Local adenovirus-mediated delivery of hirudin in a rabbit arterial injury model

Journal of Vascular Research

Volumn 36, Issue 5, 1999, Pages 343-352

  Bishop, Gregory G ^a   Wiegman, Pete ^a   McNamara, Coleen ^a   Din, Salah ^a   Sanders, John ^a   Hesselbacher, Sean ^a   Feldman, Mike ^a   McPherson, John A ^a   Humphries, John E ^a   Hammarskjold, Marie Louise ^a   Gimple, Lawrence W ^a   Ragosta, Michael ^a   Powers, Eric R ^a   Dickek, David ^b   Owens, Gary K ^a   Sarembock, Ian J ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

Adenovirus; Hirudin; Inflammation; Rabbit; Restenosis

Indexed keywords

BETA GALACTOSIDASE; CHOLESTEROL; DRUG VEHICLE; FIBRINOGEN; FIBRINOPEPTIDE A; HIRUDIN; THROMBIN; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL WALL; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMORAL ARTERY; GENE DELETION; GENE TARGETING; GENETIC TRANSDUCTION; HYPERCHOLESTEROLEMIA; INTRAVENOUS DRUG ADMINISTRATION; LYMPHOCYTIC INFILTRATION; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; RABBIT; REVIEW;

ADENOVIRUSES, HUMAN; ANGIOPLASTY, BALLOON; ANIMALS; ANTITHROMBINS; ARTERIOSCLEROSIS; DISEASE MODELS, ANIMAL; FEMORAL ARTERY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HIRUDIN THERAPY; HIRUDINS; HUMANS; RABBITS; THROMBIN;

EID: 0032716754     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000025671     Document Type: Review

References (46)

