Vitaxin, a humanized monoclonal antibody to the vitronectin receptor (α(v)β3), reduces neointimal hyperplasia and total vessel area after balloon injury in hypercholesterolemic rabbits

Circulation Research

Volumn 84, Issue 11, 1999, Pages 1268-1276

  Coleman, Kimberly R ^a   Braden, Gregory A ^a   Willingham, Mark C ^a   Sane, David C ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Balloon angioplasty; Hypercholesterolemia; Remodeling; Vitaxin; (v) 3

Indexed keywords

MONOCLONAL ANTIBODY; VITRONECTIN RECEPTOR;

ANIMAL EXPERIMENT; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL MIGRATION; HYPERCHOLESTEROLEMIA; NONHUMAN; PATHOPHYSIOLOGY; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE;

EID: 0033546369     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.84.11.1268     Document Type: Article

References (55)

1. Casscells W. Migration of smooth muscle and endothelial cells: critical events in restenosis. Circulation. 1992;86:723-729.
2. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
3. Schwartz SM, deBlois D, O'Brien EM. The Intima: soil for atherosclerosis and restenosis. Circ Res. 1995;77:445-465.
4. Libby P, Schwartz D, Brogi E, Tanaka H, Clinton S. A cascade model for restenosis: a special case of atherosclerosis progression. Circulation 1992;86(suppl):III-47-III-52.
5. Dufourcq P, Louis H, Moreau C, Daret D, Boisseau MR, Lamaziere J, Bonnet J. Vitronectin expression and interaction with receptors in smooth muscle cells from human atheromatous plaque. Arterioscler Thromb Vasc Biol. 1998;18:168-176.
6. Giachelli CM, Liaw L, Murry CE, Schwartz SM, Almeida M. Osteopontin expression in cardiovascular disease. Ann N Y Acad Sci. 1995;760:109-126.
7. Brown SL, Lundgren CH, Nordt T, Fuji S. Stimulation of migration of human aortic smooth muscle cells by vitronectin: implications for atherosclerosis. Cardiovasc Res. 1994;28:1815-1820.
8. Nelson PR, Yamamura S, Kent KC. Extracellular matrix proteins are potent agonists of human smooth muscle cell migration. J Vasc Surg. 1996;24:25-32.
9. Luscinskas FW, Lawler J. Integrins as dynamic regulators of vascular function. FASEB J. 1994;8:929-938.
10. Hynes RO. Integrin: versatility, modulation, and signaling in cell adhesion. Cell. 1992;69:11-25.
11. Ruoslahti E. Integrins. J Clin Invest. 1991;87:1-5.
12. Choi ET, Engel L, Callow AD, Sun S, Trachtenberg J, Santoro S, Ryan ES. Inhibition of neointimal hyperplasia by blocking αvβ3 integrin with a small peptide antagonist GpenGRGDSPCA. J Vasc Surg. 1994;19: 125-134.
13. Srivatsa SS, Fitzpatrick LA, Tsoa PW, Reilly TM, Holmes DR Jr, Schwartz RS, Mousa SA. Selective αvα3 integrin blockade potently limits neointimal hyperplasia and lumen stenosis following deep coronary arterial stent injury: evidence for the functional importance of integrin αvβ3 and osteopontin expression during neointima formation. Cardiovasc Res. 1997;36:408-428.
14. Matsuno H, Stassen JM, Vermylen J, Deckmyn H. Inhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation. Circulation. 1994;90:2203-2206.
15. Slepian MJ, Massia SP. Preferential antagonism of B3 versus B1 integrin-matrix interactions in vivo limits neointimal hyperplasia following arterial balloon injury. Circulation. 1994;90 (suppl I):I-85. Abstract.
