Structure-based design of a dimeric RNA-peptide complex

EMBO Journal

Volumn 20, Issue 1-2, 2001, Pages 178-186

  Campisi, D M ^a   Calabro, V ^a   Frankel, A D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bovine immunodeficiency virus; RNA protein interactions; TAR; Tat

Indexed keywords

DIMER; RNA; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS PROTEIN TAR; VIRUS PROTEIN TAT;

ARTICLE; BINDING AFFINITY; BINDING SITE; BOVINE IMMUNODEFICIENCY LIKE VIRUS; COMPLEX FORMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN RNA BINDING; RNA STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATTLE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CLONING, MOLECULAR; DIMERIZATION; GENE PRODUCTS, TAT; HELA CELLS; HIV; HUMANS; IMMUNODEFICIENCY VIRUS, BOVINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; RNA; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035863214     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.1.178     Document Type: Article

References (50)

1. The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein
2. α helix major groove recognition in an HIV-1 Rev peptide RRE-RNA complex
3. Positive and negative regulation of endogenous genes by designed transcription factors
4. Functional differences between human and bovine immunodeficiency virus Tat transcription factors
5. Solution structure of P22 transcriptional antitermination N peptide-box B RNA complex
6. Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition
7. An RNA-binding peptide from bovine immunodeficiency virus Tat protein recognizes an unusual RNA structure
8. A peptide interaction in the major groove of RNA resembles protein interactions in the minor groove of DNA
9. Sequence-specific DNA recognition by polyamides
10. Themes in RNA-protein recognition
11. Getting a grip on DNA recognition: Structures of the basic region leucine zipper and the basic region helix-loop-helix DNA-binding proteins
12. Fitting peptides into the RNA world
13. Specific RNA binding proteins constructed from zinc fingers
14. A general strategy for selecting high-affinity zinc finger proteins for diverse DNA sites
15. Selection of RNA-binding peptides in vivo
16. Molding a peptide into an RNA site by in vivo peptide evolution
17. Stitching together RNA tertiary architectures
18. Non-Watson-Crick base pairs in RNA-protein recognition
19. Single-chain λ Cro repressors confirm high intrinsic dimer-DNA affinity
20. Anchoring an extended HTLV-1 Rex peptide within an RNA major groove containing junctional base triples
21. Getting a handhold on DNA: Design of poly-zinc finger proteins with femtomolar dissociation constants
22. Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression
23. DNA specificity enhanced by sequential binding of protein monomers
24. Analysis of RNA-binding proteins by in vitro genetic selection: Identification of an amino acid residue important for locking U1A onto its RNA target
25. NMR structure of the bacteriophage λ N peptide/boxB RNA complex: Recognition of a GNRA fold by an arginine-rich motif
26. Structure-based design of an RNA-binding zinc finger
27. Rationally designed helix-turn-helix proteins and their conformational changes upon DNA binding
28. Structure-based design of a dimeric zinc finger protein
29. Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex
30. Structural determinants of nuclear receptor assembly on DNA direct repeats
31. Covalent attachment of Arc repressor subunits by a peptide linker enhances affinity for operator DNA
32. Optimizing the stability of single-chain proteins by linker length and composition mutagenesis
33. Crystal structures of a series of RNA aptamers complexed to the same protein target
34. Design of novel sequence-specific DNA-binding proteins
35. Altering the context of an RNA bulge switches the binding specificities of two viral Tat proteins
36. An RNA-binding chameleon
37. Structural variety of arginine-rich RNA-binding peptides
38. A novel glutamine-RNA interaction identified by screening libraries in mammalian cells
39. RNA recognition by an isolated α helix
40. Electrostatic interactions modulate the RNA-binding and transactivation specificities of the human immunodeficiency virus and simian immunodeficiency virus Tat proteins
41. Crystal structure of an RNA bacteriophage coat protein-operator complex
42. The NMR structure of the 38 kDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein
43. Aminoglycoside-RNA interactions
44. Major groove accessibility of RNA
45. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA
46. Molecular recognition in the bovine immunodeficiency virus Tat peptide-TAR RNA complex
47. Deep penetration of an α-helix into a widened RNA major groove in the HIV-1 rev peptide-RNA aptamer complex
48. RNA architecture dictates the conformations of a bound peptide
49. Highly specific DNA recognition by a designed miniature protein
50. On finding all suboptimal foldings of an RNA molecule