Lack of UGT1 isoforms in Gunn rats changes metabolic ratio and facilitates excretion of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Toxicology and Applied Pharmacology

Volumn 170, Issue 2, 2001, Pages 137-143

  Dietrich, Christoph G ^a   Ottenhoff, Roelof ^a   De Waart, D Rudi ^a   Oude Elferink, Ronald P J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Gunn rat; Metabolism; PhIP; Sulfotransferases; UDP glucuronosyltransferases

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; CARCINOGEN; DRUG METABOLITE; GLUCURONOSYLTRANSFERASE; ISOENZYME; SULFOTRANSFERASE; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGENIC ACTIVITY; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG DETOXIFICATION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG URINE LEVEL; ENZYME ACTIVITY; FEMALE; NONHUMAN; RAT; TOXICOKINETICS; XENOBIOTIC METABOLISM;

EID: 0035862769     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2000.9090     Document Type: Article

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