Cortical spreading depression produces increased cGMP levels in cortex and brain stem that is inhibited by tonabersat (SB-220453) but not sumatriptan

Brain Research

Volumn 891, Issue 1-2, 2001, Pages 69-77

  Read, Simon J ^a   Hirst, Warren D ^a   Upton, Neil ^a   Parsons, Andrew A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Cortical spreading depression; Migraine; Nitric oxide; Sumatripan; Tonabersat

Indexed keywords

ANTIMIGRAINE AGENT; CYCLIC GMP; NITRIC OXIDE; SUMATRIPTAN; TONABERSAT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; BRAIN STEM; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOREACTIVITY; MEMBRANE DEPOLARIZATION; MIGRAINE; NEUROTRANSMITTER RELEASE; NONHUMAN; ONCOGENE C FOS; PARIETAL LOBE; PRIORITY JOURNAL; RAT; SPREADING CORTICAL DEPRESSION; STEREOSPECIFICITY;

ANALGESICS; ANIMALS; BENZAMIDES; BENZOPYRANS; BRAIN STEM; CEREBRAL CORTEX; CYCLIC GMP; MALE; MIGRAINE DISORDERS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SPREADING CORTICAL DEPRESSION; SUMATRIPTAN; VASOCONSTRICTOR AGENTS;

EID: 0035830717     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)03191-7     Document Type: Article

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