Inhibition of the myeloperoxidase chlorinating activity by non-steroidal anti-inflammatory drugs investigated with a human recombinant enzyme

European Journal of Pharmacology

Volumn 417, Issue 1-2, 2001, Pages 37-43

  Nève, Jean ^a,c   Parij, Nathalie ^a   Moguilevsky, Nicole ^b  

^a PHARMACEUTICAL INSTITUTE   (Belgium)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Compound II; Inflammation; Myeloperoxidase; NSAID (non steroidal anti inflammatory drug); Reactive oxygen species; Recombinant human enzyme

Indexed keywords

CHLORIDE ION; HYDROCHLORIC ACID; HYDROGEN PEROXIDE; MYELOPEROXIDASE; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT ENZYME; TAURINE;

ARTICLE; CHLORINATION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; INFLAMMATION; PRIORITY JOURNAL; SCAVENGING SYSTEM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHLORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPOCHLOROUS ACID; PEROXIDASE; RECOMBINANT PROTEINS; TAURINE;

EID: 0035815303     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00895-0     Document Type: Article

References (31)

1. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase
2. A method for screening hypochlorous acid scavengers by inhibition of the oxidation of 5-thio-2-nitrobenzoic acid. Application to antiastmatic drugs
3. 2.3 A resolution X-ray crystal structure of the bisubstrate analogue inhibitor salicylhydroxamic acid bound to human myeloperoxidase: A model for a prereaction complex with hydrogen peroxide
4. 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinase
5. Towards a molecular understanding of arthritis
6. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups
7. Studies on the chlorinating activity of Myeloperoxidase
8. Production of active oxygen species by isolated human chondrocytes
9. Involvement of leukocyte peroxidase in the metabolism of tenoxicam
10. 2 produces novel products
11. Spectral and enzymatic properties of human recombinant myeloperoxidase: Comparison with the mature enzyme
12. Hydroxyl radicals generation by rheumatoid blood and knee joint synovial fluid
13. Superoxide modulates the activity of myeloperoxidase and optimizes the production of hypochlorous acid
14. Superoxide enhances hypochlorous acid production by stimulated human neutrophils
15. Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs
16. Superoxide is an antagonist of anti-inflammatory drugs that inhibit hypochlorous acid production by myeloperoxidase
17. The sulfonium ion linkage in myeloperoxidase: Direct spectroscopic detection by isotopic labelling and effect of mutation
18. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assesment of inflammation in rat and hamster models
19. Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase and hypochlorous acid
20. Structural and biological properties of human recombinant myeloperoxidase produced by Chinese hamster ovary cell lines
21. Non-steroidal anti-inflammatory drugs interact with horseradish peroxidase in an in vitro assay system for hydrogen peroxide scavenging
22. Effects of non-steroidal anti-inflammatory drugs on the luminol and lucigenin amplified chemiluminescence of human neutrophils
23. Release of oxygen radicals by articular chondrocytes: A study of luminol-dependant chemiluminescence and hydrogen peroxide secretion
24. Activation of latent human neutrophil collagenase by reactive oxygen species and serine protease
25. - system of neutrophils by indomethacin and other non-steroidal antiinflammatory drugs
26. Role of oxygen radicals and IL-6 in IL-1-dependent cartilage matrix degradation
27. The generation of utilization of chlorinated oxidants by human neutrophils
28. Inhibitory effects of non-steroidal anti-inflammatory drugs on human myeloperoxidase
29. Biologically significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by some anti-inflammatory drugs
30. Tissue destruction by neutrophils
31. Interaction of myeloperoxidase with diclofenac. Inhibition of the chlorinating activity of myeloperoxidase by diclofenac and oxidation of diclofenac to dihydroxyazobenzene by myeloperoxidase