Enhanced nitric oxide release during cortical spreading depression following infusion of glyceryl trinitrate in the anaesthetized cat

Cephalalgia

Volumn 17, Issue 3, 1997, Pages 159-165

  Read, S J ^a   Smith, M I ^a   Hunter, A J ^a   Parsons, A A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

cortical spreading depression; glyceryl trinitrate; migraine; nitric oxide

Indexed keywords

GLYCERYL TRINITRATE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; LASER DOPPLER FLOWMETRY; MALE; MICROELECTRODE; MIGRAINE; NONHUMAN; PATHOGENESIS; SPREADING CORTICAL DEPRESSION;

ANESTHESIA; ANIMALS; CATS; INJECTIONS, INTRAVENOUS; MALE; NITRIC OXIDE; NITROGLYCERIN; SPREADING CORTICAL DEPRESSION;

EID: 0030922462     PISSN: 03331024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-2982.1997.1703159.x     Document Type: Article

References (26)

1. Feelisch M, Brands F, Keim M. Human endothelial cells bioactivate organic nitrates to nitric oxide: implications for the reinforcement of endothelial defence mechanisms. Eur J Clin Invest 1995;25:737-45
2. Iversen HK, Olesen J, Tfelt-Hansen P. Intravenous nitroglycerin as an experimental model of vascular headache. Pain 1989;38:17-24
3. Dahl A, Russell D, Nyberg-Hansen R, Rootwelt K. Cluster headache: transcranial Doppler ultrasound and rCBF studies. Cephalalgia 1990;10:87-94
4. Thomsen LL, Iversen HK, Brinck TA, Olesen J. Arterial supersensitivity to nitric oxide (nitroglycerin) in migraine sufferers. Cephalalgia 1993;13:395-9
5. Thomsen LL, Kruuse C, Iversen HK, Olesen J. A nitric oxide donor (nitroglycerin) triggers genuine migraine attacks. Eur J Neurol 1994;1:73-80
6. Lassen LH, Thomsen LL, Kruuse C, Iversen HK, Olesen J. Histamine-1 receptor blockade does not prevent nitroglycerin-induced migraine. Support for the NO-hypothesis of migraine. Eur J Clin Pharmacol 1996;49:335-9
7. Iversen HK, Nielsen TH, Garre K, Tfelt-Hansen P, Olesen J. Dose-dependent headache response and dilatation of limb and extracranial arteries after three doses of 5-isosorbide-mononitrate. Eur J Clin Pharmacol 1992;42:31-5
8. Wei EP, Moskowitz MA, Baccalini P, Kontos HA. Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles. Circ Res 1992;70:1313-9
9. Olesen J, Iversen HK, Thomsen LL. Nitric oxide supersensitivity: a possible molecular mechanism of migraine pain. Neuroreport 1993;4:1027-30
10. Olesen J, Thomsen LL, Iversen HK. Nitric oxide is a key molecule in migraine and other vascular headaches. TIPS 1994;15:149-53
11. Olesen J, Larsen B, Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol 1981;9:344-52
12. Lauritzen M. Pathophysiology of the migraine aura. The spreading depression theory. Brain 1994;117:199-210
13. Olesen J. Cerebral and extracranial circulatory disturbances in migraine: pathophysiological implications. Cerebrovasc Brain Metab Rev 1991;3:1-28
14. Leao AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol 1944;7:359-90
15. Avoli M, Drapeau C, Louvel J, Pumain R, Olivier A, Villemure J-G. Epileptiform activity induced by low extracellular magnesium in the human cortex maintained in vitro. Ann Neurol 1991;30:589-96
16. Mayevsky A, Doron A, Manor T, Meilin S, Salame K, Ouaknine GE. Repetitive cortical spreading depression cycle development in the human brain: a multiparametric monitoring approach. J Cereb Blood Flow Metab 1995;15 Suppl 1:S34
17. Goadsby PJ, Kaube H, Hoskin KL. Nitric oxide synthesis couples cerebral blood flow and metabolism. Brain Res 1992; 595:167-70
18. Read SJ, Smith MI, Hunter AJ, Parsons AA. Measurement of nitric oxide release using a selective microelectrode following repeated waves of cortical spreading depression. Br J Pharmacol 1996;118:79P
19. Persson MG, Agvald P, Gustafsson LE. Detection of nitric oxide in exhaled air during administration of nitroglycerin in vivo. Br J Pharmacol 1994;111:825-8
20. Sorkin EM, Brogden RN, Romankiewicz JA. Intravenous glyceryl trinitrate (nitroglycerin). A review of its pharmacological properties and therapeutic efficacy. Drugs 1984;27:45-80
21. Feelisch M, Keim M. Biotransformation of organic nitrates to nitric oxide by cultured vascular smooth muscle and endothelial cells. Biochem Biophys Res Commun 1991;180:286-93
22. Philbert MA, Beiswanger CM, Manson MM, Green JA, Novak RF, Primiano T, Reuhl KR, Lowndes HE. Glutathione S-transferases and gamma-glutamyl transpeptidase in the rat nervous systems: a basis for differential susceptibility to neurotoxicants. Neurotoxicology 1995;16:349-62
23. Awasthi YC, Sharma R, Singhal SS. Human Glutathione S-transferases. Int J Biochem 1994;26:295-308
24. Warner M, Stromstedt M, Wyss A, Gustafsson JA. Regulation of cytochrome P450 in the central nervous system. J Steroid Biochem Mol Biol 1993;47:191-4
25. Marks GS, McLaughlin BE, Nakatsu K, Brein JF. Biotransformation of glyceryl trinitrate by rat brain homogenate. Can J Physiol Pharmacol 1992;70:935-7
26. Wahl M, Schilling L, Parsons AA, Kaumann A. Involvement of calcitonin gene-related peptide (CGRP) and nitric oxide (NO) in the pial artery dilatation elicited by cortical spreading depression. Brain Res 1994;637:204-10