Neurovascular interactions between aldose reductase and angiotensin-converting enzyme inhibition in diabetic rats

European Journal of Pharmacology

Volumn 417, Issue 3, 2001, Pages 223-230

  Cotter, Mary A ^a   Mirrlees, Don J ^b   Cameron, Norman E ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Aldose reductase; Angiotensin converting enzyme; Blood flow; Diabetic; Nerve conduction; Neuropathy; Rat

Indexed keywords

3',5' DIMETHYL 2 (2 METHYLPHENYL) 4' (NITROMETHYLSULFONYL)ACETANILIDE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; DIPEPTIDYL CARBOXYPEPTIDASE; FRUCTOSE; LISINOPRIL; NITRIC OXIDE; POLYOL; SORBITOL; STREPTOZOCIN; ZD 5122;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG POTENTIATION; ENZYME INHIBITION; MALE; MOTOR NERVE CONDUCTION; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; STREPTOZOCIN DIABETES; VASOCONSTRICTION; VASODILATATION;

ACETANILIDES; ALDEHYDE REDUCTASE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; LISINOPRIL; NEURAL CONDUCTION; RATS; REGIONAL BLOOD FLOW; SCIATIC NERVE; SULFONES; VASODILATION;

EID: 0035853427     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00909-8     Document Type: Article

References (45)

1. Modulation of angiotensin-converting enzyme by nitric oxide
2. Contraction and relaxation of aortas from diabetic rats: Effects of chronic anti-oxidant and aminoguanidine treatments
3. Oxidative stress and Na/K ATPase activity in diabetic rats: Aldose reductase inhibitor withdrawal studies
4. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury for nitric oxide and superoxide
5. Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: Role of polyol pathway activity
6. Contraction and relaxation of aortas from galactosaemic rats and the effects of polyol pathway inhibition
7. Effects of a non-peptide endothelin-1 ETA antagonist on neurovascular function in diabetic rats: Interaction with the renin-angiotensin system
8. Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes
9. New therapeutic approaches to prevent or halt the progression of the long-term complications of diabetes mellitus: Focus on neuropathy
10. The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats
11. Nerve blood flow in early experimental diabetes in rats: Relation to conduction deficits
12. Angiotensin-converting enzyme inhibition prevents the development of muscle and nerve dysfunction and stimulates angiogenesis in streptozotocin-diabetic rats
13. Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats
14. Aldose reductase inhibition, nerve perfusion, oxygenation and function in streptozotocin-diabetic rats: Dose-response considerations and independence from a myo-inositol mechanism
15. Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats
16. Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats
17. Effects of α-lipoic acid on neurovascular function in diabetic rats: Interaction with essential fatty acids
18. +-ATPase activity and glutathione content in diabetic rats
19. Effect of lisinopril on progression of retinopathy in normotensive people with type 1 diabetes
20. Diabetes-associated mesenteric vascular hypertrophy is attenuated by angiotensin-converting enzyme inhibition
21. 2 clearance curves used to measure blood flow in rat sciatic nerve
22. Randomised placebo-controlled trial of lisinopril in normotensive patients with insulin-dependent diabetes and normoalbuminuria or microalbuminuria
23. Effect of a potent new aldose reductase inhibitor (5-(3-thienyl)tetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats
24. 2 balance in the diabetic rat: Influence of vitamin E
25. Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta
26. Effect of diabetes and treatment with the antioxidant, α-lipoic acid, on endothelial and neurogenic responses of corpus cavernosum in rats
27. Effects of chelator treatment on aorta and corpus cavernosum from diabetic rats
28. Effects of aldose reductase inhibition on responses of the corpus cavernosum and mesenteric vascular bed of diabetic rats
29. Altered vasoreactivity to angiotensin II in experimental diabetic neuropathy: Role of nitric oxide
30. Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: Randomised double-blind controlled trial
31. Angiotensin II receptor blockade improves nerve function, modulates nerve blood flow and stimulates endoneurial angiogenesis in streptozotocin-diabetic rats
32. 1 receptor antagonist
33. Effects of diabetes on reactivity of sciatic vasa nervorum in rats
34. Evaluation of a sorbitol dehydrogenase inhibitor on diabetic peripheral nerve metabolism: A prevention study
35. Improvement in endothelial function by angiotensin-converting enzyme inhibition in insulin-dependent diabetes mellitus
36. Fosinopril improves regulation of vascular tone in mesenteric bed of diabetic rats
37. Protein kinase C mediates angiotensin II-induced contractions and the release of endothelin and prostacyclin in rat aortic rings
38. Localization of a constitutively active, phagocyte-like NADPH oxidase in rabbit aortic adventitia: Enhancement by angiotensin II
39. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat heart: Influence of tocopherol as antioxidant
40. Osmotically induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy
41. Properties of ICI 128,436, a novel aldose reductase inhibitor and its effects on diabetic complications in the rat
42. Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta
43. Vascular factors in diabetic neuropathy
44. Endoneurial blood flow and oxygen tension in the sciatic nerves of rats with experimental diabetic neuropathy
45. 2) synthesis by aortic rings from rats with streptozotocin-induced diabetes