Dimeric DNA quadruplex containing major groove-aligned A·T·A·T and G·C·G·C tetrads stabilized by inter-subunit Watson-Crick A·T and G·C pairs

Journal of Molecular Biology

Volumn 312, Issue 5, 2001, Pages 1073-1088

  Zhang, Na ^a   Gorin, Andrey ^a   Majumdar, Ananya ^a   Kettani, Abdelali ^a   Chernichenko, Natalya ^a   Skripkin, Eugene ^a   Patel, Dinshaw J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

A T A T and G C G C tetrads; Dimeric DNA quadruplex; Hydrogen bond alignments; Inter subunit Watson Crick pairs

Indexed keywords

DIMER; DNA; SODIUM CHLORIDE;

ARTICLE; AT RICH SEQUENCE; GC RICH SEQUENCE; HYDROGEN BOND; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL;

EID: 0035812604     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5002     Document Type: Article

References (39)

1. G-quartet structures in telomeric DNA
2. Telomere structure and function
3. 1H NMR spectroscopy of DNA triplexes and quadruplexes
4. Structures of guanine-rich and cytosine-rich quadruplexes formed in vitro by telomeric, centromeric and triplet repeat disease sequences
5. Functional and dysfunctional roles of quadruplex DNA in cells
6. The structure of telomeric DNA: DNA quadruplex formation
7. Solution structure of a DNA quadruplex containing the fragile X syndrome triplet repeat
8. Self-association of a DNA loop creates a quadruplex crystal structure of d(GCATGCT) at 1.8 Å resolution
9. Dimeric solution structure of two cyclic octamers. Four-stranded DNA structures stabilized by A·T·A·T and G·C·G·C tetrads
10. + cation stabilized DNA quadruplex containing G·G·G·G and G·C·G·C tetrads formed by G-G-G-C repeats observed in adeno-associated viral DNA
11. + cation dependent conformational switch within a loop spanning segment of a DNA quadruplex containing G-G-G-C repeats
12. 2··N hydrogen bonds in a sheared G·A mismatches via remote, nonexchangeable protons
13. The bi-loop, a new general four-stranded DNA motif
14. Triad-DNA: A model for trinucleotide repeats
15. Bombyx mori single repeat telomeric DNA sequences forms a G-quadruplex capped by base triads
16. A two-stranded template-based approach to G·(C-A) triad formation: Designing novel structural elements into an existing DNA framework
17. A diamond-shaped zipper-like DNA architecture containing triads sandwiched between mismatches and tetrads
18. A double chain reversal loop and two diagonal loops define the architecture of a unimolecular DNA quadruplex containing a pair of stacked G(syn)·G(syn)·G(anti)·G(anti) tetrads flanked by a G·(T-T) triad and a T·T·T triple
19. A dimeric DNA interface stabilized by A·(G·G·G·G)·A hexads and coordinated monovalent cations
20. 13C-J couplings and the through-bond correlation of imino and non-exchangeable protons in unlabeled DNA
21. NN couplings
22. NMR scalar couplings across Watson-Crick base-pair hydrogen bonds in DNA observed by transverse relaxation-optimized spectroscopy
23. 15N nuclei with widely separaterd chemical shifts
24. Observation of internucleotide N-H··N hydrogen bonds in the absence of directly detectable protons
25. Detection of N-H··N hydrogen bonding in RNA via scalar couplings in the absence of observable imino proton resonances
26. Interlocked mismatch-aligned arrowhead DNA motifs
27. Thrombin-binding DNA aptamer forms a unimolecular quadruplex structure in solution
28. The tertiary structure of a DNA aptamer which binds to and inhibits thrombin determines activity
29. Hairpins loops consisting of single adenine residues closed by a sheared A·A and G·G pairs formed by the DNA triplets AAA and GAG: Solution structure of the d(GTACAAAGTAC)
30. Most compact hairpin turn structure exerted by a short DNA fragment d(GCGAAGC) in solution: An extra-ordinarily stable structure resistant to nucleases and heat
31. Models of specifically paired like (homologous) nucleic acid structures
32. Nicked-free formation of reciprocal heteroduplexes: A simple solution to the topological problem
33. Unique structures formed by pyrimidine·purine DNA which may be four-stranded
34. Association of poly(CA)·poly(TG) DNA fragments into four-stranded complexes bound by HMG1 and 2
35. Modeling a strand exchange tetraplex conformation
36. 15N-labeled DNA oligonucleotides
37. Calculation of protein structures with ambiguous distance restraints. Automated assignment of ambiguous NOE cross-peaks and disulfide connectivities
38. Relaxation matrix alignment of the solution structure of squash trypsin inhibitor