In vitro evidence for homologous recombinational repair in resistance to melphalan

Journal of the National Cancer Institute

Volumn 93, Issue 19, 2001, Pages 1473-1478

  Wang, Zhi Min ^a   Chen, Zhong Ping ^b   Xu, Zhi Yuan ^a   Christodoulopoulos, Garyfallia ^a   Bello, Vanessa ^a   Mohr, Gérard ^a   Aloyz, Raquel ^a   Panasci, Lawrence C ^a  

^a MCGILL UNIVERSITY   (Canada)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORMETHINE DERIVATIVE; DNA; DNA DEPENDENT PROTEIN KINASE; KU ANTIGEN; MELPHALAN; NUCLEIC ACID BINDING PROTEIN; RAD51 PROTEIN; RAD52 PROTEIN; SULFORHODAMINE B; UNCLASSIFIED DRUG; X RAY REPAIR CROSS COMPLEMENTING PROTEIN 2; X RAY REPAIR CROSS COMPLEMENTING PROTEIN 3;

ANTINEOPLASTIC ACTIVITY; ARTICLE; ASSAY; CANCER CELL CULTURE; CELL LINE; CONTROLLED STUDY; CORRELATION FUNCTION; CYTOTOXICITY; DNA CROSS LINKING; DNA REPAIR; DNA STRAND; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME ACTIVITY; EPITHELIUM TUMOR; GENE MUTATION; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; REGRESSION ANALYSIS; STATISTICAL ANALYSIS;

EID: 0035802230     PISSN: 00278874     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnci/93.19.1473     Document Type: Article

References (22)

1. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages
2. The contribution of homologous recombination in preserving genomic integrity in mammalian cells
3. Evidence that mammalian cells possess homologous recombinational repair pathways
4. The nuclear serine/threonine protein kinase DNA-PK
5. DNA-PK: At the cross-roads of biochemistry and genetics
6. Antitumor alkylating agents
7. DNA cross-linking as an indicator of sensitivity and resistance of L1210 leukemia cells to cis-diaminedichloroplatinum(II) and L-phenylalanine mustard
8. Mechanism of melphalan resistance developed in vitro in human melanoma cells
9. Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bi-functional alkylating agents
10. Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents
11. The scid mutation in mice causes defects in the repair system for both double-strand DNA breaks and DNA cross-links
12. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination
13. Xrcc3 is required for assembly of Rad51 complexes in vivo
14. Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes
15. S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes
16. Correlation of resistance to nitrogen mustards in chronic lymphocytic leukemia with enhanced removal of melphalan-induced DNA cross-links
17. DNA-dependent protein kinase activity correlates with clinical and in vitro sensitivity of chronic lymphocytic leukemia lymphocytes to nitrogen mustards
18. Chlorambucil induction of HsRad51 in B-cell chronic lymphocytic leukemia
19. Nitrogen mustard drug resistant B-cell chronic lymphocytic leukemia as an in vivo model for crosslinking agent resistance
20. DNA repair enzyme expression in chronic lymphocytic leukemia vis-a-vis nitrogen mustard drug resistance
21. 6-methylguanine-DNA methyl-transferase-mediated innate chloroethylnitrosourea resistance in human tumor cell lines
22. DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair