Group I metabotropic receptors down-regulate nitric oxide induced caspase-3 activity in rat hippocampal neurons

Neuroscience Letters

Volumn 264, Issue 1-3, 1999, Pages 17-20

  Maiese, Kenneth ^a   Vincent, Andrea M ^a  

^a Division of Cellular and Molecular Cerebral Ischemia   (United States)

Author keywords

Apoptosis; Caspase 3; Cysteine proteases; Metabotropic glutamate receptors; Neurodegeneration; Nitric oxide; Primary hippocampal neuronal culture

Indexed keywords

CASPASE 3; METABOTROPIC RECEPTOR; NITRIC OXIDE;

ANIMAL CELL; ARTICLE; BRAIN DEGENERATION; ENZYME ACTIVITY; HIPPOCAMPUS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; ENZYME INDUCTION; HIPPOCAMPUS; NEURONS; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0033515795     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00199-8     Document Type: Article

References (14)

1. Alnemri E.S., Livingston D.J., Nicholson D.W., Salvesen G., Thornberry N.A., Wong W.W., Yuan J. Human ICE/CED-3 protease nomenclature. Cell. 87:1996;171.
2. Amos B.J., Mathie A., Richards C.D. Activation of group I metabotropic glutamate receptors elicits pH changes in cultured rat cortical glia and neurons. Neuroscience. 86:1998;1109-1120.
3. Anneser J.M., Horstmann S., Weydt P., Borasio G.D. Activation of metabotropic glutamate receptors delays apoptosis of chick embryonic motor neurons in vitro. NeuroReport. 9:(9):1998;2039-2043.
4. Chu Z., Hablitz J.J. Activation of group I mGluRs increases spontaneous IPSC frequency in rat frontal cortex. J. Neurophysiol. 80:1998;621-627.
5. Maiese K. Cellular mechanisms of neuronal protection by metabotropic glutamate receptors. Robertson J.T., Nowak T.S. Frontiers in Cerebrovascular Disease: Mechanisms, Diagnosis, and Treatment. 1998;281-297 Futura, Armonk, NY.
6. Maiese K., Ahmad I., TenBroeke M., Gallant J. Metabotropic glutamate receptor subtypes independently modulate neuronal intracellular calcium. J. Neurosci. Res. 55:1998;472-485.
7. Maiese K., Boniece I., DeMeo D., Wagner J.A. Peptide growth factors protect against ischemia in culture by preventing nitric oxide toxicity. J. Neurosci. 13:1993;3034-3040.
8. Maiese K., Boniece I.R., Skurat K., Wagner J.A. Protein kinases modulate the sensitivity of hippocampal neurons to nitric oxide toxicity and anoxia. J. Neurosci. Res. 36:1993;77-87.
9. Moroni F., Lombardi G., Thomsen C., Leonardi P., Attucci S., Peruginelli F., Torregrossa S.A., Pellegrini-Giampietro D.E., Luneia R., Pellicciari R. Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist, J. Pharmacol. Exp. Ther. 281:1997;721-729.
10. Nishio E., Watanabe Y. NO induced apoptosis accompanying the change of oncoprotein expression. Life Sci. 62:1998;239-245.
11. Palluy O., Rigaud M. Nitric oxide induces cultured cortical neuron apoptosis. Neurosci. Lett. 208:1996;1-4.
12. Vincent A.M., Maiese K. Nitric oxide induction of neuronal endonuclease activity in programmed cell death. Exp. Cell Res. 246:1999;240-300.
13. Vincent A.M., Mohammad Y., Ahmad I., Greenberg R., Maiese K. Metabotropic glutamate receptors prevent nitric oxide induced programmed cell death. J. Neurosci. Res. 50:1997;549-564.
14. Vincent A.M., TenBroeke M., Maiese K. Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular pH. Exp. Neurol. 155:1999;79-94.