HMG-CoA reductase inhibitors reduce adhesion of human monocytes to endothelial cells

Biochemical and Biophysical Research Communications

Volumn 289, Issue 4, 2001, Pages 838-844

  Teupser, Daniel ^a   Bruegel, Mathias ^a   Stein, Olga ^b   Stein, Yechezkiel ^c   Thiery, Joachim ^a  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b HEBREW UNIVERSITY   (Israel)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Atherosclerosis; Cell adhesion molecules; Cholesterol; Endothelium; Monocytes

Indexed keywords

ATORVASTATIN; CERIVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; ATHEROGENESIS; CELL ADHESION; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; ISCHEMIC HEART DISEASE; MONOCYTE; PRIORITY JOURNAL;

EID: 0035861964     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6066     Document Type: Article

References (33)

1. Statins do more than just lower cholesterol
2. Non-lipid-related effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
3. Methods and endpoint issues in clinical development of lipid-acting agents with pleiotropic effects
4. New insights into the pharmacodynamic and pharmacokinetic properties of statins
5. Low-density lipoprotein-independent effects of statins
6. Atherosclerosis - An inflammatory disease
7. The pathogenesis of atherosclerosis: A perspective for the 1990s
8. Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line
9. Lovastatin reduces expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells
10. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia
11. Activation status and function of the VLA-4 (alpha4betal) integrin expressed on human melanoma cell lines
12. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells
13. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA
14. Human 3-hydroxy-3-methylglutaryl coenzyme A reductase. Conserved domains responsible for catalytic activity and sterol-regulated degradation
15. The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
16. Scavenger receptor activity is increased in macrophages from rabbits with low atherosclerotic response: Studies in normocholesterolemic high and low atherosclerotic response rabbits
17. Atorvastatin reduces NF-kappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells
18. HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis
19. Effects of fluvastatin on leukocyte-endothelial cell adhesion in hypercholesterolemic rats
20. BAYw6228 suppresses accumulation of macrophages in balloon-induced intimal thickening of rabbit carotid artery
21. Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae
22. HMG-CoA reductase inhibitor modulates monocyte-endothelial cell interaction under physiological flow conditions in vitro: Involvement of Rho GTPase-dependent mechanism
23. Cerivastatin suppresses lipopolysaccharide-induced ICAM-1 expression through inhibition of Rho GTPase in BAEC
24. Effect of the new HMG-CoA reductase inhibitor cerivastatin (BAY W 6228)on migration, proliferation and cholesterol synthesis in arterial myocytes
25. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium
26. Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesion and at sites predisposed to lesion formation
27. Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions
28. Integrin mediated adhesion of mononuclear cells from patients with familial hypercholesterolemia
29. Monocytes from patients with combined hypercholesterolemia-hypertriglyceridemia and isolated hypercholesterolemia show an increased adhesion to endothelial cells in vitro. II. Influence of intrinsic and extrinsic factors on monocyte binding
30. Effect of simvastatin on monocyte adhesion molecule expression in patients with hypercholesterolemia
31. Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5′-methylthioadenosine: Roles of protein isoprenylation and carboxyl methylation reactions
32. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages
33. Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: Results of AFCAPS/TexCAPS