Evidence that mammalian cells possess homologous recombinational repair pathways

Mutation Research - DNA Repair

Volumn 363, Issue 2, 1996, Pages 77-88

  Thompson, Larry H ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

DNA cross links; Double strand break; Homologous recombination; Ionizing radiation; Mitomycin C; Mutagen sensitivity; Recombinational repair; XRCC genes

Indexed keywords

MITOMYCIN C;

ANIMAL CELL; DNA RECOMBINATION; DNA REPAIR; EVOLUTION; MAMMAL; NONHUMAN; PRIORITY JOURNAL; REVIEW; YEAST;

ANIMALIA; MAMMALIA;

EID: 0030580940     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/0921-8777(96)00008-0     Document Type: Short Survey

References (119)

1. Aboussekhra, A., M. Biggerstaff, M.K.K. Shivji, J.A. Vilpo, V. Moncollin, V.N. Podust, M. Protic, U. Hubscher, J.-M. Egly and R.D. Wood (1995) Mammalian DNA nucleotide excision repair reconstituted with purified protein components, Cell, 80, 859-868.
2. Aboussekhra, A. and R.D. Wood (1994) Repair of UV-damaged DNA by mammalian cells and Saccharomyces cerevisiae, Curr. Opin. Genet. Dev., 4, 212-220.
3. Bailis, A.M., L. Arthur and R. Rothstein (1992) Genome rearrangement in top3 mutants of Saccharomyces cerevisiae requires a functional RAD1 excision repair gene, Mol. Cell Biol., 12, 4988-4993.
4. Bardwell, A.J., L. Bardwell, A.E. Tomkinson and E.C. Friedberg (1994) Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 endonuclease, Science, 265, 2082-2085.
5. Basile, G., M. Aker and R.K. Mortimer (1992) Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51, Mol. Cell. Biol., 12, 3235-3246.
6. Bendixen, C., I. Sunjevaric, R. Bauchwitz and R. Rothstein (1994) Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52, Genomics, 23, 300-303.
7. Benson, F.E., A. Stasiak and S.C. West (1994) Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA, EMBO J., 13, 5764-5771.
8. Bezzubova, O.Y., H. Schmidt, K. Ostermann, W.D. Heyer and J.M. Buerstedde (1993) Identification of a chicken RAD52 homologue suggests conservation of the RAD52 recombination pathway throughout the evolution of higher eukaryotes, Nucleic Acids Res., 21, 5945-5949.
9. Birkenbihl, R.P. and S. Subramani (1992) Cloning and characterization of rad21 an essential gene of Schizosaccharomyces pombe involved in DNA double-strand-break repair, Nucleic Acids Res., 20, 6605-6611.
10. Birkenbihl, R.P. and S. Subramani (1995) The rad21 gene product of Schizosaccharomyces pombe is a nuclear, cell cycle-regulated phosphoprotein, J. Biol. Chem., 270, 7703-7711.
11. Blunt, T., N.J. Finnie, G.E. Taccioli, G.C. Smith, J. Demengeot, T.M. Gottlieb, R. Mizuta, A.J. Varghese, F.W. Alt, P.A. Jeggo and S.P. Jackson (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation, Cell, 80, 813-823.
12. +-dependent pathway for repair of DNA crosslinks, Mutation Res., 82, 229-238.
13. Brookman, K.W., J.E. Lamerdin, A. V. Carrano, M. Thelen, M. Hwang, A. Sancar and L.H. Thompson (1996) Excision repair gene ERCC4 is altered in xeroderma pigmentosum group F and homologous to the Drosophila mei-9 recombination/repair gene, Environ. Mol. Mutagen., 27, Suppl. 27, 10.
14. Buerstedde, J.M. and O. Bezzubova (1995) The RAD52 pathway is conserved during eukaryotic evolution, in: U. Hagen, H. Jung and C. Streffer (Eds.), Radiation Research 1895-1995, Congress Proceedings, Vol. 1, Eds., Universitätsdruckerei H. Stürtz AG, Würzburg, Germany, p. 48.
15. Busch, D.B., M.Z. Zdzienicka, A.T. Natarajan, N.J. Jones, W.I.J. Overkamp, A. Collins, D.L. Mitchell, M. Stefanini, E. Botta, R. Riboni, R.B. Albert, N. Liu and L.H. Thompson (1996) A FACEB CHO mutant, UV40, that is sensitive to diverse mutagens and represents a new complementation group of mitomycin C sensitivity, Mutation Res., in press.
16. Cassier, C., R. Chanet and E. Moustacchi (1984) Mutagenic and recombinogenic effects of DNA cross-links induced in yeast by 8-methoxypsoralen photoaddition, Photochem. Photobiol., 39, 799-803.
17. Cleaver, J.E. (1990) Do we know the cause of xeroderma pigmentosum?, Carcinogenesis, 11, 875-882.
18. Cole, R.S. (1973) Repair of DNA containing interstrand cross-links in Escherichia coli: Sequential excision and recombination, Proc. Natl. Acad. Sci. USA, 70, 1064-1068.
19. Collins, A.R. (1993) Mutant rodent cell lines sensitive to ultraviolet light, ionizing radiation and cross-linking agents: a comprehensive survey of genetic and biochemical characteristics, Mutation Res., 293, 99-118.
20. Davies, A.A., E.C. Friedberg, A.E. Tomkinson, R.D. Wood and S.C. West (1995) Role of the Rad1 and Rad10 proteins in nucleotide excision repair and recombination, J. Biol. Chem., 270, 24638-24641.
21. Eisen, J.A., K.S. Sweder and P.C. Hanawalt (1995) Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions, Nucleic Acids Res., 23, 2715-2723.
22. Fishman-Lobell, J. and J.E. Haber (1992) Removal of nonhomologous DNA ends in double-strand break recombination: the role of the yeast ultraviolet repair gene RAD1, Science, 258, 480-484.
23. Fishman-Lobell, J., N. Rudin and J.E. Haber (1992) Two alternative pathways of double-strand break repair that are kinetically separable and independently modulated, Mol. Cell. Biol., 12, 1292-1303.
24. Friedberg, E.C., G.C. Walker and W. Siede (1995) DNA Repair and Mutagenesis, American Soc. Microbiol., Washington, DC.
25. Fuller, L.F. and R.B. Painter (1988) A Chinese hamster ovary cell line hypersensitive to ionizing radiation and deficient in repair replication, Mutation Res., 193, 109-121.
26. Game, J.C. (1993) DNA double-strand breaks and the RAD50-RAD57 genes in Saccharomyces, Semin. Cancer Biol., 4, 73-83.
27. German, J. (1990) The chromosome-breakage syndromes: rare disorders that provide models for studying somatic mutation, in: L. Spatz, A.D. Bloom and N.W. Paul (Eds.), Detection of Cancer Predisposition: Laboratory Approaches, March of Dimes Birth Defects Foundation, White Plains, New York, pp. 85-111.
28. Getts, R.C. and T.D. Stamato (1994) Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant, J. Biol. Chem., 269, 15981-15984.
29. Haaf, T., E.I. Golub, G. Reddy, C.M. Radding and D.C. Ward (1995) Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes, Proc. Natl. Acad. Sci. USA, 92, 2298-2302.
30. Habraken, Y., P. Sung, L. Prakash and S. Prakash (1994) Holliday junction cleavage by yeast Rad1 protein, Nature, 371, 531-534.
31. Hang, B., A.T. Yeung and M.W. Lambert (1993) A damage-recognition protein which binds to DNA containing interstrand cross-links is absent or defective in Fanconi anemia, complementation group A, cells, Nucleic Acids Res., 21, 4187-4192.
32. Henriques, J.A. P., R. Chanet, D. Averbeck and E. Moustacchi (1977) Lethality and "petite" mutation induced by the photoaddition of 8-methoxypsoralen in yeast, Mol. Gen. Genet., 158, 63-72.
33. Hoeijmakers, J.H.J. (1994) Human nucleotide excision repair syndromes: molecular clues to unexpected intricacies, Eur. J. Cancer, 30A, 1912-1921.
34. Hoy, C.A., L.H. Thompson, C.L. Mooney and E.P. Salazar (1985) Defective DNA cross-link removal in Chinese hamster cell mutants hypersensitive to bifunctional alkylating agents, Cancer Res., 45, 1737-1743.
35. Ishida, R. and M. Buchwald (1982) Susceptibility of Fanconi's anemia lymphoblasts to DNA-cross-linking and alkylating agents, Cancer Res., 42, 4000-4006.
36. Ivanov, E.L. and J.E. Haber (1995) RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae, Mol. Cell Biol., 15, 2245-2251.
37. Jachymczyk, W.J., R.C. von Borstel, M.R. Mowat and P.J. Hastings (1981) Repair of interstrand cross-links in DNA of Saccharomyces cerevisiae requires two systems for DNA repair: the RAD3 system and the RAD51 system, Mol. Gen Genet., 182, 196-205.
38. Jackson, S.P. and P.A. Jeggo (1995) DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK, TIBS, 20, 412-415.
39. Jeggo, P.A. (1990) Studies on mammalian mutants defective in rejoining double-strand breaks in DNA, Mutation Res., 239, 1-16.
40. Jeggo, P.A. and L.M. Kemp (1983) X-ray-sensitive mutants of Chinese hamster ovary cell line: Isolation and cross-sensitivity to other DNA-damaging agents, Mutation Res., 112, 313-327.
41. Jeggo, P.A. G.E. Taccioli and S.P. Jackson (1995) Menage à trois: double-strand break repair, V(D)J recombination and DNA-PK, BioEssays, 17, 949-957.
42. Jessberger, R. and P. Berg (1991) Repair of deletions and double-strand gaps by homologous recombination in a mammalian in vitro system, Mol. Cell Biol., 11, 445-457.
43. Jessberger, R., V. Podust, U. Hübscher and P. Berg (1993) A mammalian protein complex that repairs double-strand breaks and deletions by recombination, J. Biol. Chem., 268, 15070-15079.
44. Jessberger, R., B. Riwar, A. Rolink and H.R. Rodewald (1995) Stimulation of defective DNA transfer activity in recombination deficient SCID cell extracts by a 72-kDa protein from wild-type thymocytes, J. Biol. Chem, 270, 6788-6797.
45. Jones, N.J. (1994) Genetic analysis of mitomycin C-hypersensitive Chinese hamster cell mutants, Mutagenesis, 9, 477-482.
46. Jones, N.J., R. Cox and J. Thacker (1987) Isolation and cross-sensitivity of X-ray-sensitive mutants of V79-4 hamster cells, Mutation Res., 183, 279-286.
47. Jones, N.J., S.A. Stewart and L.H. Thompson (1990) Biochemical and genetic analysis of the Chinese hamster mutants irs1 and irs2 and their comparison to cultured ataxia telangiectasia cells, Mutagenesis, 5, 15-23.
48. Jones, N.J., Y. Zhao, M.J. Siciliano and L.H. Thompson (1995) Assignment of the XRCC2 human DNA repair gene to chromosome 7q36 by complementation analysis, Genomics, 26, 619-622.
49. Kemp, L.M., S.G. Sedgwick and P. Jeggo (1984) X-ray sensitive mutants of CHO cells defective in double-strand break rejoining, Mutation Res., 132, 189-196.
50. Kirchgessner, C.U., C.K. Patil, J.W. Evans, C.A. Cuomo, L.M. Fried, T. Carter, M.A. Oettinger and J.M. Brown (1995) DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect, Science, 267, 1178-1183.
51. Klein, H.L. (1988) Different types of recombination events are controlled by the RAD1 and RAD52 genes of Saccharomyces cerevisiae, Genetics, 120, 367-377.
52. Kumaresan, K.R., B. Hang and M.W. Lambert (1995) Human endonucleolytic incision of DNA 3′ and 5′ to a site-directed psoralen monoadduct and interstrand cross-link, J. Biol. Chem., 270, 30709-30716.
53. Kumaresan, K.R., M. Ramaswamy and A.T. Yeung (1992) Structure of the DNA interstrand cross-link of 4,5′,8-trimethyl-psoralen, Biochemistry, 31, 6774-6783.
54. Lees-Miller, S.P., R. Godbout, D.W. Chan, M. Weinfeld, R.S. 3rd Day, G. M. Barron and J. Allalunis-Turner (1995) Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line, Science, 267, 1183-1185.
55. Liu, N., J.E. Lamerdin, M.J. Siciliano, A. V. Carrano and L.H. Thompson (1995) Molecular cloning of the XRCC2 human DNA repair gene, which is similar to RAD51 of S. cerevisiae, Am. J. Hum. Genet., Suppl. 57, A147.
56. Magana-Schwencke, N., J.A. Henriques, R. Chanet and E. Moustacchi (1982) The fate of 8-methoxypsoralen photoinduced crosslinks in nuclear and mitochondrial yeast DNA: comparison of wild-type and repair-deficient strains, Proc. Natl. Acad. Sci. USA, 79, 1722-1726.
57. McKay, M., C. Troelstra, B. Smit, Hagemeijer A. and J.H.J. Hoeijmakers (1995) Cloning of human, mouse and C. elegans homologs of the fission yeast DNA DSB repair gene, in: U. Hagen, H. Jung and C. Streffer (Eds.), Radiation Research 1895-1995, Congress Proceedings, Vol. 1, Universitätsdruckerei H. Stürtz AG, Würzburg, Germany, p. 297.
58. Meyn, R.E., S.F. Jenkins and L.H. Thompson (1982) Defective removal of DNA cross-links in a repair-deficient mutant of Chinese hamster cells, Cancer Res., 42, 3106-3110.
59. Mimori, T., J.A. Hardin and J.A. Steitz (1986) Characterization of the DNA-binding protein antigen Ku recognized by autoanti-bodies from patients with rheumatic disorders, J. Biol. Chem., 261, 2274-2278.
60. Moore, P.D. and R. Holliday (1976) Evidence for the formation of hybrid DNA during mitotic recombination in Chinese hamster cells, Cell, 8, 573-579.
61. Morita, T., Y. Yoshimura, A. Yamamoto, K. Murata, M. Mori, H. Yamamoto and A. Matsushiro (1993) A mouse homolog of the Escherichia coli recA and Saccharomyces cerevisiae RAD51 genes, Proc. Natl. Acad. Sci. USA, 90, 6577-6580.
62. Mu, D., D.S. Hsu and A. Sancar (1996) Reaction mechanism of human DNA repair excision nuclease, J. Biol. Chem., 271, 8285-8294.
63. Muris D.F., K. Vreeken, A.M. Carr, B.C. Broughton, A.R. Lehmann, P.H. Lohman and A. Pastink (1993) Cloning the RAD51 homologue of Schizosaccharomyces pombe, Nucleic Acids Res., 21, 4586-4591.
64. Murray, D., A. Prager, R.E. Meyn, S. Davison and A.D. Green (1993) Relationships between DNA damage and the survival of radiosensitive mutant Chinese hamster cell lines exposed to γ-radiation: Part 2. Effect of cellular redox status, Int. J. Radiat. Biol., 63, 199-206.
65. Orr-Weaver, T.L. and J.W. Szostak (1983) Yeast recombination: the association between double-strand gap repair and crossing-over, Proc. Natl. Acad. Sci. USA, 80, 4417-4421.
66. Ostermann, K., A. Lorentz and H. Schmidt (1993) The fission yeast rad22 gene, having a function in mating-type switching and repair of DNA damages, encodes a protein homolog to Rad52 of Saccharomyces cerevisiae, Nucleic Acids Res., 21, 5940-5944.
67. Overkamp, W.J.I., M.A. Rooimans, I. Neuteboom, P. Telleman, F. Arwert and M.Z. Zdzienicka (1993) Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: a new complementation group with chromosomal instability, Somat. Cell Mol. Genet., 19, 431-437.
68. Painter, R.B. (1980) A replication model for sister-chromatid exchange, Mutation Res., 70, 337-341.
69. Park, C.H., T. Matsunaga, T. Bessho and A. Sancar (1995) Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease, J. Biol. Chem., 270, 22657-22660.
70. Park, M.S. (1995) Expression of human RAD52 confers resistance to ionizing radiation in mammalian cells, J. Biol. Chem., 270, 15467-15470.
71. Parrish, D.D., W.C. Lambert and M.W. Lambert (1992) Xeroderma pigmentosum endonuclease complexes show reduced activity on and affinity for psoralen cross-linked nucleosomal DNA, Mutation Res., 273, 157-170.
72. Perry, P. and S. Wolff (1974) New giemsa method for the differential staining of sister chromatids, Nature, 251, 156-158.
73. Peterson, S.R., A. Kurimasa, M. Oshimura, W.S. Dynan, E.M. Bradbury and D.J. Chen (1995) Loss of the catylatic subunit of the DNA-dependent protein kinase in DNA double-strand break repair mutant mammalian cells, Proc. Natl. Acad. Sci. USA, 92, 3171-3174.
74. Price, A. (1993) The repair of ionising radiation-induced damage to DNA, Semin. Cancer Biol., 4, 61-71.
75. Rathmell, W.K. and G. Chu (1994a) A DNA end-binding factor involved in double-strand break repair and V(D)J recombination, Mol. Cell. Biol., 14, 4741-4748.
76. Rathmell, W.K. and G. Chu (1994b) Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks, Proc. Natl. Acad. Sci. USA, 91, 7623-7627.
77. Resnick, M., C. Bennett, N. Kouprina, V. Larionov, K. Lewis and H. Tran (1996) Recombinational repair of double-strand breaks: twenty years later, in: U. Hagen, H. Jung and C. Streffer (Eds.), Radiation Research 1895-1995, Congress Proceedings, Vol. 2, Universitätsdruckerei H. Stürtz AG, Würzburg, Germany, in press.
78. Rubin, J.S. and G.F. Whitmore (1985) DNA repair-deficient Chinese hamster ovary cells exhibiting differential sensitivity to gamma rays under aerobic and hypoxic conditions, Radiat. Res., 101, 528-534.
79. Saffran, W.A., R.B. Greenberg, M.S. Thaler-Scheer and M.M. Jones (1994) Single strand and double strand DNA damage-induced reciprocal recombination in yeast. Dependence on nucleotide excision repair and RAD1 recombination, Nucleic Acids Res., 22, 2823-2829.
80. Sancar, A. (1996) DNA excision repair, Annu. Rev. Biochem., 65, 43-81.
81. Sargentini, N.J. and K.C. Smith (1986) Quantitation of the involvement of the recA, recB, recC, recF, recJ, recN, lexA, radA, radB, uvrD, and umuC genes in the repair of X-ray-induced DNA double-strand breaks in Escherichia coli, Radiat. Res., 107, 58-72.
82. Schiestl, R.H. and S. Prakash (1988) RAD1, an excision repair gene of Saccharomyces cerevisiae, is also involved in recombination, Mol. Cell. Biol., 8, 3619-3626.
83. Schiestl, R.H. and S. Prakash (1990) RAD10, an excision repair gene of Saccharomyces cerevisiae, is involved in the RAD1 pathway of mitotic recombination, Mol. Cell. Biol., 10, 2485-2491.
84. Shen, Z., K. Denison, R. Lobb, J.M. Gatewood and DJ. Chen (1995) The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13 and mRNA expression in mouse tissues, Genomics, 25, 199-206.
85. Shen, Z., G. Cloud, D.J. Chen and M.S. Park (1996) Specific interactions between the human RAD51 and RAD52 proteins, J. Biol. Chem., 271, 148-152.
86. Shinohara, A., H. Ogawa, Y. Matsuda, N. Ushio, K. Ikeo and T. Ogawa (1993) Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA, Nat. Genet., 4, 239-243.
87. Siede, W., A.A. Friedl, I. Dianova, F. Eckardt-Schupp and E.C. Friedberg (1996) The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination, Genetics, 142, 91-102.
88. Sinden, R.R. and R.S. Cole (1978) Repair of cross-linked DNA and survival of Escherichia coli treated with psoralen and light: effects of mutations influencing genetic recombination and DNA metabolism, J. Bacteriol., 136, 538-547.
89. Sorenson, C.M. and E. Eastman (1988) Influence of cis-diamminedichloroplatinum(II) on DNA synthesis and cell cycle progession in excision repair proficient and deficient Chinese hamster ovary cells, Cancer Res., 48, 6703-6707.
90. Stamato, T.D., A. Dipatri and A. Giaccia (1988) Cell cycle-dependent repair of potentially lethal damage in the XR-1 γ-ray sensitive CHO cell, Radiat. Res., 115, 325-333.
91. Studzian, K., P. Telleman, G.P. van der Schans and M.Z. Zdzienicka (1994) Mutagenic response and repair of cis-DDP-induced DNA cross-links in the Chinese hamster V79 cell mutant V-H4 which is homologous to Fanconi anemia (group A), Mutation Res., 314, 115-120.
92. Sung, P. (1994) Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein, Science, 265, 1241-1243.
93. Sung, P., P. Reynolds, L. Prakash and S. Prakash (1993) Purification and characterization of the Saccharomyces cerevisiae RAD1/RAD10 endonuclease, J. Biol. Chem., 268, 26391-26399.
94. Suwa, A., M. Hirakata, Y. Takeda, S. A. Jesch, T. Mimori and J.A. Hardin (1994) DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA, Proc. Natl. Acad. Sci. USA, 91, 6904-6908.
95. Taccioli, G.E., T.M. Gottlieb, T. Blunt, A. Priestley, J. Demengeot, R. Mizuta, A.R. Lehmann, F.W. Alt, S.P. Jackson and P.A. Jeggo (1994) Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination, Science, 265, 1442-1445.
96. Takahashi, E., Y. Matsuda, T. Hori, N. Yasuda, S. Tsuji, M. Mori, Y. Yoshimura, A. Yamamoto, T. Morita and A. Matsushiro (1994) Chromosome mapping of the human (RECA) and mouse (Reca) homologs of the yeast RAD51 and Escherichia coli recA genes to human (15q15.1) and mouse (2F1) chromosomes by direct R-banding fluorescence in situ hybridization, Genomics, 19, 376-378.
97. Tebbs, R.S., Y. Zhao, J.D. Tucker, J.B. Scheerer, M.J. Siciliano, M. Hwang, N. Liu, R.J. Legerski and L.H. Thompson (1995) Correction of chromosomal instability and sensitivity to diverse mutagens by a cDNA of the XRCC3 DNA repair gene, Proc. Natl. Acad. Sci. USA, 92, 6354-6358.
98. Telleman, P., W.J. Overkamp, N. van Wessel, K. Studzian, L. Wetselaar, A.T. Natarajan and M.Z. Zdzienicka (1995) A new complementation group of mitomycin C-hypersensitive Chinese hamster cell mutants that closely resembles the phenotype of fanconi anemia cells, Cancer Res., 55, 3412-3416.
99. Thacker, J. and A.N. Ganesh (1990) DNA-break repair, radioresistance of DNA synthesis and camptothecin sensitivity in the radiation-sensitive irs mutants: Comparisons to ataxia-telangiectasia cells, Mutation Res., 235, 49-58.
100. Thacker, J., C.E. Tambini, P.J. Simpson, L.-C Tsui and S.W. Scherer (1995) Localization to chromosome 7q36.1 of the human XRCC2 gene, determining sensitivity to DNA-damaging agents, Human Mol. Genet., 4, 113-120.
101. Thomas, B.J. and R. Rothstein (1989) The genetic control of direct-repeat recombination in Saccharomyces: the effect of rad52 and rad1 on mitotic recombination at GAL10, a transcriptionally regulated gene, Genetics, 123, 725-738.
102. Thompson, L.H. (1996) Nucleotide excision repair: Its relation to human disease, in: J.A. Nickoloff and M. Hoekstra (Eds.), DNA Damage and Repair-Biochemistry, Genetics and Cell Biology, Humana Press, submitted.
103. Thompson, L. and D. Bootsma (1988) Designation of mammalian complementation groups and repair genes, in: E.C. Friedberg and P.C. Hanawalt (Eds.), Mechanisms and Consequences of DNA Damage Processing, Alan R. Liss, New York, p. 279.
104. Thompson, L.H., K.W. Brookman, L.E. Dillehay, A.V. Carrano, J.A. Mazrimas, C.L. Mooney and J.L. Minkler (1982a) A CHO-cell strain having hypersensitivity to mutagens, a defect in strand-break repair and an extraordinary baseline frequency of sister chromatid exchange, Mutation Res., 95, 427-440.
105. Thompson, L.H., K.W. Brookman, L.E. Dillehay, C.L. Mooney and A.V. Carrano (1982b) Hypersensitivity to mutation and sister-chromatid-exchange induction in CHO cell mutants defective in incising DNA containing UV lesions, Somat. Cell. Genet., 8, 759-773.
106. Thompson, L.H., S. Fong and K. Brookman (1980a) Validation of conditions for efficient detection of HPRT and APRT mutations in suspension-cultured Chinese hamster cells, Mutation Res., 74, 21-36.
107. Thompson, L.H. and P.A. Jeggo (1995) Nomenclature of human genes involved in ionizing radiation sensitivity, Mutation Res., 337, 131-134.
108. Thompson, L.H., J.S. Rubin, J.E. Cleaver, G.F. Whitmore and K. Brookman (1980b) A screening method for isolating DNA repair-deficient mutants of CHO cells, Somat. Cell. Genet., 6, 391-405.
109. Tomkinson, A.E., A.J. Bardwell, L. Bardwell, N.J. Tappe and E.C. Friedberg (1993) Yeast DNA repair and recombination proteins Rad1 and Rad10 constitute a single-stranded-DNA endonuclease, Nature, 362, 860-862.
110. Troelstra, C., R. Kanaar, S. Swagemakers, J. Essers, J.H. Franssen, D. Bootsma, J.H.J. Hoeijmakers, P.C. Levendag, J.M. Buerstedde, D. Muris and A. Pastink Molecular analysis of genes involved in recombination repair, in: U. Hagen, H. Jung and C. Streffer (Eds.), Radiation Research 1895-1995, Congress Proceedings, Vol. 1, Universitätsdruckerei H. Stürtz AG, Würzburg, Germany, p. 82.
111. Vos, J.M. (1992) Cis and trans mechanisms of DNA repair, Curr Opin Cell Biol., 4, 385-395.
112. Ward, J.F. (1988) DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation and reparability, Prog. Nucleic Acid Res. Mol. Biol., 35, 95-125.
113. Weaver, D.T. (1995) What to do at an end: DNA double-strand-break repair, Trends Genet., 11, 388-392.
114. West, S.C. (1995) Holliday junctions cleaved by Rad1? [letter], Nature, 373, 27-28.
115. Whitmore, G.F., A.J. Varghese and S. Gulyas (1989) Cell cycle responses of two X-ray sensitive mutants defective in DNA repair, Int. J. Radiat. Biol., 56, 657-665.
116. 6-methylguanine-DNA methyltransferase in a DNA excision repair-deficient Chinese hamster ovary cell line and its response to certain alkylating agents, Cancer Res., 52, 32-35.
117. Yoshimura, Y., T. Morita, A. Yamamoto and A. Matsushiro (1993) Cloning and sequence of the human RecA-like gene cDNA, Nucleic Acids Res., 21, 1665.
118. Zdzienicka, M.Z. (1995) Mammalian mutants defective in the response to ionizing radiation-induced DNA damage, Mutation Res., 336, 203-213.
119. Zehfus, B.R., A.D. McWilliams, Y.H. Lin, M.F. Hoekstra and R.L. Keil (1990) Genetic control of RNA polymerase I-stimulated recombination in yeast, Genetics, 126, 41-52.