Tolerance to the organic nitrates new ideas, new mechanisms, continued mystery

Circulation

Volumn 104, Issue 19, 2001, Pages 2263-2265

  Parker, John D ^a   Gori, Tommaso ^a  

^a MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Editorials; Nitric oxide; Nitroglycerin; Pharmacology

Indexed keywords

ACETYLCYSTEINE; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; GLYCERYL TRINITRATE; ISOSORBIDE 5 NITRATE; NITRATE; NITRIC OXIDE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE INHIBITOR;

ANIMAL MODEL; BIOAVAILABILITY; CARDIOVASCULAR DISEASE; DRUG MECHANISM; EDITORIAL; ENZYME INHIBITION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SECOND MESSENGER; VASCULAR ENDOTHELIUM;

EID: 0035818534     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/circ.104.19.2263     Document Type: Editorial

References (21)

1. Mechanism of tolerance development to organic nitrates
2. Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels
3. Nitroglycerin tolerance in human vessels: Evidence for impaired nitroglycerin bioconversion
4. Nitrate therapy for stable angina pectoris
5. Evidence for enhanced vascular superoxide anion production in nitrate tolerance: A novel mechanism underlying tolerance and cross-tolerance
6. Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state
7. Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans
8. Long-term nitroglycerin treatment is associated with supersensitivity to vasoconstrictors in men with stable coronary artery disease: Prevention by concomitant treatment with captopril
9. Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase: A new action for an old drug
10. Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS) gene expression, NOS-mediated superoxide production, and vascular NO bioavailability
11. Evidence for a causal role of the renin-angiotensin system in nitrate tolerance
12. Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance
13. Folic acid prevents nitroglycerin- induced nitric oxide synthase dysfunction and nitrate tolerance: A human in vivo study
14. Upregulation of phosphodiesterase 1A1 gene expression is associated with the development of nitrate tolerance
15. Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivo
16. Reversal of nitroglycerin tolerance in vitro by the cGMP-phosphodiesterase inhibitor zaprinast
17. Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina
18. Mechanisms for the pharmacologic interaction of organic nitrates with thiols: Existence of an extracellular pathway for the reversal of nitrate vascular tolerance by N-acetylcysteine
19. Lack of cross-tolerance to short-term linsidomine in forearm resistance vessels and dorsal hand veins in subjects with nitroglycerin tolerance
20. Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP- dependent protein kinase and their downstream target vasodilator- stimulated phosphoprotein in aorta
21. What causes tolerance to nitroglycerin? The 100-year-old mystery continues