Lipid extraction and iontophoretic transport of leuprolide acetate through porcine epidermis

International Journal of Pharmaceutics

Volumn 215, Issue 1-2, 2001, Pages 241-249

  Rastogi, Sumeet K ^a   Singh, Jagdish ^a  

^a NORTH DAKOTA STATE UNIVERSITY   (United States)

Author keywords

Iontophoresis; Leuprolide acetate; Lipid extraction; Permeability; Porcine skin

Indexed keywords

ACETIC ACID ESTER; ACETIC ACID ETHYL ESTER; BUTYL ACETATE; CHLOROFORM; HEXYL ACETATE; LEUPRORELIN; METHANOL; METHYL ACETATE; OCTYL ACETATE; PENTYL ACETATE; PROPYL ACETATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG PENETRATION; DRUG TRANSPORT; IN VITRO STUDY; INFRARED SPECTROSCOPY; IONTOPHORESIS; NONHUMAN; PRIORITY JOURNAL; SKIN PENETRATION; STRATUM CORNEUM; SWINE;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EXCIPIENTS; IONTOPHORESIS; LEUPROLIDE; LIPIDS; PEPTIDES; PERMEABILITY; PROTEINS; SKIN; SPECTROPHOTOMETRY, ULTRAVIOLET; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SWINE;

EID: 0035857712     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00697-9     Document Type: Article

References (43)

1. Effect of organic solvents on in vitro human skin water barrier function
2. Pulmonary delivery of peptide drugs: Effects of particle size on the bioavailability of leuprolide acetate in healthy male volunteers
3. Leuprolide and other LH-RH analogues
4. Effect of penetration enhancers and iontophoresis of the ultrastructure and cholecytokinin-8 permeability through porcine skin
5. Effect of penetration enhancers and iontophoresis on the FT-IR spectroscopy and LHRH permeability through porcine skin
6. Pig ear skin as a model for predicting percutaneous absorption in man
7. Mechanism of transport enhancement of LHRH through porcine epidermis by terpenes and iontophoesis: Permeability and lipid extraction studies
8. Examination of the effect of ethanol on human stratum corneum in vivo using infrared spectroscopy
9. Determination of percutaneous absorption by in vitro techniques
10. Characterisation of permselective properties of excised human skin during iontophoresis
11. Polymorphic phase behavior of phospholipid membranes studied by infrared spectroscopy
12. Mechanism of skin penetration enhancers: Ethyl acetate
13. Visualizing the pathways of iontophoretic current flow in real time with laser-scanning confocal microscopy and the vibrating probe electrode
14. Sites of iontophoretic current flow into the skin: Identification and characterisation with the vibrating probe electrode
15. Percutaneous transport in relation to stratum corneum structure and lipid composition
16. Simple alkyl esters as skin penetration enhancers
17. Simple alkyl esters as skin penetration enhancers
18. The effects of formulation variables on iontophoretic transdermal delivery of leuprolide to humans
19. Enhanced permeation of polar compounds through human epidermis. I. Permeability and membrane structural change in the presence of short-chain alcohols
20. Lipid content and lipid type as determinants of the epidermal permeability barrier
21. Correction of perfusate concentration for sample removal
22. Preparation of isolated sheets of human stratum corneum
23. Effect of ethanol/propylene glycol on the in vitro percutaneous absorption of aspirin, biophysical changes and macroscopic barrier properties of the skin
24. Techniques for studying skin penetration
25. Cutaneous permeation of lipophilic molecules: Effects of enhancers
26. Mechanisms of sebum production and delivery in man
27. Ultrastructural evaluation of the porcine integument
28. The integument
29. Identification of the pathway of iontophoretic drug delivery: Light and ultrastructural studies using mercuric chloride in pigs
30. The pig as a model for cutaneous pharmacology and toxicology research
31. Effects of various enhancers on transdermal penetration of indomethacin and urea, and relationship between penetration parameters and enhancement factors
32. Fragrance raw materials monographs: Ethyl acetate
33. The role of protein and lipid domains in the uptake of solutes by human stratum corneum
34. Mechanism of percutaneous absorption. I. Routes of penetration and the influence of solubility
35. Skin as barrier
36. Quantification of leuprolide acetate by high performance liquid chromatography
37. Iontophoresis of polypeptides: Effect of ethanol pretreatment of human skin
38. The role of lipids in the epidermal barrier to water diffusion
39. In vivo animal models for percutaneous absorption
40. Terpenes and the lipid-protein-partitioning theory of skin penetration enhancement