Low-copy-number human transgene is recognized as an X inactivation center in mouse ES cells, but fails to induce cis-inactivation in chimeric mice

Genomics

Volumn 71, Issue 2, 2001, Pages 156-162

  Migeon, Barbara R ^a   Winter, Holly ^a   Kazi, Ethan ^a   Chowdhury, Ashis K ^a   Hughes, Aisha ^a   Haisley Royster, Camille ^a   Morrison, Harris ^b   Jeppesen, Peter ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE INACTIVATION; GENE INDUCTION; GENE LOCUS; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; STEM CELL; TRANSGENE; X CHROMOSOME INACTIVATION;

MAMMALIA; MURINAE;

EID: 0035862543     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.2000.6421     Document Type: Article

References (26)

1. The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus
2. Stabilization and localization of XIST RNA are controlled by separate mechanisms and are not sufficient for X inactivation
3. RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear/chromosome structure
4. Xist yeast artificial chromosome transgenes function as X-inactivation centers only in multicopy arrays and not as single copies
5. Human XIST yeast artificial transgenes show partial X inactivation center function in mouse embryonic stem cells
6. Identification and characterization of the human XIST gene promoter: Implications for models of X chromosome inactivation
7. Xist has properties of the X-chromosome inactivation centre
8. A revision of the human XIST gene organization and structural comparison with mouse Xist
9. The inactive X chromosomes in female mammals is distinguished by a lack of histone H4 acetylation
10. Fluorescent detection of nuclear RNA and DNA: Implications for genomic organization
11. X-inactivation and histone H4 acetylation in embryonic stem cells
12. 2.6 Mb YAC contig of the human X inactivation center region in Xq13: Physical linkage of the RPS4X, PHKA1, XIST and DXS128E genes
13. Long-range cis effects of ectopic X-inactivation centres on a mouse autosome
14. Genetic analysis of the mouse X-inactivation center reveals an 80 kb multifunction domain
15. A 450 kb transgene displays properties of the mammalian X-inactivation center
16. Mapping the distal boundaries of the X-inactivation center in a rearranged X chromosome from a female expressing XIST
17. X-chromosome inactivation: A repeat hypothesis
18. Xist-deficient mice are defective in dosage compensation but not spermatogenesis
19. X-chromosome inactivation: Molecular mechanisms and genetic consequences
20. Human X inactivation center induces random X inactivation in male transgenic mice
21. The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation
22. Deficient transcription of XIST from tiny ring X chromosomes in females with severe phenotypes
23. X chromosome inactivation is mediated by Xist RNA stabilization
24. DNA hypomethylation can activate Xist expression and silence X-linked genes
25. Requirements for Xist in X chromosome inactivation