The Dictyostelium Bcr/Abr-related protein DRG regulates both Rac- and Rab-dependent pathways

EMBO Journal

Volumn 20, Issue 7, 2001, Pages 1620-1629

  Knetsch, Menno L W ^a   Schäfers, Nicole ^a   Horstmann, Heinz ^b   Manstein, Dietmar J ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Actin; Contractile vacuole; Dictyostelium; RabD; Rac

Indexed keywords

CYCLIC AMP; F ACTIN; GUANOSINE TRIPHOSPHATASE; PROTEIN DDRACGAP1; RAB PROTEIN; RAC PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CYTOKINESIS; DICTYOSTELIUM DISCOIDEUM; HYDROLYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATOR GENE;

ANIMALS; DICTYOSTELIUM; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; PROTEIN-TYROSINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCR; RAB GTP-BINDING PROTEINS; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; MAMMALIA;

EID: 0035794708     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.7.1620     Document Type: Article

References (55)

1. Basic local alignment search tool
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. Effectors for the Rho GTPases
4. Proteins regulating Ras and its relatives
5. The GTPase superfamily: A conserved switch for diverse cell functions
6. Comparative analysis of chemotaxis in Dictyostelium using a radial bioassay method: Protein tyrosine kinase activity is required for chemotaxis to folate but not to cAMP
7. A flexible motif search technique based on generalized profiles
8. Cloning and characterization of seven novel Dictyostelium discoideum rac-related genes belonging to the rho family of GTPases
9. A role for a Rab4-like GTPase in endocytosis and in regulation of contractile vacuole structure and function in Dictyostelium discoideum
10. Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family
11. Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells
12. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
13. Induction of chronic myelogenous leukemia in mice by the P210Bcr/abl gene of the Philadelphia chromosome
14. Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein β subunits
15. Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium
16. The IQGap-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility
17. The contractile vacuole network of Dictyostelium as a distinct organelle: Its dynamics visualized by a GFP marker protein
18. A role for Dictyostelium race in cortical tension and cleavage furrow progression
19. Lfc and Lsc oncoproteins represent two new guanine nucleotide exchange factors for the Rho GTP-binding protein
20. Rho GTPases and the actin cytoskeleton
21. Relationship of pseudopod extension to chemotactic hormone-induced actin polymerization in amoeboid cells
22. Abr, an active Bcr-related gene
23. Acute leukaemia in Bcr/Abl transgenic mice
24. Human Abr encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain
25. The PROSITE database, its status in 1999
26. The Rho GTPases in macrophage motility and chemotaxis
27. Modular PH and C2 domains in membrane attachment and other functions
28. A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis
29. Role of Dictyostelium Race in cytokinesis - Mutational analysis and localization studies by use of green fluorescent protein
30. Cloning and characterization of a RhoGAP homolog from Dictyostelium discoideum
31. Cloning vectors for the production of proteins in Dictyostelium discoideum
32. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
33. A universal ethane-freezing/methanol-fixation procedure highly improves preservation of structure and antigenicity in immunofluorescence and pre-embedding immunoelectron microscopy
34. 1
35. Docked granules, the exocytic burst, and the need for ATP hydrolysis in endocrine cells
36. G protein β subunit-null mutants are impaired in phagocytosis and chemotaxis due to inappropriate regulation of the actin cytoskeleton
37. SMART: Identification and annotation of domains from signalling and extracellular protein sequences
38. Crystal structure of the GAP domain of Gyp1p: First insights into interaction with Ypt/Rab proteins
39. Pleckstrin homology domains: A common fold with diverse functions
40. Signalling by Rho family proteins
41. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
42. RacF1, a novel member of the Rho protein family in Dictyostelium discoideum, associates transiently with cell contact areas, macropinosomes, and phagosomes
43. Synaptic-like microvesicles of neuroendocrine cells originate from a novel compartment that is continuous with the plasma membrane and devoid of transferrin receptor
44. smart, a simple modular architecture research tool - Identification of signaling domains
45. Overexpression of a novel rho family GTPase, RacC, induces unusual actin-based structures and positively affects phagocytosis in Dictyostelium discoideum
46. Crystal structure of the Dbl and pleckstrin homology domains from the human son of sevenless protein
47. Transport, docking and exocytosis of single secretory granules in live chromaffin cells
48. The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins
49. Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
50. Rho family members: Activators of MAP kinase cascades
51. Increased neutrophil respiratory burst in Bcr-null mutants
52. Bcr/Abl associated leukemogenesis in Bcr null mutant mice
53. Growth of myxamoebae of the cellular slime mold Dictyostelium discoideum in axenic culture
54. Disruption of a dynamin homologue affects endocytosis, organelle morphology, and cytokinesis in Dictyostelium discoideum
55. The interaction of Ras with GTPase-activating proteins