Binding of the glutamate carboxypeptidase II (NAALADase) inhibitor 2-PMPA to rat brain membranes

European Journal of Pharmacology

Volumn 427, Issue 2, 2001, Pages 91-96

  Tiffany, Carol W ^a   Cai, Ning S ^a   Rojas, Camilo ^a   Slusher, Barbara S ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

3H 2 (phosphonomethyl) pentanedioic acid ( 3H 2 PMPA); Glutamate carboxypeptidase; Glutamate carboxypeptidase II (NAALADase); N acetylaspartylglutamate (NAAG); Prostate specific membrane antigen

Indexed keywords

2 PHOSPHONOMETHYLPENTANE 1,5 DIOIC ACID; CHLORIDE; COBALT; ENZYME INHIBITOR; GAMMA GLUTAMYL HYDROLASE; GLUTAMATE CARBOXYPEPTIDASE II INHIBITOR; GLUTAMIC ACID; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; QUISQUALIC ACID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL TISSUE; ARTICLE; BINDING SITE; BIOASSAY; BRAIN MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVITY; EQUILIBRIUM CONSTANT; HUMAN; HUMAN TISSUE; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; SCATCHARD PLOT; SCREENING TEST; STIMULATION; TISSUE SPECIFICITY;

ANIMALS; ANTIGENS, SURFACE; BINDING, COMPETITIVE; BRAIN; CARBOXYPEPTIDASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMATE CARBOXYPEPTIDASE II; HUMANS; KIDNEY; LIVER; MALE; MEMBRANES; ORGANOPHOSPHORUS COMPOUNDS; PROSTATE; RATS; SPINAL CORD; TIME FACTORS; TRITIUM;

EID: 0035860488     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01236-5     Document Type: Article

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