16. Van der Zee R, Passeri J, Barry JJ, Cheresh DA, Isner JM. A neutralizing antibody to the αvβ3 integrin reduces neointimal thickening in a balloon-injured rabbit iliac artery. Circulation. 1996;94 (suppl I):I-257. Abstract.
17. Hoshiga M, Alpers CE, Smith LL, Giachelli CM, Schwartz SM. αvβ3 integrin expression in normal and atherosclerotic artery. Circ Res. 1995; 77:1129-1135.
18. Tam SH, Sassoli PM, Jordan RE, Nakda MT. Abciximab (ReoPro, chimeric 7E3 Fab) demonstrates equivalent affinity and functional blockade of glycoprotein IIb/IIIa and αvβ3 integrins. Circulation. 1998; 98:1085-1091.
19. 3 blockade with percutaneous coronary intervention. EPIC Investigator Group. Evaluation of platelet IIb/IIIa inhibition for prevention of ischemic complication. JAMA. 1997;278:479-484.
20. Cheresh DA, Spiro RC. Biosynthetic and functional properties of a Arg-Gly-Asp directed receptor involved in human melanoma cell attachment to Vitronectin, Fibrinogen, and von Willebrand factor. J Biol Chem. 1987;262:17703-17711.
21. Nachtigal M, Nagpal ML, Greenspan P, Nachtigal SA, Legrand A. Characterization of a continuous smooth muscle cell line derived from rabbit aorta. In Vitro Cell Dev Biol. 1989;25:892-898.
22. Allain CC, Poon LS, Chan CG, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20:470-475.
23. Yebra M, Parry GCN, Stromblad S, Mackman N, Rosenberg S, Mueller BM, Cheresh DA. Requirement of receptor-bound urokinase-type plasminogen activator for integrin αvβ5-directed cell migration. J Biol Chem. 1996;271:29393-29399.
24. Pollman MJ, Hall JL, Mann MJ, Zhang L, Gibbons GH. Inhibition of neointimal cell bcl-x expression induces apoptosis and regression of vascular disease. Nat Med. 1998;4:222-227.
25. Clowes AW, Reidy MA, Clowes MM. Mechanisms of stenosis after arterial injury. Lab Invest. 1983;49:208-215.
26. Williams JK, Armstrong ML, Heistad DD. Endothelial denudation stimulates proliferation of vasa vasorum. J Vasc Med Biol. 1990;2:12-17.
27. Brooks PC, Clark RA, Cheresh DA. Requirement of vascular integrin αvβ3 for angiogenesis. Science. 1994;264:569-571.
28. Coleman KR, Corjay MH, Stoltenborg JK, Diamond SM, Braden GA, Sane DC. Balloon injury of the rabbit aorta induces accumulation of the vitronectin and vitronectin receptor (αvβ3), and hypercholesterolemia augments this effect. J Am Coll Cardiol. 1998;31:1007-104. Abstract.
29. Yue TL, McKenna PJ, Ohlstein EH, Farach-Carson MC, Butler WT, Johanson K, McDevitt P, Feuerstein GZ, Stadel JM. Osteopontin-stimulated vascular smooth muscle migration is mediated by B3 integrin. Exp Cell Res. 1994;214:459-464.
30. Clyman RI, Mauray F, Kramer RH. β1 and β3 integrins have different roles in adhesion and migration of vascular smooth muscle cells on extracellular matrix. Exp Cell Res. 1992;200:272-284.
31. Rogers C, Parikh A, Seifert P, Edelman ER. Endogenous cell seeding: remnant endothelium after stenting enhances vascular repair. Circulation. 1996;94:2909-2914.
32. Van der Zee R, Murohara T, Passen J, Kearney M, Cheresh DA, Isner JM. Reduced intimai thickening following αvβ3 blockade is associated with smooth muscle cell apoptosis. Cell Adhes Commun. 1998;6: 371-379.
33. Ribeiro SM, Schultz-Cherry S, Murphy-Ullrich JE. Heparin-binding vitronectin up-regulates latent TGF-β production by bovine aortic endothelial cells. J Cell Sci. 1995;108(pt 4):1553-1561.
34. 1 is increased in human vascular restenosis lesions. J Clin Invest 1992;90:1582-1592.
