The Wilms tumor suppressor gene wt1 is required for development of the spleen

Current Biology

Volumn 9, Issue 15, 1999, Pages 837-840

  Herzer, Ute ^a   Crocoll, Alexander ^a   Barton, Debra ^a   Howells, Norma ^a   Englert, Christoph ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; APOPTOSIS; CROSSING; DEVELOPMENTAL GENETICS; GENE EXPRESSION REGULATION; GENE MUTATION; HEMATOPOIETIC CELL; HOMEOBOX; IN SITU HYBRIDIZATION; MOUSE; ORGANOGENESIS; PHENOTYPE; SPLEEN; TUMOR SUPPRESSOR GENE;

ANIMALIA; MAMMALIA;

EID: 0033615072     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80369-8     Document Type: Article

References (20)

1. Hastie ND: The genetics of Wilms' tumor - A case of disrupted development. Annu Rev Genet 1994, 28:523-558.
2. Ladanyi M, Gerald W: Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res 1994, 54:2837-2840.
3. Pelletier J, Bruening W, Kashtan CE, Mauer SM, Manivel JC, Striegel JE, et al.: Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome. Cell 1991, 67:437-447.
4. Barbaux S, Niaudet P, Gubler MC, Grunfeld JP, Jaubert F, Kuttenn F, et al.: Donor splice-site mutations in WT1 are responsible for Frasier syndrome. Nat Genet 1997, 17:467-470.
5. Kikuchi H, Takata A, Akasaka Y, Fukuzawa R, Yoneyama H, Kurosawa Y, et al.: Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome? J Med Genet 1998, 35:45-48.
6. Klamt B, Koziell A, Poulat F, Wieacker P, Scambler P, Berta P, et al: Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms. Hum Mol Genet 1998, 7:709-714.
7. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, et al.: WT-1 is required for early kidney development. Cell 1993, 74:679-691.
8. Dear TN, Colledge WH, Carlton MB, Lavenir I, Larson T, Smith AJ, et al.: The Hox11 gene is essential for cell survival during spleen development Development 1995, 121:2909-2915.
9. Roberts CW, Shutter JR, Korsmeyer SJ: Hox11 controls the genesis of the spleen. Nature 1994, 368:747-749.
10. Armstrong JF, Pritchard-Jones K, Bickmore WA, Hastie ND, Bard JB: The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo. Mech Dev 1992, 40:85-97.
11. Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gosden C, et al.; The candidate Wilms' tumour gene is involved in genitourinary development. Nature 1990, 346:194-197.
12. Rackley RR, Flenniken AM, Kuriyan NP, Kessler PM, Stoler MH, Williams BR: Expression of the Wilms' tumor suppressor gene WT1 during mouse embryogenesis. Cell Growth Differ 1993, 4:1023-1031.
13. Englert C: WT1 - More than a transcription factor? Trends Biochem Sci 1998, 23:389-393.
14. Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, et al: Targeted disruption of mouse EGF receptor: Effect of genetic background on mutant phenotype. Science 1995, 269:230-234.
15. Sibilia M, Wagner EF: Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 1995, 269:234-238.
16. Moore AW, McInnes L, Kreidberg J, Hastie ND, Schedl A: YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis. Development 1999, 126:1845-1857.
17. Gray's Anatomy. Edited by Williams PL. Edinburgh, UK: Churchill Livingstone, 1995.
18. Maheswaran S, Englert C, Bennett P, Heinrich G, Haber DA: The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis. Genes Dev 1995, 9:2143-2156.
19. Gerald WL, Rosai J, Ladanyi M: Characterization of the genomic breakpoint and chimeric transcripts in the EWS-WT1 gene fusion of desmoplastic small round cell tumor. Proc Natl Acad Sci USA 1995, 92:1028-1032.
20. Roberts CW, Sonder AM, Lumsden A, Korsmeyer SJ: Development expression of Hox11 and specification of splenic cell fate. Am J Pathol 1995, 146:1089-1101.