Synthesis of novel, potent, diol-based HIV-1 protease inhibitors via intermolecular pinacol homocoupling of (2S)-2-benzyloxymethyl-4-phenylbutanal

Journal of Medicinal Chemistry

Volumn 44, Issue 21, 2001, Pages 3407-3416

  Muhlman A ^a   Lindberg, J ^b   Classon, B ^a,c   Unge, T ^b   Hallberg, A ^b   Samuelsson, B ^a,c  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c MEDIVIR AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYLOXYMETHYL 4 PHENYLBUTANAL; AMPRENAVIR; ANTIRETROVIRUS AGENT; BUTYRALDEHYDE; INDINAVIR; N1,N6 BIS(HYDROXYINDANYL) 3,4 DIHYDROXY 2,4 BIS(2 PHENYLETHYL)HEXANEDIAMIDE; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; REACTION ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

AMIDES; CELL LINE; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; CYTOPATHOGENIC EFFECT, VIRAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035846128     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0011171     Document Type: Article

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