35. 1 during repair of arterial injury. J Clin Invest 1991;88:904-910.
36. Eddy AA. Interstitial inflammation and fibrosis in rats with diet-induced hypercholesterolemia. Kidney Int. 1996;50:1139-1149.
37. 2 in aortas of Watanabe rabbits. Cytokine. 1995;7:554-561.
38. Isner JM, Kearney M, Bortman S, Passen J. Apoptosis in human atherosclerosis and restenosis. Circulation. 1995;91:2703-2711.
39. Stromblad S, Becker J, Yebra M, Brooks P, Cheresh D. Suppression of p53 activity and p21 WAF1/CIP1 expression by vascular cell integral αvβ3 during angiogenesis. J Clin Invest. 1996;98:426-433.
40. Brooks PC, Stromblad S, Sanders LC, von Schalscha TL, Aimes R, Stetler- Stevenson WG, Quigley JP, Cheresh DA. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3. Cell. 1996;85:683-693.
41. Matrisian LM. The matrix-degrading metalloproteinases. Bioessays. 1992;14:455-463.
42. Lee RT, Libby P. The unstable atheroma. Arterioscler Thromb Vasc Biol. 1997;17:1859-1867.
43. Mintz GS, Popma JJ, Pichard AD, Kent KM, Sailer LF, Wong SC, Hong MK, Kovach JA, Leon MB. Arterial remodeling after coronary angioplasty: a serial intravascular ultrasound study. Circulation. 1996;94:35-43.
44. Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371-1375.
45. Geary RL, Nikkari ST, Wagner WD, Williams JK, Adams MR, Dean RH. Wound healing: a paradigm for lumen narrowing after arterial reconstruction. J Vasc Surg. 1998;27:96-108.
46. Ashizawa N, Graf K, Do YS, Nunohiro T, Giacheli CM, Meehan WP, Tuan TL, Hsueh WA. Osteopontin is produced by rat cardiac fibroblasts and mediates A(II)-induced DNA synthesis and collagen gel contraction. J Clin Invest. 1996;98:2218-2227.
47. Yee KO, Rooney MM, Giachelli CM, Lord St, Schwartz SM. Role of β1 and β3 integrins in human smooth muscle cell adhesion to and contraction of fibrin clots in vitro. Circ Res. 1998;83:241-251.
48. Mogford JE, Davis GE, Platts SH, Meininger GA. Vascular smooth muscle αvβ3 integrin mediates arteriolar vasodilatation in response to RGD peptides. Circ Res. 1996;79:821-826.
49. Lipke DW, Soltis EE, Fiscus RR, Yang L, Newman PS, Aziz SM. RGD-coataining peptides induce endothelium-dependent and independent vasorelaxations of rat rings. Regul Pept. 1996;63:23-29.
50. Müller JM, Chilian WM, Davis MJ. Integrin signaling transduces shear-stress-dependent vasodilation of coronary arterioles. Circ Res. 1997;80: 320-326.
51. Davis GE. Affinity of integrins for damaged extracellular matrix: αvβ3 binds to denatured collagen type I through RGD sites. Biochem Biophys Res Commun. 1992;182:1025-1031.
52. Montgomery AM, Reisfeld RA, Cheresh DA. Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc Natl Acad Sci U S A. 1994;91:8856-8860.
53. Deitch JS, Williams JK, Adams MR, Fly CA, Herrington DM, Jordan RE, Nakada MT, Jakubowski JA, Geary RL. Effects of β3 blockade (c7E3) on the response to angioplasty and intra-arterial stenting in atherosclerotic non-human primates. Arterioscler Thromb Vasc Biol. 1998;18:1730-1737.
54. Miyamoto S, Akiyama SK, Yamada KM. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science. 1995;267:883-885.
55. Hoffmann R, Mintz GS, Dussaillant GR, Popma JJ, Pichard AD, Satler LF, Kent KM, Griffin J, Leon MB. Patterns and mechanisms of in-stent restenosis: a serial intravascular ultrasound study. Circulation. 1996;94: 1247-1254.