulation of the Fc gamma receptor Illa (CD16a) during in vitro differentiation of ApoE4/E4 monocytes
16. Functionally abnormal monocytes in hypercholesterolemia
17. Peripheral blood mononuclear phagocyte subpopulations as cellular markers in hypercholesterolemia
18. Characterization of inherited scavenger receptor over-expression and abnormal macrophage phenotype in a normolipidemic subject with planar xanthoma
19. Increased expression of u-PA and u-PAR on monocytes by LDL and Lp(a) lipoproteins - Consequences for plasmth generation and monocyte adhesion
20. Oxidized lipoprotein (a) induces cell adhesion molecule Mac-1 (CD 11b) and enhances adhesion of the monocytic cell line U937 to cultured endothelial cells
21. Serial analysis of gene expression in human monocytes and macrophages
22. Discovery and analysis of inflammatory disease-related genes using cDNA microarrays
23. Lipoprotein(a)-apheresis in the secondary prevention of coronary heart disease
24. Preparation of a stable fresh frozen primary lipoprotein(a) (Lp(a)) standard
25. Protein measurement with the folin phenol reagent
26. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
27. Lp(a) lipoprotein as a risk factor for myocardial infarction
28. Lipoprotein(a) in renal disease
29. Lipoprotein(a) impairs generation of plasmin by fibrin-bound tissue-type plasminogen activator: In vitro studies in a plasma milieu
30. Lipoprotein(a): Intrigues and insights
31. Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes
32. Menopause and coronary head disease: The Framingham Study
33. Biological and clinical aspects of plasminogen activator inhibitor type 2
34. Regulation of plasminogen activator inhibitor mRNA levels in lipopolysachcaride-stimulated human monocytes
35. Monocyte plasminogen activator inhibitor 2 (PAI-2) inhibits u-PA-mediated fibrin clot lysis and is cross-linked to fibrin
36. Functional characteristics of receptor-bound urokinase on human monocytes: Catalytic efficiency and susceptibility to inactivation by plasminogen activator inhibitors
37. Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice
38. Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization