Oral absorption of cephalosporins is quantitatively predicted from in vitro uptake into intestinal brush border membrane vesicles

International Journal of Pharmaceutics

Volumn 220, Issue 1-2, 2001, Pages 119-128

  Kohda Shimizu, Rikako ^a   Li, Yin Hua ^a   Shitara, Yoshihisa ^a   Ito, Kiyomi ^a   Tsuda, Yasuyuki ^a   Yamada, Hideo ^b   Itoh, Tomoo ^a  

^a KITASATO UNIVERSITY   (Japan)

^b MUSASHINO UNIVERSITY   (Japan)

Author keywords

Absorption; Cephalosporin antibiotics; Oligopeptide transoporter; PepT1; Prediction; Rat intestinal BBMV

Indexed keywords

CARRIER PROTEIN; CEFACLOR; CEFALEXIN; CEFAZOLIN; CEFIXIME; CEFOTIAM; CEFRADINE; CEFTIBUTEN; CEPHALOSPORIN; PROTON;

ARTICLE; BRUSH BORDER VESICLE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG MIXTURE; DRUG UPTAKE; IN VITRO STUDY; INTESTINE BRUSH BORDER MEMBRANE; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PREDICTION; PRIORITY JOURNAL;

ABSORPTION; ANIMALS; CARRIER PROTEINS; CEPHALOSPORINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MICROVILLI; PREDICTIVE VALUE OF TESTS; RATS; SYMPORTERS; TEMPERATURE;

EID: 0035806305     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00664-0     Document Type: Article

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