Research opportunities and advances in lung disease

JAMA

Volumn 285, Issue 5, 2001, Pages 612-618

  Crystal, Ronald G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHRONIC LUNG DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; LUNG ALVEOLUS SURFACE TENSION; LUNG DISEASE; LUNG GAS EXCHANGE; MEDICAL RESEARCH; PATHOGENESIS; PRIORITY JOURNAL;

EID: 0035819476     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.285.5.612     Document Type: Article

References (69)

1. Disease statistics
2. The acute respiratory distress syndrome
3. Pulmonary surfactant and respiratory distress syndrome in the newborn infant
4. Pulmonary surfactant therapy
5. Alpha 1-antitrypsin deficiency, emphysema, and liver disease: Genetic basis and strategies for therapy
6. Identification of the cystic fibrosis gene: Genetic analysis
7. Inherited susceptibility of the lung to proteolytic injury
8. Identification of a second mutation in the protein-coding sequence of the z type alpha 1-antitrypsin gene
9. Identification of the cystic fibrosis gene: Cloning and characterization of complementary DNA
10. Identification of the cystic fibrosis gene: Chromosome walking and jumping
11. Cystic fibrosis
12. Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema
13. Pulmonary embolism
14. Hereditary thrombophilia and venous thromboembolism
15. The genetics of asthma
16. Interstitial lung disease
17. Non-neoplastic disorders due to metallic, chemical and physical agents
18. The role of cockroach allergy and exposure to cockroach allergen in causing morbidity among inner-city children with asthma
19. Tools of molecular biology used to study the lung
20. Bronchoalveolar lavage
21. Obstructive sleep apnea
22. Sensitivity and specificity of helical computed tomography in the diagnosis of pulmonary embolism: A systematic review
23. Spiral CT angiography of the pulmonary circulation
24. Nuclear medicine techniques and applications
25. Physiological reviews: Physiology of cystic fibrosis
26. Antiproteases and lung defense
27. Proteases and lung injury
28. Pulmonary responses to chronic inorganic dust exposure
29. Alpha 1-antitrypsin: The key to emphysema
30. Community outbreaks of asthma associated with inhalation of soybean dust
31. Hypersensitivity pneumonitis
32. Pneumoconioses
33. Biology of pulmonary fibrosis
34. Medical progress: Chronic obstructive pulmonary disease
35. Cigarette smoking induces functional antiprotease deficiency in the lower respiratory tract of humans
36. Respiratory cell culture
37. Nature genetics: Going global
38. Transgenic mice for study of pulmonary disease
39. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
40. Familial idiopathic pulmonary fibrosis: Evidence of lung inflammation in unaffected family members
41. Human gene therapy
42. Transfer of genes to humans: Early lessons and obstacles to success
43. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis
44. Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo
45. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium
46. Clonal gene therapy: Transplanted mouse fibroblast clones express human alpha 1-antitrypsin gene in vivo
47. Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors
48. DNA vaccines: Immunology, application, and optimization
49. Dendritic cells modified to express CD40 ligand and pulsed with Pseudomonas elicit CD4+ T cell-independent protective humoral immunity against bronchopulmonary infection with Pseudomonas
50. Anti-IgE antibody therapy for asthma
51. Treatment of allergic asthma with monoclonal anti-IgE antibody
52. Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency
53. Anti-neutrophil-elastase defenses of the lower respiratory tract in alpha 1-antitrypsin deficiency directly augmented with an aerosol of alpha 1-antitrypsin
54. Strategies for aerosol therapy of alpha 1-antitrypsin deficiency by the aerosol route
55. Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA
56. Gene therapy for lung disease
57. Molecular mechanisms controlling lung morphogenesis
58. A lungful of transcription factors
59. Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus
60. Lung transplantation