2-arylindole-3-acetamides: FPP-competitive inhibitors of farnesyl protein transferase

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 7, 2001, Pages 865-869

  Trotter, B Wesley ^a   Quigley, Amy G ^a   Lumma, William C ^a   Sisko, John T ^a   Walsh, Eileen S ^a   Hamann, Christian S ^a   Robinson, Ronald G ^a   Bhimnathwala, Hema ^a   Kolodin, D Garrett ^a   Zheng, Wei ^a   Buser, Carolyn A ^a   Huber, Hans E ^a   Lobell, Robert B ^a   Kohl, Nancy E ^a   Williams, Theresa M ^a   Graham, Samuel L ^a   Dinsmore, Christopher J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; FARNESYL DIPHOSPHATE; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; DRUG IDENTIFICATION; ENZYME INHIBITION; NONHUMAN; ONCOGENE K RAS; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; CARRIER PROTEINS; ENZYME INHIBITORS; HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; HUMANS; INDOLEACETIC ACIDS; PROTEIN ISOPRENYLATION; RAS PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035832096     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00061-0     Document Type: Article

References (31)