Activation of the Ras-cAMP Signal Transduction Pathway Inhibits the Proteasome-independent Degradation of Misfolded Protein Aggregates in the Endoplasmic Reticulum Lumen

Journal of Biological Chemistry

Volumn 276, Issue 44, 2001, Pages 41444-41454

  Umebayashi, Kyohei ^a,b   Fukuda, Ryouichi ^a   Hirata, Aiko ^a   Horiuchi, Hiroyuki ^a   Nakano, Akihiko ^b   Ohta, Akinori ^a   Takagi, Masamichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEGRADATION; YEAST;

SIGNAL TRANSDUCTION;

PROTEINS;

ASPARTIC PROTEINASE; CYCLIC AMP; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; MUTANT PROTEIN; PROTEASOME; PROTEIN IRA2; RAS PROTEIN; SECRETORY PROTEIN; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE I; ASPARTIC PROTEINASE-I; CYSTEINE PROTEINASE; MULTIENZYME COMPLEX;

ARTICLE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENDOPLASMIC RETICULUM; GENE DELETION; GENE MUTATION; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RHIZOPUS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; ELECTRON MICROSCOPY; ESCHERICHIA COLI; GENETICS; HYDROLYSIS; METABOLISM; PROTEIN TRANSPORT; ULTRASTRUCTURE;

RHIZOPUS; RHIZOPUS NIVEUS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

ASPARTIC ENDOPEPTIDASES; CYCLIC AMP; CYSTEINE ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI; HYDROLYSIS; MICROSCOPY, ELECTRON; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN TRANSPORT; RAS PROTEINS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 0035798594     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105829200     Document Type: Article

References (85)

1. Klausner, R. D., and Sitia, R. (1990) Cell 62, 611-614
2. Bonifacino, J. S., and Lippincott-Schwartz, J. (1991) Curr. Opin. Cell Biol. 3, 592-600
3. Tsao, Y. S., Ivessa, N. E., Adesnik, M., Sabatini, D. D., and Kreibich G. (1992) J. Cell Biol. 116, 57-67
4. Roitelman, J., Bar-Nun, S., Inoue, S., and Simoni, R. D. (1991) J. Biol. Chem. 266, 16085-16091
5. Wileman, T., Kane, L. P., Carson, G. R., and Terhorst, C. (1991) J. Biol. Chem. 266, 4500-4507
6. Hwang, C., Sinskey, A. J., and Lodish, H. F. (1992) Science 257, 1496-1502
7. Stafford, F. J., and Bonifacino, J. S. (1991) J. Cell Biol. 115, 1225-1236
8. Young, J., Kane, L. P., Exley, M., and Wileman, T. (1993) J. Biol. Chem. 268, 19810-19818
9. Inoue, S., and Simoni, R. D. (1992) J. Biol. Chem. 267, 9080-9086
10. Gardner, A. M., Aviel, S., and Argon, Y. (1993) J. Biol. Chem. 268, 25940-25947
11. Ward, C. L., Omura, S., and Kopito, R. R. (1995) Cell 83, 121-127
12. Jensen, T. J., Loo, M. A., Pind, S., Williams, D. B., Goldberg, A. L., Riordan, J. R. (1995) Cell 83, 129-135
13. Wiertz, E. J. H. J., Jones, T. R., Sun, L., Bogyo, M., Geuze, H. J., and Ploegh, H. L. (1996) Cell 84, 769-779
14. Wiertz, E. J. H. J., Tortorella, D., Bogyo, M., Yu, J., Mothes, W., Jones, T. R., Rapoport, T. A., and Ploegh, H. L. (1996) Nature 384, 432-438
15. Biederer, T., Volkwein, C., and Sommer, T. (1996) EMBO J. 15, 2069-2076
16. Hampton, R. Y., Gardner, R. G., and Rine, J. (1996) Mol. Biol. Cell 7, 2029-2044
17. McCracken, A. A., and Brodsky, J. L. (1996) J. Cell Biol. 132, 291-298
18. Werner, E. D., Brodsky, J. L., and McCracken, A. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 13797-13801
19. Hiller, M. M., Finger, A., Schweiger, M., and Wolf, D. H. (1996) Science 273, 1725-1728
20. Brodsky, J. L., and McCracken, A. A. (1997) Trends Cell Biol. 7, 151-156
21. Bonifacino, J. S., and Weissman, A. M. (1998) Annu. Rev. Cell Dev. Biol. 14, 19-57
22. Pilon, M., Schekman, R., and Römisch, K. (1997) EMBO J. 16, 4540-4548
23. Plemper, R. K., Böhmler, S., Bordallo, J., Sommer, T., and Wolf, D. H. (1997) Nature 388, 891-895
24. Plemper, R. K., Egner, R., Kuchler, K., and Wolf, D. H. (1998) J. Biol. Chem. 273, 32848-32856
25. Zhou, M., and Schekman, R. (1999) Mol. Cell 4, 925-934
26. Knop, M., Finger, A., Braun, T., Hellmuth, K., and Wolf, D. H. (1996) EMBO J. 15, 753-763
27. Bordallo, J., Plemper, R. K., Finger, A., and Wolf, D. H. (1998) Mol. Biol. Cell 9, 209-222
28. Plemper, R. K., Bordallo, J., Deak, P. M., Taxis, C., Hitt, R., and Wolf, D. H. (1999) J. Cell Sci. 112, 4123-4134
29. Holkeri, H., and Makarow, M. (1998) FEBS Lett. 429, 162-166
30. Ozols, J. (1997) Mol. Biol. Cell 8, 2281-2290
31. Heinemann, F. S., and Ozols, J. (1998) Mol. Biol. Cell 9, 3445-3453
32. Moriyama, T., Sather, S. K., McGee, T. P., and Simoni, R. D. (1998) J. Biol. Chem. 273, 22037-22043
33. Mullins, C., Lu, Y. Q., Campbell, A., Fang, H., and Green, N. (1995) J. Biol. Chem. 270, 17139-17147
34. Fukuda, R., Umebayashi, K., Horiuchi, H., Ohta, A., and Takagi, M. (1996) J. Biol. Chem. 271, 14252-14255
35. Horiuchi, H., Yanai, K., Okazaki, T., Takagi, M., and Yano, K. (1988) J. Bacteriol. 170, 272-278
36. Fukuda, R., Horiuchi, H., Ohta, A., and Takagi, M. (1994) J. Biol. Chem. 269, 9556-9561
37. Umebayashi, K., Hirata, A., Fukuda, R., Horiuchi, H., Ohta, A., and Takagi, M. (1997) Yeast 13, 1009-1020
38. Umebayashi, K., Hirata, A., Horiuchi, H., Ohta, A., and Takagi, M. (1999) Eur. J. Cell Biol. 78, 726-738
39. Ito, H., Fukuda, Y., Murata, K., and Kimura, A. (1983) J. Bacteriol. 153, 163-168
40. Sherman, F. (1991) Methods Enzymol. 194, 3-21
41. Stotz, A., and Linder, P. (1990) Gene 95, 91-98
42. Sikorski, R. S., and Hieter, P. (1989) Genetics 122, 19-27
43. Tanaka, K., Nakafuku, M., Tamanoi, F., Kaziro, Y., Matsumoto, K., and Toh-e, A. (1990) Mol. Cell. Biol. 10, 4303-4313
44. Bachmair, A., Finley, D., and Varshavsky, A. (1986) Science 234, 179-186
45. Sun, G.-H., Hirata, A., Ohya, Y., and Anraku, Y. (1992) J. Cell Biol. 119, 1625-1639
46. Veenhuis, M., Douma, A., Harder, W., and Osumi, M. (1983) Arch. Microbiol. 134, 193-203
47. Tuttle, D. L., Lewin, A. S., and Dunn, W. A., Jr. (1993) Eur. J. Cell Biol. 60, 283-290
48. Takeshige, K., Baba, M., Tsuboi, S., Noda, T., and Ohsumi, Y. (1992) J. Cell Biol. 119, 301-311
49. Nakano, A., Brada, D., and Schekman, R. (1988) J. Cell Biol. 107, 851-863
50. Plemper, R. K., and Wolf, D. H. (1999) Trends Biochem. Sci. 24, 266-270
51. Coux, O., Tanaka, K., and Goldberg, A. L. (1996) Annu. Rev. Biochem. 65, 801-847
52. Lee, D. H., and Goldberg, A. L. (1996) J. Biol. Chem. 271, 27280-27284
53. Loayza, D., Tam, A., Schmidt, W. K., and Michaelis, S. (1998) Mol. Biol. Cell 9, 2767-2784
54. Suzuki, T., Park, H., Hollingsworth, N. M., Sternglanz, R., and Lennarz, W. J. (2000) J. Cell Biol. 149, 1039-1051
55. Heinemeyer, W., Kleinschmidt, J. A., Saidowsky, J., Escher, C., and Wolf, D. (1991) EMBO J. 10, 555-562
56. Cox, J. S., Shamu, C. E., and Walter, P. (1993) Cell 73, 1197-1206
57. Mori, K., Ma, W., Gething, M.-J., and Sambrook, J. (1993) Cell 74, 743-756
58. Kataoka, T., Powers, S., McGill, C., Fasano, O., Strathern, J., Broach, J., and Wigler, M. (1984) Cell 37, 437-445
59. Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J. D., McMullen, B., Hurwitz, M., Krebs, E. G., and Wigler, M. (1987) Mol. Cell. Biol. 7, 1371-1377
60. Matsuura, A., and Anraku, Y. (1993) Mol. Gen. Genet. 238, 6-16
61. Cannon, J. F., Pringle, J. R., Fiechter, A., and Khalil, M. (1994) Genetics 136, 485-503
62. Thevelein, J. M., and de Winde, J. H. (1999) Mol. Microbiol. 33, 904-918
63. Sass, P., Field, J., Nikawa, J., Toda, T., and Wigler, M. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 9303-9307
64. Tanaka, K., Matsumoto, K., and Toh-e, A. (1989) Mol. Cell. Biol. 9, 757-768
65. Tanaka, K., Nakafuku, M., Satoh, T., Marshall, M. S., Gibbs, J. B., Matsumoto, K., Kaziro, Y., and Toh-e, A. (1990) Cell 60, 803-807
66. Tanaka, K., Lin, B. K., Wood, D. R., and Tamanoi, F. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 468-472
67. Morishita, T., Mitsuzawa, H., Nakafuku, M., Nakamura, S., Hattori, S., and Anraku, Y. (1995) Science 270, 1213-1215
68. Bolender, R. P., and Weibel, E. R. (1973) J. Cell Biol. 56, 746-761
69. Hong, E., Davidson, A. R., and Kaiser, C. A. (1996) J. Cell Biol. 135, 623-633
70. Wright, R., Basson, M., D'Ari, L., and Rine, J. (1988) J. Cell Biol. 107, 101-114
71. Lum, P. Y., and Wright, R. (1995) J. Cell Biol. 131, 81-94
72. Friedlander, R., Jarosch, E., Urban, J., Volkwein, C., and Sommer, T. (2000) Nat. Cell Biol. 2, 379-384
73. Reynolds, T. B., Hopkins, B. D., Lyons, M. R., and Graham, T. R. (1998) J. Cell Biol. 143, 935-946
74. Huang, L. J.-s., Wang, L., Ma, Y., Durick, K., Perkins, G., Deerinck, T. J., Ellisman, M. H., and Taylor, S. S. (1999) J. Cell Biol. 145, 951-959
75. Robertson, L. S., and Fink, G. R. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 13783-13787
76. Pan, X., and Heitman, J. (1999) Mol. Cell. Biol. 19, 4874-4887
77. Hayes, S. A., and Dice, J. F. (1996) J. Cell Biol. 132, 255-258
78. Brodsky, J. L., Werner, E. D., Dubas, M. E., Goeckeler, J. L., Kruse, K. B., and McCracken, A. A. (1999) J. Biol. Chem. 274, 3453-3460
79. Casagrande, R., Stern, P., Diehn, M., Shamu, C., Osario, M., Zúñiga, M., Brown, P. O., and Ploegh, H. (2000) Mol. Cell 5, 729-735
80. Ng, D. T. W., Spear, E. D., and Walter, P. (2000) J. Cell Biol. 150, 77-88
81. Smith, A., Ward, M. P., and Garrett, S. (1998) EMBO J. 17, 3556-3564
82. Moskvina, E., Schüller, C., Maurer, C. T. C., Mager, W. H., and Ruis, H. (1998) Yeast 14, 1041-1050
83. Schüller, C., Brewster, J. L., Alexander, M. R., Gustin, M. C., and Ruis, H. (1994) EMBO J. 13, 4382-4389
84. Hänninen, A.-L., Simola, M., Saris, N., and Makarow, M. (1999) Mol. Biol. Cell 10, 3623-3632
85. Horiuchi, H., Ashikari, T., Amachi, T., Yoshizumi, H., Takagi, M., and Yano, K. (1990) Agric. Biol. Chem. 54, 1771-1779