BLyS binds to B cells with high affinity and induces activation of the transcription factors NF-κB and ELF-1

Cytokine

Volumn 13, Issue 1, 2001, Pages 25-31

  Kanakaraj, Palanisamy ^a   Migone, Thi Sau ^a   Nardelli, Bernardetta ^a   Ullrich, Stephen ^a   Li, Yuling ^a   Olsen, Henrik S ^a   Salcedo, Theodora W ^a   Kaufman, Thomas ^a   Cochrane, Erika ^a   Gan, Yuxiang ^a   Hilbert, David M ^a   Giri, Judith ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

B lymphocyte stimulator (BLyS); Binding; Signaling; Transcription factors; Tumour necrosis factor (TNF)

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; IODINE 125; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 1; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BINDING SITE; BONE MARROW CELL; CELL PROLIFERATION; DISSOCIATION CONSTANT; GEL FILTRATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; ISOTOPE LABELING; LIGHT SCATTERING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; RECEPTOR BINDING; SCATCHARD PLOT; TONSIL CELL;

EID: 0035819243     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2000.0793     Document Type: Article

References (33)

1. TALL-1 is a novel member of the TNF family that is downregulated by mitogens
2. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth
3. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-kappaB, and c-Jun NH2-terminal kinase
4. Characterization of a new member of the TNF family expressed on antigen presenting cells
5. TACI and BCMA are receptors for a TNF homologue implicated in B-cell immune autoimmune disease
6. BLyS: A member of the tumor necrosis factor family and B lymphocyte stimulator
7. Identification of a ligand for the death-domain-containing receptor Apo3
8. Identification and characterization of a new member of the TNF family that induces apoptosis
9. LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator
10. TRANCE (tumor necrosis factor (TNF)-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
11. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
12. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations
13. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice
14. Tumor necrosis factor receptor superfamily and their ligands
15. Death receptors: Signaling and modulation
16. Tumor necrosis factor superfamily members in the immune system
17. TNF receptor associated factors in cytokine signaling
18. 2A crystal structure of an extracellular fragment of human CD40 ligand
19. The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding
20. Structure of tumor necrosis factor
21. Crystal structure of the soluble 55kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation
22. Affinity and kinetics of the interaction between solublew trimeric OX40 ligand, a member of the tumor necrosis factor superfamily, and its receptor OX40 on activated T cells
23. Binding and crosslinking of 125I-labeled recombinant human tumor necrosis factor to cell surface receptors
24. Characterization and affinity crosslinking of receptors for tumor necrosis factor on human cells
25. Biochemical properties of the 75-kDa tumor necrosis factor receptor. Characterization of ligand binding, internalization and receptor phosphorylation
26. Iodination of chemokines for use in receptor binding analysis
27. Comparative molecular modelling of the Fas-ligand and other memebers of the TNF family
28. Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila
29. Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk
30. Signaling from the IL-2 receptor to the nucleus
31. NF-AT activation by a CAML-interacting member of the tumor necrosis superfamily
32. The characterization of murine BCMA gene defines it is anew memebr of the tumor necrosis factor receptor superfamily