RTI-76, an irreversible inhibitor of dopamine transporter binding, increases locomotor activity in the rat at high doses

Brain Research

Volumn 897, Issue 1-2, 2001, Pages 157-163

  Kimmel, Heather L ^a   Carroll, F Ivy ^b   Kuhar, Michael J ^a  

^a EMORY UNIVERSITY   (United States)

^b RTI INTERNATIONAL   (United States)

Author keywords

Binding; Dopamine transporter; GBR12935; Locomotor activity; Rat; RTI 76

Indexed keywords

1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLALLYL)PIPERAZINE; 1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; 3BETA (4 CHLOROPHENYL)TROPAN 2BETA CARBOXYLIC ACID 4 ISOTHIOCYANATOPHENETHYL ESTER; CARRIER PROTEIN; DOPAMINE TRANSPORTER; ESTER DERIVATIVE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG MEGADOSE; HALF LIFE TIME; LOCOMOTION; MALE; MOTOR ACTIVITY; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

ANIMALS; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CARRIER PROTEINS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAVENTRICULAR; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MOTOR ACTIVITY; NERVE TISSUE PROTEINS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; TRITIUM; TROPANES;

EID: 0035815483     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02118-7     Document Type: Article

References (27)

1. Probes for the cocaine receptor. Potentially irreversible ligands for the dopamine transporter
2. Behavioral effects of novel cocaine analogs: A comparison with in vivo receptor binding potency
3. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
4. Dopamine receptors and dopamine transporter in brain function and addictive behaviors: Insights from targeted mouse mutants
5. RTI-113 administration reduces cocaine self-administration at high occupancy of dopamine transporter
6. Highly potent cocaine analogs cause long-lasting increases in locomotor activity
7. Recovery of dopamine transporter binding and function after intrastriatal administration of the irreversible inhibitor RTI-76 {3β-(3p-chlorophenyl)tropan-2β-carboxylic acid p-isothiocyanatophenylethyl ester hydrochloride}
8. Functional hyperdopaminergia in dopamine transporter knock-out mice
9. Comparison of the effects of prototypical behavioral stimulants on locomotor activity and rotational behavior in rats
10. Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
11. Comparison of a novel tropane analog of cocaine, 2β-propanoyl-3β-(4-tolyl) tropane with cocaine HCl in rats: Nucleus accumbens extracellular dopamine concentration and motor activity
12. Dopamine transporter synthesis and degradation in rat striatum and nucleus accumbens using RTI-76
13. Cellular and molecular mechanisms of drug dependence
14. Differential effect of amphetamine and dopamine uptake blockers (cocaine, nomifensine) on caudate and accumbens dialysate dopamine and 3-methoxytyramine
15. Amphetamine, cocaine, and fencamfamine: Relationship between locomotor and stereotypy response profiles and caudate and accumbens dopamine dynamics
16. The Otto Krayer Award Lecture: Neurotransmitters as drug targets: Recent research with a focus on the dopamine transporter
17. The dopamine hypothesis of the reinforcing properties of cocaine
18. The dopamine transporter: Comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens
19. Turnover of rat dopamine transporter protein in rDAT-LLC-PK1 cells
20. Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity
21. Cocaine receptors on dopamine transporters are related to self-administration of cocaine
22. The dopamine hypothesis of reward: Past and current status
23. Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on scheduled-controlled behavior
24. Serotonin transporter production and degradation: Studies with RTI-76
25. Relationship between subjective effects of cocaine and dopamine transporter occupancy
26. Comparison between dopamine transporter affinity and self-administration potency of local anesthetics in rhesus monkeys
27. Characterization of dopamine transporter and locomotor effects of cocaine, GBR 12909, epidepride, and SCH 23390 in C57BL and DBA mice