1. Libby P, Schwartz D, Brogi E, Tanaka H, Clinton SK: A cascade model for restenosis. A special case of atherosclerosis progression. Circulation 1992;86(suppl III):III-47-III-52.
2. Barry WL, Gimple LW, Humphries JE, Powers ER, McCoy KW, Sanders JM, et al: Arterial thrombin activity after angioplasty in an atherosclerotic rabbit model: Time course and effect of hirudin. Circulation 1996;94/1:88-93.
3. McNamara CA, Sarembock IJ, Gimple LW, Fenton JW, Owens GK: Human thrombin receptor-activating peptide-induced proliferation of cultured vascular smooth muscle cells exhibits species specificity. Drug Dev Res 1995;35:7-12.
4. Stouffer GA, Sarembock IJ, McNamara CA, Gimple LW, Owens GK: Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA. Am J Physiol 1993;265:C806-C811.
5. Sarembock IJ, Gertz SD, Gimple LW, Owen RM, Powers ER, Roberts WC: Effectiveness of recombinant desulphatohirudin in reducing restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits. Circulation 1991;84/1:232-243.
6. Thome LM, Gimple LW, Bachhuber BG, McNamara CA, Rogosta M, Gertz SD, et al: Early plus delayed hirudin infusion reduces restenosis in the atherosclerotic rabbit more than early administration alone: Potential implications for dosing of antithrombin agents. Circulation 1998;98:2301-2306.
7. Gallo R, Padurean A, Toschi V, Bichler J, Fallon JT, Chesebro JH, et al: Prolonged thrombin inhibition reduces restenosis after balloon angioplasty in porcine coronary arteries. Circulation 1998;97:581-588.
8. Serruys PW, Herrman JP, Simon R, Rutsch W, Bode C, Laarman GJ, et al: A comparison of hirudin with heparin in the prevention of restenosis after coronary angioplasty. Helvetica Investigators. N Engl J Med 1995;333:757-763.
9. Bittl JA, Strony J, Brinker JA, Ahmed WH, Meckel CR: Treatment with bivalirudin (Hirulog) as compared with heparin during coronary angioplasty for unstable or postinfarction angina. N Engl J Med 1995;333:764-769.
10. Rade JJ, Schulick AH, Virmani R, Dichek DA: Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury. Nat Med 1996;2/3: 293-298.
11. DeYoung MB, Dichek DA: Gene therapy for restenosis. Are we ready? Circ Res 1998;82: 306-313.
12. Libby P: Gene therapy of restenosis. Promise and perils. Circ Res 1998;82:404-406.
13. Newman KD, Dunn PF, Owens JW, Schulick AH, Virmani R, Sukhova G, et al: Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest 1995;96:2955-2965.
14. Gerdes C, Faber-Steinfeld V, Yalkinoglu O, Wohlfeil S: Comparison of the effects of the thrombin inhibitor r-hirudin in four animal models of neointima formation after arterial injury. Arterioscler Thromb Vasc Biol 1996;16: 1306-1311.
15. Walters TK, Gorog DA, Wood RF: Thrombin generation following arterial injury is a critical initiating event in the pathogenesis of the proliferative stages of the atherosclerotic process. J Vasc Res 1994;31/3:173-177.
16. Graham FL, Prevec L: Manipulation of adenovirus vectors; in Murray EJ (ed): Methods in Molecular Biology, vol 7: Gene Transfer and Expression Protocols. Clifton, Humana Press, 1991, pp 109-128.
17. Schulick AH, Newman KD, Virmani R, Dichek DA: In vivo gene transfer into injured carotid arteries. Optimization and evaluation of acute toxicity. Circulation 1995;91:2407-2414.
18. Sarembock IJ, LaVeau PJ, Sigal SL, Timms I, Sussman J, Haudenschild C, et al: Influence of inflation pressure and balloon size on the development of intimal hyperplasia after balloon angioplasty. A study in the atherosclerotic rabbit. Circulation 1989;80:1029-1040.
19. Russell HKJ: A modification of Movat's pentachrome stain. Arch Pathol 1972;94/2:187-191.
20. Schwartz RS, Huber KC, Murphy JG: Restenosis and the proportional neointimal response to coronary artery injury: Results in a porcine model. J Am Coll Cardiol 1992;19/2:267-274.
21. Bustos C, Hernandez-Presa MA, Ortego M, Tunon J, Ortega L, Perez F, Diaz C, Hernandez G, Egido J: HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation. J Am Coll Cardiol 1998;32:2057-2064.
22. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R: Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987;316:1371-1375.
23. Barry WL, Wiegman PJ, Gimple LW, Gertz SD, Powers ER, Owens GK, et al: A new single-injury model of balloon angioplasty in cholesterol-fed rabbits: Beneficial effect of hirudin and comparison with double-injury model. Lab Invest 1997;77/1:109-116.
24. Feldman LJ, Steg PG, Zheng LP, Chen D, Kearney M, McGarr SE, et al: Low efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit. J Clin Invest 1995;95:2662-2671.
25. Steg PG, Feldman LJ, Scoazec JY, Tahlil O, Barry JJ, Boulechfar S, et al: Arterial gene transfer to rabbit endothelial and smooth muscle cells using percutaneous delivery of an adenoviral vector. Circulation 1994;90:1648-1656.
26. Sata M, Perlman H, Muruve DA, Silver M, Ikebe M, Libermann TA, et al: Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response. Proc Nat Acad Sci USA 1998;95:1213-1217.
27. Schulick AH, Vassalli G, Dunn PF, Dong G, Rade JJ, Zamarron C, et al: Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity. J Clin Invest 1997;99/2:209-219.
28. Bevilacqua MP: Endothelial-leukocyte adhesion molecules. Annu Rev Immunol 1993;11: 767-804.
29. Li H, Cybulsky MI, Gimbrone MA Jr, Libby P: Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma. Am J Pathol 1993;143:1551-1559.
30. Tanaka H, Sukhova G, Swanson S, Clinton S, Ganz P, Cybulsky M, et al: Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury. Circulation 1993; 88:1788-1803.
31. Blotnick S, Peoples GE, Freeman MR, Eberlein TJ, Klagsburn M: T lymphocyte synthesize and export heparin-binding epidermal growth-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: Differential production and release by CD4+ and CD8+ T cells. Proc Nat Acad Sci USA 1994;91:2890-2894.
32. Ginsberg HS: The ups and downs of adenovirus vectors. Bull NY Acad Med 1996;73/1:53-58.
33. Engelhardt JF, Ye X, Doranz B, Wilson JM: Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Nat Acad Sci USA 1994;91:6196-6200.
34. Kochanek S, Clemens PR, Mitani K., Chen HH, Chan S, Caskey CT: A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc Nat Acad Sci USA 1996;93: 5731-5736.
35. Lieber A, He CY, Kirillova I, Kay MA: Recombinant adenoviruses with large deletions generated by Cre-mediated excision exhibit different biological properties compared with first-generation vectors in vitro and in vivo. J Virol 1996;70:8944-8960.
36. Chen HH, Mack LM, Kelly R, Ontell M, Kochanek S, Clemens PR: Persistence in muscle of an adenoviral vector that lacks all viral genes. Proc Nat Acad Sci USA 1997;94:1645-1650.
37. Wilson CB, Embree LJ, Schowalter D, Albert R, Aruffo A, Hollenbaugh D, et al: Transient inhibition of CD28 and CD40 ligand interactions prolongs adenovirus-mediated transgene expression in the lung and facilitates expression after secondary vector administration. J Virol 1998;72:7542-7550.
38. Jooss K, Turka LA, Wilson JM: Blunting of immune responses to adenoviral vectors in mouse liver and lung with CTLA4Ig. Gene Ther 1998;5:309-319.
39. Clesham GJ, Adam PJ, Proudfoot D, Flynn PD, Efstathiou S, Weissberg PL: High adenoviral loads stimulate NF kappaB-dependent gene expression in human vascular smooth muscle cells. Gene Ther 1998;5/2:174-180.
40. Maillard L, Van Belle E, Smith RC, Le Roux A, Denefle P: Percutaneous delivery of the gax gene inhibits vessel stenosis in a rabbit model of balloon angioplasty. Cardiovasc Res 1997; 35:536-546.
41. Steg PG, Tahlil O, Aubailly N, Caillaud JM, Dedieu JF, Berthelot K., et al: Reduction of restenosis after angioplasty in an atheromatous rabbit model by suicide gene therapy. Circulation 1997;96:408-411.
42. Jorgensen L, Grothe AG, Groves HM, Kinlough-Rathbone RL: Sequence of cellular responses in rabbit aortas following one and two injuries with a balloon catheter. Br J Exp Pathol 1988;69:473-486.
43. Lefer AM, Ma XL: Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium. Arterioscler Thromb 1993;13: 771-776.
44. Levine GN, Keaney JF Jr, Vita JA: Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. N Engl J Med 1995;332:512-521.
45. Ooboshi H, Rios CD, Chu Y, Christenson SD, Faraci FM, Davidson BL, et al: Augmented adenovirus-mediated gene transfer to atherosclerotic vessels. Arterioscler Thromb Vasc Biol 1997;17:1786-1792.
46. Schneider DB, Fly CA, Dichek DA, Geary RL: Adenoviral gene transfer in arteries of hypercholesterolemic nonhuman primates. Hum Gene Ther 1998;9:815-821.