Endothelin-receptor antagonists in pulmonary hypertension

Lancet

Volumn 358, Issue 9288, 2001, Pages 1113-1114

  Dupuis, Jocelyn ^a  

^a MONTREAL HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BOSENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; NITRIC OXIDE; PROSTACYCLIN;

CLINICAL TRIAL; DOSE RESPONSE; DRUG CLEARANCE; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; DRUG SCREENING; DRUG WITHDRAWAL; HEMODYNAMICS; HUMAN; LONG TERM CARE; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PULMONARY HYPERTENSION; RECEPTOR BLOCKING; SCLERODERMA; TISSUE DISTRIBUTION; TREATMENT OUTCOME; VASOCONSTRICTION;

EID: 0035818267     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(01)06298-5     Document Type: Note

References (10)

1. Human pulmonary circulation is an important site for both clearance and production of endothelin-1
2. Blocking of the endothelin system: The development of receptor antagonists
3. Effectiveness of a nonselective ET(A/B) and a selective ET(A) antagonist in rats with monocrotaline-induced pulmonary hypertension
4. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor
5. ET(B) receptor and nitric oxide synthase blockade induce BQ-123-sensitive pressor effects in the rabbit
6. Short-term oral endothelin-receptor antagonist therapy in conventionally treated patients with symptomatic severe chronic heart failure
7. Role of endothelin-1 in beagles with dehydromonocrotaline-induced pulmonary hypertension
8. Effects of separate and combined ETA and ETB blockade on ET-1-induced constriction in perfused rat lungs
9. Importance of local production of endothelin-1 and of the ET(B) receptor in the regulation of pulmonary vascular tone
10. Hemodynamic effects of Bosentan, an endothelin receptor antagonist, in patients with pulmonary hypertension