Group I metabotropic glutamate receptors prevent endothelial programmed cell death independent from MAP kinase p38 activation in rat

Neuroscience Letters

Volumn 298, Issue 3, 2001, Pages 207-211

  Lin, Shi Hua ^a   Maiese, Kenneth ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; DNA degradation; Metabotropic glutamate receptors; Nitric oxide; Phosphatidylserine residues; Primary endothelial cell culture

Indexed keywords

DNA FRAGMENT; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD VESSEL INJURY; BRAIN ASYMMETRY; CONTROLLED STUDY; DNA DEGRADATION; DRUG ACTIVATION; DRUG RECEPTOR BINDING; ENDOTHELIUM CELL; ISCHEMIA; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; DNA FRAGMENTATION; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; IN SITU NICK-END LABELING; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLSERINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0035830715     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(00)01766-3     Document Type: Article

References (15)

1. Apoptotic vascular endothelial cells become procoagulant
2. Group I metabotropic glutamate receptors: Implications for brain diseases
3. Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis
4. Immunochemical localization of the metabotropic glutamate receptors in the rat heart
5. An inhibitor of p38 and JNK MAP kinases prevents activation of caspase and apoptosis of cultured cerebellar granule neurons
6. Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-D-aspartate-induced necrosis in mouse cortical neurons
7. Expression of glutamate receptors on cultured cerebral endothelial cells
8. Neuroprotection by peptide growth factors against anoxia and nitric oxide toxicity requires modulation of protein kinase C
9. Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons
10. Membrane asymmetry and DNA degradation: Functionally distinct determinants of neuronal programmed cell death
11. Increased surface phosphatidylserine is an early marker of neuronal apoptosis
12. Recognition and phagocytosis of cells undergoing apoptosis
13. Protective effect of group I metabotropic glutamate receptor activation against hypoxic/hypoglycemic injury in rat hippocampal slices: Timing and involvement of protein kinase C
14. Nitric oxide induces and inhibits apoptosis through different pathways
15. Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular pH